TLR7 gain-of-function genetic variation causes human lupus von Brown, Grant J., Cañete, Pablo F., Wang, Hao, Medhavy, Arti, Bones, Josiah, Roco, Jonathan A., He, Yuke, Qin, Yuting, Cappello, Jean, Ellyard, Julia I., Bassett, Katharine, Shen, Qian, Burgio, Gaetan, Zhang, Yaoyuan, Turnbull, Cynthia, Meng, Xiangpeng, Wu, Phil, Cho, Eun, Miosge, Lisa A., Andrews, T. Daniel, Field, Matt A., Tvorogov, Denis, Lopez, Angel F., Babon, Jeffrey J., López, Cristina Aparicio, Gónzalez-Murillo, África, Garulo, Daniel Clemente, Pascual, Virginia, Levy, Tess, Mallack, Eric J., Calame, Daniel G., Lotze, Timothy, Lupski, James R., Ding, Huihua, Ullah, Tomalika R., Walters, Giles D., Koina, Mark E., Cook, Matthew C., Shen, Nan, de Lucas Collantes, Carmen, Corry, Ben, Gantier, Michael P., Athanasopoulos, Vicki, Vinuesa, Carola G.

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Comparison of predicted and actual consequences of missense mutations von Miosge, Lisa A., Field, Matthew A., Sontani, Yovina, Cho, Vicky, Johnson, Simon, Palkova, Anna, Balakishnan, Bhavani, Liang, Rong, Zhang, Yafei, Lyon, Stephen, Beutler, Bruce, Whittle, Belinda, Bertram, Edward M., Enders, Anselm, Goodnow, Christopher C., Andrews, T. Daniel

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Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects von Stepensky, Polina, MD, Keller, Baerbel, MSc, Buchta, Mary, Kienzler, Anne-Kathrin, MSc, Elpeleg, Orly, MD, Somech, Raz, MD, PhD, Cohen, Sivan, MSc, Shachar, Idit, PhD, Miosge, Lisa A., PhD, Schlesier, Michael, PhD, Fuchs, Ilka, MSc, Enders, Anselm, MD, Eibel, Hermann, PhD, Grimbacher, Bodo, MD, Warnatz, Klaus, MD

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Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus von Jiang, Simon H., Athanasopoulos, Vicki, Ellyard, Julia I., Chuah, Aaron, Cappello, Jean, Cook, Amelia, Prabhu, Savit B., Cardenas, Jacob, Gu, Jinghua, Stanley, Maurice, Roco, Jonathan A., Papa, Ilenia, Yabas, Mehmet, Walters, Giles D., Burgio, Gaetan, McKeon, Kathryn, Byers, James M., Burrin, Charlotte, Enders, Anselm, Miosge, Lisa A., Canete, Pablo F., Jelusic, Marija, Tasic, Velibor, Lungu, Adrian C., Alexander, Stephen I., Kitching, Arthur R., Fulcher, David A., Shen, Nan, Arsov, Todor, Gatenby, Paul A., Babon, Jeff J., Mallon, Dominic F., de Lucas Collantes, Carmen, Stone, Eric A., Wu, Philip, Field, Matthew A., Andrews, Thomas D., Cho, Eun, Pascual, Virginia, Cook, Matthew C., Vinuesa, Carola G.

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DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns von Skvortsova, Ksenia, Masle-Farquhar, Etienne, Luu, Phuc-Loi, Song, Jenny Z., Qu, Wenjia, Zotenko, Elena, Gould, Cathryn M., Du, Qian, Peters, Timothy J., Colino-Sanguino, Yolanda, Pidsley, Ruth, Nair, Shalima S., Khoury, Amanda, Smith, Grady C., Miosge, Lisa A., Reed, Joanne H., Kench, James G., Rubin, Mark A., Horvath, Lisa, Bogdanovic, Ozren, Lim, Sue Mei, Polo, Jose M., Goodnow, Christopher C., Stirzaker, Clare, Clark, Susan J.

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A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice von Boast, Brigette, Miosge, Lisa A., Kuehn, Hye Sun, Cho, Vicky, Athanasopoulos, Vicki, McNamara, Hayley A., Sontani, Yovina, Mei, Yan, Howard, Debbie, Sutton, Henry J., Omari, Sofia A., Yu, Zhijia, Nasreen, Mariam, Andrews, T. Daniel, Cockburn, Ian A., Goodnow, Christopher C., Rosenzweig, Sergio D., Enders, Anselm

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Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes von Enders, Anslem, Short, Alanna, Miosge, Lisa A., Bergmann, Hannes, Sontani, Yovina, Bertram, Edward M., Whittle, Belinda, Balakishnan, Bhavani, Yoshida, Kaoru, Sjollema, Geoff, Field, Matthew A., Andrews, T. Daniel, Hagiwara, Hiromi, Goodnow, Christopher C.

