Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape von Hicks, Kristin C., Chariou, Paul L., Ozawa, Yohei, Minnar, Christine M., Knudson, Karin M., Meyer, Thomas J., Bian, Jing, Cam, Margaret, Schlom, Jeffrey, Gameiro, Sofia R.

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Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9 von Chariou, Paul L, Minnar, Christine M, Tandon, Mayank, Guest, Mary R, Chari, Raj, Schlom, Jeffrey, Gameiro, Sofia R

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Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine von Minnar, Christine M, Lui, Grace, Gulley, James L, Schlom, Jeffrey, Gameiro, Sofia R

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Tumor-targeted interleukin-12 synergizes with entinostat to overcome PD-1/PD-L1 blockade-resistant tumors harboring MHC-I and APM deficiencies von Minnar, Christine M, Chariou, Paul L, Horn, Lucas A, Hicks, Kristin C, Palena, Claudia, Schlom, Jeffrey, Gameiro, Sofia R

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Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of Solid Malignancies von Lui, Grace, Minnar, Christine M, Soon-Shiong, Patrick, Schlom, Jeffrey, Gameiro, Sofia R

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Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients von Collins, Craig P, Khuat, Lam T, Sckisel, Gail D, Vick, Logan V, Minnar, Christine M, Dunai, Cordelia, Le, Catherine T, Curti, Brendan D, Crittenden, Marka, Merleev, Alexander, Sheng, Michael, Chao, Nelson J, Maverakis, Emanual, Rosario, Spencer R, Monjazeb, Arta M, Blazar, Bruce R, Longo, Dan L, Canter, Robert J, Murphy, William J

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Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa von Ozawa, Yohei, Hicks, Kristin C., Minnar, Christine M., Knudson, Karin M., Schlom, Jeffrey, Gameiro, Sofia R.

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Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy von Sckisel, Gail D, Mirsoian, Annie, Minnar, Christine M, Crittenden, Marka, Curti, Brendan, Chen, Jane Q, Blazar, Bruce R, Borowsky, Alexander D, Monjazeb, Arta M, Murphy, William J

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade von Wang, Ziming, Aguilar, Ethan G., Luna, Jesus I., Dunai, Cordelia, Khuat, Lam T., Le, Catherine T., Mirsoian, Annie, Minnar, Christine M., Stoffel, Kevin M., Sturgill, Ian R., Grossenbacher, Steven K., Withers, Sita S., Rebhun, Robert B., Hartigan-O’Connor, Dennis J., Méndez-Lagares, Gema, Tarantal, Alice F., Isseroff, R. Rivkah, Griffith, Thomas S., Schalper, Kurt A., Merleev, Alexander, Saha, Asim, Maverakis, Emanual, Kelly, Karen, Aljumaily, Raid, Ibrahimi, Sami, Mukherjee, Sarbajit, Machiorlatti, Michael, Vesely, Sara K., Longo, Dan L., Blazar, Bruce R., Canter, Robert J., Murphy, William J., Monjazeb, Arta M.

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Immunoregulatory pathways following strong inflammatory processes markedly impair CD4+ T cell responses von Minnar, Christine M., Murphy, William J.

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Generation of murine tumor models refractory to [alpha]PD-1/-L1 therapies due to defects in antigen processing/presentation or IFN[gamma] signaling using CRISPR/Cas9 von Chariou, Paul L, Minnar, Christine M, Tandon, Mayank, Guest, Mary R, Chari, Raj, Schlom, Jeffrey, Gameiro, Sofia R

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Abstract P034: Tumor-targeted interleukin-12 and Entinostat combination therapy improves cancer survival by reprogramming the tumor immune cell landscape von Hicks, Kristin C., Chariou, Paul L., Ozawa, Yohei, Minnar, Christine M., Knudson, Karin M., Meyer, Thomas J., Bian, Jing, Cam, Margaret, Schlom, Jeffrey, Gameiro, Sofia R.

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Systemic Stimulatory Cancer Immunotherapy Induces Corticosterone-mediated Thymic Involution von Minnar, Christine Mall, Sckisel, Gail D., Beerthuijzen, Johanna M.T., Aguilar, Ethan G., Mirsoian, Annie, Crittenden, Marka, Blazar, Bruce R., Monjazeb, Arta M., Murphy, William J.

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Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms von Monjazeb, Arta M., Wang, Ziming, Vick, Logan V., Dunai, Cordelia, Minnar, Christine, Khuat, Lam T., Murphy, William J.

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