AB0170 Cytof Analysis of Lip Biopsies from SjÖgren's Subjects Identifies Dysregulated Immune and Non-Immune Cell Subsets von Haskett, S., Boudaoud, S., Reynolds, T., Nocturne, G., Themeles, M., Dunstan, R., Zheng, T., Mingueneau, M., Xavier, M.

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Multiplicity and plasticity of natural killer cell signaling pathways von Chiesa, Sabrina, Mingueneau, Michael, Fuseri, Nicolas, Malissen, Bernard, Raulet, David H., Malissen, Marie, Vivier, Eric, Tomasello, Elena

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Hands-on Experiments on Glycemia Regulation and Type 1 Diabetes von Mingueneau, M, Chaix, A, Scotti, N, Chaix, J, Reynders, A, Hammond, C, Thimonier, J

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A Multidisciplinary Guided Practical on Type I Diabetes Engaging Students in Inquiry-Based Learning von Mingueneau, M, Chaix, A, Scotti, N, Chaix, J, Reynders, A, Hammond, C, Thimonier, J

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Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain von Burns, Jeremy Carlos, Cotleur, Bunny, Walther, Dirk M., Bajrami, Bekim, Rubino, Stephen J., Wei, Ru, Franchimont, Nathalie, Cotman, Susan L., Ransohoff, Richard M., Mingueneau, Michael

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Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation von Mingueneau, Michael, PhD, Boudaoud, Saida, MSc, Haskett, Scott, MSc, Reynolds, Taylor L., DVM, PhD, Nocturne, Gaetane, MD, PhD, Norton, Elizabeth, BSc, Zhang, Xueli, BSc, Constant, Myrtha, BSc, Park, Daniel, MSc, Wang, Wenting, PhD, Lazure, Thierry, MD, Le Pajolec, Christine, MD, Ergun, Ayla, PhD, Mariette, Xavier, MD, PhD

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Novel Potent Selective Orally Active S1P5 Receptor Antagonists von Ma, Bin, Guckian, Kevin M, Liu, Xiao-gao, Yang, Chunhua, Li, Bing, Scannevin, Robert, Mingueneau, Michaël, Drouillard, Annabelle, Walzer, Thierry

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Isolation of Microglia and Analysis of Protein Expression by Flow Cytometry: Avoiding the Pitfall of Microglia Background Autofluorescence von Burns, Jeremy C, Ransohoff, Richard M, Mingueneau, Michaël

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Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome von Kroef, Maarten, Hoogen, Lucas L., Mertens, Jorre S., Blokland, Sofie L.M., Haskett, Scott, Devaprasad, Abhinandan, Carvalheiro, Tiago, Chouri, Eleni, Vazirpanah, Nadia, Cossu, Marta, Wichers, Catherina G.K, Silva‐Cardoso, Sandra C., Affandi, Alsya J., Bekker, Cornelis P.J., Lopes, Ana P., Hillen, Maarten R., Bonte‐Mineur, Femke, Kok, Marc R., Beretta, Lorenzo, Rossato, Marzia, Mingueneau, Michaël, Roon, Joel A.G., Radstake, Timothy R.D.J

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Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation von Delbridge, Alex R. D., Huh, Dann, Brickelmaier, Margot, Burns, Jeremy C., Roberts, Chris, Challa, Ravi, Raymond, Naideline, Cullen, Patrick, Carlile, Thomas M., Ennis, Katelin A., Liu, Mei, Sun, Chao, Allaire, Normand E., Foos, Marianna, Tsai, Hui-Hsin, Franchimont, Nathalie, Ransohoff, Richard M., Butts, Cherie, Mingueneau, Michael

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Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice von Mingueneau, Michael, Krishnaswamy, Smita, Spitzer, Matthew H., Bendall, Sean C., Stone, Erica L., Hedrick, Stephen M., Pe'er, Dana, Mathis, Diane, Nolan, Garry P., Benoist, Christophe

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MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response von Pellerin, Kathryn, Rubino, Stephen J., Burns, Jeremy C., Smith, Benjamin A., Mccarl, Christie-Ann, Zhu, Jing, Jandreski, Luke, Cullen, Patrick, Carlile, Thomas M., Li, Angela, Rebollar, Jorge Vera, Sybulski, Jennifer, Reynolds, Taylor L., Zhang, Baohong, Basile, Rebecca, Tang, Hao, Harp, Chelsea Parker, Pellerin, Alex, Silbereis, John, Franchimont, Nathalie, Cahir-McFarland, Ellen, Ransohoff, Richard M., Cameron, Thomas O., Mingueneau, Michael

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Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors von Ma, Bin, Metrick, Claire M., Gu, Chungang, Hoemberger, Marc, Bajrami, Bekim, Bame, Eris, Huang, Jiansheng, Mingueneau, Michael, Murugan, Paramasivam, Santoro, Joseph C., Tang, Hao, Wang, Ti, Hopkins, Brian T.