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Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations von Bull, Katherine R, Rimmer, Andrew J, Siggs, Owen M, Miosge, Lisa A, Roots, Carla M, Enders, Anselm, Bertram, Edward M, Crockford, Tanya L, Whittle, Belinda, Potter, Paul K, Simon, Michelle M, Mallon, Ann-Marie, Brown, Steve D M, Beutler, Bruce, Goodnow, Christopher C, Lunter, Gerton, Cornall, Richard J

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NINJ1 mediates plasma membrane rupture during lytic cell death von Kayagaki, Nobuhiko, Kornfeld, Opher S., Lee, Bettina L., Stowe, Irma B., O’Rourke, Karen, Li, Qingling, Sandoval, Wendy, Yan, Donghong, Kang, Jing, Xu, Min, Zhang, Juan, Lee, Wyne P., McKenzie, Brent S., Ulas, Gözde, Payandeh, Jian, Roose-Girma, Merone, Modrusan, Zora, Reja, Rohit, Sagolla, Meredith, Webster, Joshua D., Cho, Vicky, Andrews, T. Daniel, Morris, Lucy X., Miosge, Lisa A., Goodnow, Christopher C., Bertram, Edward M., Dixit, Vishva M.

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Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis von Jun, Jesse E., Wilson, Lauren E., Vinuesa, Carola G., Lesage, Sylvie, Blery, Mathieu, Miosge, Lisa A., Cook, Matthew C., Kucharska, Edyta M., Hara, Hiromitsu, Penninger, Josef M., Domashenz, Heather, Hong, Nancy A., Glynne, Richard J., Nelms, Keats A., Goodnow, Christopher C.

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Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies von Daley, Stephen R, Coakley, Kristen M, Hu, Daniel Y, Randall, Katrina L, Jenne, Craig N, Limnander, Andre, Myers, Darienne R, Polakos, Noelle K, Enders, Anselm, Roots, Carla, Balakishnan, Bhavani, Miosge, Lisa A, Sjollema, Geoff, Bertram, Edward M, Field, Matthew A, Shao, Yunli, Andrews, T Daniel, Whittle, Belinda, Barnes, S Whitney, Walker, John R, Cyster, Jason G, Goodnow, Christopher C, Roose, Jeroen P

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Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function von Brownlie, Rebecca J, Miosge, Lisa A, Vassilakos, Demetrios, Svensson, Lena M, Cope, Andrew, Zamoyska, Rose

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Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint von Masle-Farquhar, Etienne, Peters, Timothy J., Miosge, Lisa A., Parish, Ian A., Weigel, Christoph, Oakes, Christopher C., Reed, Joanne H., Goodnow, Christopher C.

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Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐NLRP3 inflammasomes von Enosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan, Man, Si Ming

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Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome von Mathur, Anukriti, Kay, Callum, Xue, Yansong, Pandey, Abhimanu, Lee, Jiwon, Jing, Weidong, Enosi Tuipulotu, Daniel, Lo Pilato, Jordan, Feng, Shouya, Ngo, Chinh, Zhao, Anyang, Shen, Cheng, Rug, Melanie, Miosge, Lisa A, Atmosukarto, Ines I, Price, Jason D, Ali, Sidra A, Gardiner, Elizabeth E, Robertson, Avril AB, Awad, Milena M, Lyras, Dena, Kaakoush, Nadeem O, Man, Si Ming

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Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility von Wirasinha, Rushika C., Davies, Ainsley R., Srivastava, Monika, Sheridan, Julie M., Sng, Xavier Y. X., Delmonte, Ottavia M., Dobbs, Kerry, Loh, Khai L., Miosge, Lisa A., Lee, Cindy Eunhee, Chand, Rochna, Chan, Anna, Yap, Jin Yan, Keller, Michael D., Chen, Karin, Rossjohn, Jamie, La Gruta, Nicole L., Vinuesa, Carola G., Reid, Hugh H., Lionakis, Michail S., Notarangelo, Luigi D., Gray, Daniel H. D., Goodnow, Christopher C., Cook, Matthew C., Daley, Stephen R.

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SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells von Nüssing, Simone, Miosge, Lisa A, Lee, Kah, Olshansky, Moshe, Barugahare, Adele, Roots, Carla M, Sontani, Yovina, Day, E Bridie, Koutsakos, Marios, Kedzierska, Katherine, Goodnow, Christopher C, Russ, Brendan E, Daley, Stephen R, Turner, Stephen J

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Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance von Wagle, Mayura V., Vervoort, Stephin J., Kelly, Madison J., Van Der Byl, Willem, Peters, Timothy J., Martin, Ben P., Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James R., Knight, Deborah, Reading, Sinead, Thia, Kevin, Miosge, Lisa A., Howard, Debbie R., Gloury, Renee, Gabriel, Sarah S., Utzschneider, Daniel T., Oliaro, Jane, Powell, Jonathan D., Luciani, Fabio, Trapani, Joseph A., Johnstone, Ricky W., Kallies, Axel, Goodnow, Christopher C., Parish, Ian A.

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Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation von Siggs, Owen M, Miosge, Lisa A, Daley, Stephen R, Asquith, Kelly, Foster, Paul S, Liston, Adrian, Goodnow, Christopher C

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Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion von Miosge, Lisa A., Sontani, Yovina, Chuah, Aaron, Horikawa, Keisuke, Russell, Tiffany A., Mei, Yan, Wagle, Mayura V., Howard, Debbie R., Enders, Anselm, Tscharke, David C., Goodnow, Christopher C., Parish, Ian A.

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