PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease von Kazlauskaite, Agne, Muqit, Miratul M. K

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Expanding insights of mitochondrial dysfunction in Parkinson's disease von Wood, Nicholas W, Abou-Sleiman, Patrick M, Muqit, Miratul M. K

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 von Valente, Enza Maria, Abou-Sleiman, Patrick M., Caputo, Viviana, Miratul M. K. Muqit, Harvey, Kirsten, Gispert, Suzana, Ali, Zeeshan, Del Turco, Domenico, Bentivoglio, Anna Rita, Healy, Daniel G., Albanese, Alberto, Nussbaum, Robert, González-Maldonado, Rafael, Deller, Thomas, Salvi, Sergio, Cortelli, Pietro, Gilks, William P., Latchman, David S., Harvey, Robert J., Dallapiccola, Bruno, Auburger, Georg, Wood, Nicholas W.

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 von Kondapalli, Chandana, Kazlauskaite, Agne, Zhang, Ning, Woodroof, Helen I., Campbell, David G., Gourlay, Robert, Burchell, Lynn, Walden, Helen, Macartney, Thomas J., Deak, Maria, Knebel, Axel, Alessi, Dario R., Muqit, Miratul M. K.

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Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization von Osgerby, Laura, Lai, Yu-Chiang, Thornton, Peter J, Amalfitano, Joseph, Le Duff, Cécile S, Jabeen, Iqra, Kadri, Hachemi, Miccoli, Ageo, Tucker, James H. R, Muqit, Miratul M. K, Mehellou, Youcef

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Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans von Lenka, Dipti Ranjan, Dahe, Shakti Virendra, Antico, Odetta, Sahoo, Pritiranjan, Prescott, Alan R, Muqit, Miratul M K, Kumar, Atul

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mito-QC illuminates mitophagy and mitochondrial architecture in vivo von McWilliams, Thomas G, Prescott, Alan R, Allen, George F G, Tamjar, Jevgenia, Munson, Michael J, Thomson, Calum, Muqit, Miratul M K, Ganley, Ian G

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Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity von Kazlauskaite, Agne, Kelly, Van, Johnson, Clare, Baillie, Carla, Hastie, C. James, Peggie, Mark, Macartney, Thomas, Woodroof, Helen I., Alessi, Dario R., Pedrioli, Patrick G. A., Muqit, Miratul M. K.

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A heterozygous effect for PINK1 mutations in Parkinson's disease? von Abou-Sleiman, Patrick M., Muqit, Miratul M. K., McDonald, Neil Q., Yang, Yan Xiang, Gandhi, Sonia, Healy, Daniel G., Harvey, Kirsten, Harvey, Robert J., Deas, Emma, Bhatia, Kailash, Quinn, Niall, Lees, Andrew, Latchman, David S., Wood, Nicholas W.

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TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency von Flinn, Laura J., Keatinge, Marcus, Bretaud, Sandrine, Mortiboys, Heather, Matsui, Hideaki, De Felice, Elena, Woodroof, Helen I., Brown, Lucy, McTighe, Aimee, Soellner, Rosemarie, Allen, Claire E., Heath, Paul R., Milo, Marta, Muqit, Miratul M. K., Reichert, Andreas S., Köster, Reinhard W., Ingham, Philip W., Bandmann, Oliver

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Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog von Rogerson, Daniel T, Sachdeva, Amit, Wang, Kaihang, Haq, Tamanna, Kazlauskaite, Agne, Hancock, Susan M, Huguenin-Dezot, Nicolas, Muqit, Miratul M K, Fry, Andrew M, Bayliss, Richard, Chin, Jason W

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The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons von Iovino, Mariangela, Pfisterer, Ulrich, Holton, Janice L., Lashley, Tammaryn, Swingler, Robert J., Calo, Laura, Treacy, Rebecca, Revesz, Tamas, Parmar, Malin, Goedert, Michel, Muqit, Miratul M. K., Spillantini, Maria Grazia

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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress von Muqit, Miratul M. K., Abou‐Sleiman, Patrick M., Saurin, Adrian T., Harvey, Kirsten, Gandhi, Sonia, Deas, Emma, Eaton, Simon, Payne Smith, Martin D., Venner, Kerrie, Matilla, Antoni, Healy, Daniel G., Gilks, William P., Lees, Andrew J., Holton, Janice, Revesz, Tamas, Parker, Peter J., Harvey, Robert J., Wood, Nicholas W., Latchman, David S.

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The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1 von Barini, Erica, Miccoli, Ageo, Tinarelli, Federico, Mulholland, Katie, Kadri, Hachemi, Khanim, Farhat, Stojanovski, Laste, Read, Kevin D., Burness, Kerry, Blow, Julian J., Mehellou, Youcef, Muqit, Miratul M. K.

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Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation von Pao, Kuan-Chuan, Stanley, Mathew, Han, Cong, Lai, Yu-Chiang, Murphy, Paul, Balk, Kristin, Wood, Nicola T, Corti, Olga, Corvol, Jean-Christophe, Muqit, Miratul M K, Virdee, Satpal

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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation von Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK

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PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72 von Vieweg, Sophie, Mulholland, Katie, Braeuning, Bastian, Kachariya, Nitin, Lai, Yu-Chiang, Toth, Rachel, Singh, Pawan Kishor, Volpi, Ilaria, Sattler, Michael, Groll, Michael, Itzen, Aymelt, Muqit, Miratul M. K.

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Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies? von Kunath, Tilo, Natalwala, Ammar, Chan, Claire, Chen, Yixi, Stecher, Benjamin, Taylor, Martin, Khan, Sadaquate, Muqit, Miratul M. K.

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Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson’s disease von Miller, Silke, Muqit, Miratul M.K.

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PTEN-induced kinase 1 (PINK1) and Parkin: Unlocking a mitochondrial quality control pathway linked to Parkinson's disease von Agarwal, Shalini, Muqit, Miratul M.K.

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