Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor von Thoma, Gebhard, Miltz, Wolfgang, Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Klein, Kai, Evans, Amanda, Beerli, Christian, Röhn, Till A.

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Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis von Velcicky, Juraj, Miltz, Wolfgang, Oberhauser, Berndt, Orain, David, Vaupel, Andrea, Weigand, Klaus, Dawson King, Janet, Littlewood-Evans, Amanda, Nash, Mark, Feifel, Roland, Loetscher, Pius

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Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase von Thoma, Gebhard, Markert, Christian, Lueoend, Rainer, Miltz, Wolfgang, Spanka, Carsten, Bollbuck, Birgit, Wolf, Romain M., Srinivas, Honnappa, Penno, Carlos A., Kiffe, Michael, Gajewska, Monika, Bednarczyk, Dallas, Wieczorek, Grazyna, Evans, Amanda, Beerli, Christian, Röhn, Till A.

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Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A(4) Hydrolase von Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lueoend, Rainer M., Miltz, Wolfgang, Waelchli, Rudolf, Wolf, Romain, Hinrichs, Juergen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A., Klein, Kai, Wack, Nathalie, Jaeger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Roehn, Till A.

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Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis von Miltz, Wolfgang, Velcicky, Juraj, Dawson, Janet, Littlewood-Evans, Amanda, Ludwig, Marie-Gabrielle, Seuwen, Klaus, Feifel, Roland, Oberhauser, Berndt, Meyer, Arndt, Gabriel, Daniela, Nash, Mark, Loetscher, Pius

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Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors von Numao, Shin, Hasler, Franziska, Laguerre, Claire, Srinivas, Honnappa, Wack, Nathalie, Jäger, Petra, Schmid, Andres, Osmont, Arnaud, Röthlisberger, Patrik, Houguenade, Jeremy, Bergsdorf, Christian, Dawson, Janet, Carte, Nathalie, Hofmann, Andreas, Markert, Christian, Hardaker, Liz, Billich, Andreas, Wolf, Romain M., Penno, Carlos A., Bollbuck, Birgit, Miltz, Wolfgang, Röhn, Till A.

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Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase von Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lüönd, Rainer M, Miltz, Wolfgang, Wälchli, Rudolf, Wolf, Romain, Hinrichs, Jürgen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A, Klein, Kai, Wack, Nathalie, Jäger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Röhn, Till A

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Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase von Markert, Christian, Thoma, Gebhard, Srinivas, Honnappa, Bollbuck, Birgit, Lüönd, Rainer M, Miltz, Wolfgang, Wälchli, Rudolf, Wolf, Romain, Hinrichs, Jürgen, Bergsdorf, Christian, Azzaoui, Kamal, Penno, Carlos A, Klein, Kai, Wack, Nathalie, Jäger, Petra, Hasler, Franziska, Beerli, Christian, Loetscher, Pius, Dawson, Janet, Wieczorek, Grazyna, Numao, Shin, Littlewood-Evans, Amanda, Röhn, Till A

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Targeting monocyte chemoattractant protein-1 signalling in disease von Dawson, Janet, Miltz, Wolfgang, Mir, Anis K, Wiessner, Christoph

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A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors von Janser, Philipp, Neumann, Ulf, Miltz, Wolfgang, Feifel, Roland, Buhl, Thomas

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NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES von MILTZ, Wolfgang, ROEHN, Till, BOLLBUCK, Birgit, MARKERT, Christian

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Heteroaryl butanoic acid derivatives von Miltz, Wolfgang, Markert, Christian, Bollbuck, Birgit, Roehn, Till

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Novel Heteroaryl Aminopropanol Derivatives von Liu, Yugang, Miltz, Wolfgang, Spanka, Carsten, Thoma, Gebhard, Markert, Christian, Lüönd, Rainer Martin, XIE, Tian, Kordikowski, Andreas, Roehn, Till

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NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES von MILTZ, Wolfgang, ROEHN, Till, BOLLBUCK, Birgit, MARKERT, Christian

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Heteroaryl aminopropanol derivatives von Liu, Yugang, Miltz, Wolfgang, Spanka, Carsten, Thoma, Gebhard, Xie, Tian, Markert, Christian, Lüönd, Rainer Martin, Kordikowski, Andreas, Roehn, Till

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HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H von SPANKA, Carsten, KORDIKOWSKI, Andreas, LÜÖND, Rainer Martin, MILTZ, Wolfgang, ROEHN, Till, THOMA, Gebhard, LIU, Yugang, XIE, Tian, MARKERT, Christian

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HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H von SPANKA, Carsten, KORDIKOWSKI, Andreas, LÜÖND, Rainer Martin, MILTZ, Wolfgang, ROEHN, Till, THOMA, Gebhard, LIU, Yugang, XIE, Tian, MARKERT, Christian

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Novel Heteroaryl Aminopropanol Derivatives von Liu, Yugang, Miltz, Wolfgang, Spanka, Carsten, Thoma, Gebhard, Markert, Christian, Lüönd, Rainer Martin, XIE, Tian, Kordikowski, Andreas, Roehn, Till

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HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H von LIU, YUGANG, XIE, TIAN, SPANKA, CARSTEN, KORDIKOWSKI, ANDREAS, MARKERT, CHRISTIAN, THOMA, GEBHARD, ROEHN, TILL, MILTZ, WOLFGANG, LUOND, RAINER MARTIN

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HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H von SPANKA, Carsten, KORDIKOWSKI, Andreas, LÜÖND, Rainer Martin, MILTZ, Wolfgang, ROEHN, Till, THOMA, Gebhard, LIU, Yugang, XIE, Tian, MARKERT, Christian

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