Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology von Devalla, Harsha D, Schwach, Verena, Ford, John W, Milnes, James T, El‐Haou, Said, Jackson, Claire, Gkatzis, Konstantinos, Elliott, David A, Chuva de Sousa Lopes, Susana M, Mummery, Christine L, Verkerk, Arie O, Passier, Robert

Volltext

Extended lifetime MCP-PMTs: Characterisation and lifetime measurements of ALD coated microchannel plates, in a sealed photomultiplier tube von Conneely, Thomas M., Milnes, James S., Howorth, Jon

Volltext

Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation von van Hunnik, Arne, Sobota, Vladimír, Zeemering, Stef, Opacic, Dragan, Scaf, Billy, D'Alessandro, Elisa, Oyaert, Karel, Kuiper, Marion, Diness, Jonas G, Sørensen, Ulrik S, Milnes, James T, van der Heyden, Marcel A G, Jespersen, Thomas, Schotten, Ulrich, Verheule, Sander

Volltext

New Drugs Targeting the Cardiac Ultra-Rapid Delayed-Rectifier Current (IKur): Rationale, Pharmacology and Evidence for Potential Therapeutic Value von Ford, John W, Milnes, James T

Volltext

Novel K+ Channel Targets in Atrial Fibrillation Drug Development—Where Are We? von El-Haou, Said, Ford, John W, Milnes, James T

Volltext

The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation von Ford, John, PhD, Milnes, James, PhD, El Haou, Said, PhD, Wettwer, Erich, PhD, Loose, Simone, MD, Matschke, Klaus, MD, Tyl, Benoit, MD, Round, Patrick, MBBS, Ravens, Ursula, MD

Volltext

The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats von Sobota, Vladimir, Gatta, Giulia, van Hunnik, Arne, van Tuijn, Iris, Kuiper, Marion, Milnes, James, Jespersen, Thomas, Schotten, Ulrich, Verheule, Sander

Volltext

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652 von Milnes, James T, Crociani, Olivia, Arcangeli, Annarosa, Hancox, Jules C, Witchel, Harry J

Volltext

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes von Caves, Rachel E., Carpenter, Alexander, Choisy, Stéphanie C., Clennell, Ben, Cheng, Hongwei, McNiff, Cameron, Mann, Brendan, Milnes, James T., Hancox, Jules C., James, Andrew F.

Volltext

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current ( I K,ACh ) von Veerman, Christiaan C, Mengarelli, Isabella, Koopman, Charlotte D, Wilders, Ronald, van Amersfoorth, Shirley C, Bakker, Diane, Wolswinkel, Rianne, Hababa, Mariam, de Boer, Teun P, Guan, Kaomei, Milnes, James, Lodder, Elisabeth M, Bakkers, Jeroen, Verkerk, Arie O, Bezzina, Connie R

Volltext

New pharmacological approaches to atrial fibrillation von Milnes, James T., Madge, David J., Ford, John W.

Volltext

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide von Milnes, James T, Witchel, Harry J, Leaney, Joanne L, Leishman, Derek J, Hancox, Jules C

Volltext

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 °C: Cisapride versus dofetilide von Milnes, James T., Witchel, Harry J., Leaney, Joanne L., Leishman, Derek J., Hancox, Jules C.

Volltext

High affinity HERG K + channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656 von Ridley, John M., Milnes, James T., Witchel, Harry J., Hancox, Jules C.

Volltext

The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping von Witchel, Harry J, Dempsey, Christopher E, Sessions, Richard B, Perry, Matthew, Milnes, James T, Hancox, Jules C, Mitcheson, John S

Volltext

hERG K + channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656 von Milnes, James T., Witchel, Harry J., Leaney, Joanne L., Leishman, Derek J., Hancox, Jules C.

Volltext

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia von Kim, Shang-Jin, Zhang, Haifei, Khaliulin, Igor, Choisy, Stéphanie C.M, Bond, Richard, Lin, Hua, El Haou, Said, Milnes, James T, Hancox, Jules C, Suleiman, M Saadeh, James, Andrew F

Volltext

A 256 channel photon counting module using a square microchannel plate PMT in a tight packing envelop achieving <100 ps single photon timing von Milnes, James, Duran, Ayse, Conneely, Thomas, Hink, Paul

Volltext

The N588K-HERG K + channel mutation in the ‘short QT syndrome’: Mechanism of gain-in-function determined at 37 °C von McPate, Mark J., Duncan, Rona S., Milnes, James T., Witchel, Harry J., Hancox, Jules C.

Volltext

Inhibition of the HERG K + channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656 von Ridley, John M., Milnes, James T., Duncan, Rona S., McPate, Mark J., James, Andrew F., Witchel, Harry J., Hancox, Jules C.

Volltext