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Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis von Hopkins, Brian T, Bame, Eris, Bajrami, Bekim, Black, Cheryl, Bohnert, Tonika, Boiselle, Carrie, Burdette, Doug, Burns, Jeremy C, Delva, Luisette, Donaldson, Douglas, Grater, Richard, Gu, Chungang, Hoemberger, Marc, Johnson, Josh, Kapadnis, Sudarshan, King, Kris, Lulla, Mukesh, Ma, Bin, Marx, Isaac, Magee, Tom, Meissner, Robert, Metrick, Claire M, Mingueneau, Michael, Murugan, Paramasivam, Otipoby, Kevin L, Polack, Evelyne, Poreci, Urjana, Prince, Robin, Roach, Allie M, Rowbottom, Chris, Santoro, Joseph C, Schroeder, Patricia, Tang, Hao, Tien, Eric, Zhang, Fengmei, Lyssikatos, Joseph

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Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model von Wemlinger, Scott M, Parker Harp, Chelsea R, Yu, Bo, Hardy, Ian R, Seefeldt, Matthew, Matsuda, Jennifer, Mingueneau, Michael, Spilker, Kerri A, Cameron, Thomas O, Larrick, James W, Getahun, Andrew, Cambier, John C

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Corrigendum to “Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors” [Bioorg. Med. Chem. Lett. 60 (2022) 128549] von Ma, Bin, Metrick, Claire M., Gu, Chungang, Hoemberger, Marc, Bajrami, Bekim, Bame, Eris, Huang, Jiansheng, Mingueneau, Michael, Murugan, Paramasivam, Nevalainen, Marta, Santoro, Joseph C., Tang, Hao, Wang, Ti, Hopkins, Brian T.

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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis von Himmelbauer, Martin K., Bajrami, Bekim, Basile, Rebecca, Capacci, Andrew, Chen, TeYu, Choi, Colin K., Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix, Gu, Chungang, Hoemberger, Marc, Johnson, Douglas S., Jones, J. Howard, Kadakia, Ekta, Kirkland, Melissa, Lin, Edward Y., Liu, Ying, Ma, Bin, Magee, Tom, Mantena, Srinivasa, Marx, Isaac E., Metrick, Claire M., Mingueneau, Michael, Murugan, Paramasivam, Muste, Cathy A., Nadella, Prasad, Nevalainen, Marta, Parker Harp, Chelsea R., Pattaropong, Vatee, Pietrasiewicz, Alicia, Prince, Robin J., Purgett, Thomas J., Santoro, Joseph C., Schulz, Jurgen, Sciabola, Simone, Tang, Hao, Vandeveer, H. George, Wang, Ti, Yousaf, Zain, Helal, Christopher J., Hopkins, Brian T.

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Next‐generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells... von Bame, Eris, Tang, Hao, Burns, Jeremy C, Arefayene, Million, Michelsen, Klaus, Ma, Bin, Marx, Isaac, Prince, Robin, Roach, Allie M, Poreci, Urjana, Donaldson, Douglas, Cullen, Patrick, Casey, Fergal, Zhu, Jing, Carlile, Thomas M, Sangurdekar, Dipen, Zhang, Baohong, Trapa, Patrick, Santoro, Joseph, Muragan, Param, Pellerin, Alex, Rubino, Stephen, Gianni, Davide, Bajrami, Bekim, Peng, Xiaomei, Coppell, Alex, Riester, Katherine, Belachew, Shibeshih, Mehta, Devangi, Palte, Mike, Hopkins, Brian T, Scaramozza, Matthew, Franchimont, Nathalie, Mingueneau, Michael

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Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor von Mingueneau, Michael, Roncagalli, Romain, Grégoire, Claude, Kissenpfennig, Adrien, Miazek, Arkadiusz, Archambaud, Cristel, Wang, Ying, Perrin, Pierre, Bertosio, Elodie, Sansoni, Amandine, Richelme, Sylvie, Locksley, Richard M., Aguado, Enrique, Malissen, Marie, Malissen, Bernard

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Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development von Wang, Haopeng, Holst, Jeff, Woo, Seng-Ryong, Guy, Cliff, Bettini, Matt, Wang, Yao, Shafer, Aaron, Naramura, Mayumi, Mingueneau, Michaël, Dragone, Leonard L, Hayes, Sandra M, Malissen, Bernard, Band, Hamid, Vignali, Dario A A

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