Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation von Milne, Julia V., Zhang, Bonnie Z., Fujihara, Kenji M., Dawar, Swati, Phillips, Wayne A., Clemons, Nicholas J.

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Modelling esophageal adenocarcinoma and Barrett's esophagus with patient-derived organoids von Milne, Julia V, Mustafa, Ebtihal H, Clemons, Nicholas J

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Caspase-2 protects against ferroptotic cell death von Dawar, Swati, Benitez, Mariana C., Lim, Yoon, Dite, Toby A., Yousef, Jumana M., Thio, Niko, Garciaz, Sylvain, Jackson, Thomas D., Milne, Julia V., Dagley, Laura F., Phillips, Wayne A., Kumar, Sharad, Clemons, Nicholas J.

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Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s Esophagus von Gotovac, Jovana R., Kader, Tanjina, Milne, Julia V., Fujihara, Kenji M., Lara-Gonzalez, Luis E., Gorringe, Kylie L., Kalimuthu, Sangeetha N., Jayawardana, Madawa W., Duong, Cuong P., Phillips, Wayne A., Clemons, Nicholas J.

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GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma von Gotovac, Jovana R, Liu, David SH, Yates, Michael J, Milne, Julia V, Macpherson, Arthi A, Simpson, Kaylene J, Eslick, Guy D, Mitchell, Catherine, Duong, Cuong P, Phillips, Wayne A, Clemons, Nicholas J

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Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer von Cabalag, Carlos S., Prall, Owen W. J., Ciciulla, John, Galea, Laurence A., Thio, Niko, Jayawardana, Madawa, Leong, Trishe Y. M., Milne, Julia V., Fujihara, Kenji M., Chong, Lynn, Hii, Michael W., Arnau, Gisela Mir, Neeson, Paul J., Phillips, Wayne A., Duong, Cuong P., Clemons, Nicholas J.

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Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction von Fujihara, Kenji M., Zhang, Bonnie Z., Jackson, Thomas D., Ogunkola, Moses O., Nijagal, Brunda, Milne, Julia V., Sallman, David A., Ang, Ching-Seng, Nikolic, Iva, Kearney, Conor J., Hogg, Simon J., Cabalag, Carlos S., Sutton, Vivien R., Watt, Sally, Fujihara, Asuka T., Trapani, Joseph A., Simpson, Kaylene J., Stojanovski, Diana, Leimkühler, Silke, Haupt, Sue, Phillips, Wayne A., Clemons, Nicholas J.

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ASO Visual Abstract: Tumor-Infiltrating Neutrophils after Neoadjuvant Therapy are Associated with Poor Prognosis in Esophageal Cancer von Cabalag, Carlos S., Prall, Owen W. J., Ciciulla, John, Galea, Laurence A., Thio, Niko, Jayawardana, Madawa, Leong, Trishe Y. M., Milne, Julia V., Fujihara, Kenji M., Chong, Lynn, Hii, Michael W., Mir Arnau, Gisela, Neeson, Paul J., Phillips, Wayne A., Duong, Cuong P., Clemons, Nicholas J.

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Abstract 2671: SMAD4 as a potential gatekeeper for genomic instability and mTOR-mediated tumorigenesis in esophageal adenocarcinoma von Milne, Julia V., Gotovac, Jovana R., Fujihara, Kenji M., Duong, Cuong P., Phillips, Wayne A., Clemons, Nicholas J.

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Abstract A176: Loss of SMAD4 unleashes mTOR and increases dependency on cap-dependent translation in esophageal tumorigenesis von Milne, Julia V, Mustafa, Ebtihal, Fujihara, Kenji, Kusnadi, Eric, Thio, Niko, Pechlivanis, Maree, Cabalag, Carlos, Gulati, Twishi, Simpson, Kaylene, Duong, Cuong, Furic, Luc, Phillips, Wayne, Clemons, Nicholas J

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Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s EsophagusSummary von Jovana R. Gotovac, Tanjina Kader, Julia V. Milne, Kenji M. Fujihara, Luis E. Lara-Gonzalez, Kylie L. Gorringe, Sangeetha N. Kalimuthu, Madawa W. Jayawardana, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons

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Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol von Gerayeli, Firoozeh V, Milne, Stephen, Yang, Chen Xi, Li, Xuan, Guinto, Elizabeth, Yang, Julia Shun-Wei, Cheung, Chung Yan, Stach, Tara R, Shaipanich, Tawimas, Leung, Janice M, Sin, Don D

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Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1 von Michailidou, Kyriaki, Edwards, Stacey L., Prathalingham, Radhika, Dennis, Joe, de Santiago, Ines, Hopper, John L., Van ’t Veer, Laura J., Hogervorst, Frans B., Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A., Lux, Michael P., Peto, Julian, dos Santos Silva, Isabel, Johnson, Nichola, Miller, Nicola, Marme, Federick, Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Børge G., Flyger, Henrik, Zamora, M. Pilar, Benitez, Javier, Ziogas, Argyrios, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Schmutzler, Rita K., Engel, Christoph, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon-Dschun, Muranen, Taru A., Blomqvist, Carl, Matsuo, Keitaro, Dörk, Thilo, Helbig, Sonja, Bogdanova, Natalia V., Lindblom, Annika, Mannermaa, Arto, Wu, Anna H., Stram, Daniel O., Thienpont, Bernard, Christiaens, Marie-Rose, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bernard, Loris, Wang, Xianshu, Purrington, Kristen, Severi, Gianluca, Baglietto, Laura, McLean, Catriona, Henderson, Brian E., Simard, Jacques, Goldberg, Mark S., Labrèche, France, Yip, Cheng-Har, Phuah, Sze-Yee, Grenaker Alnæs, Grethe, Børresen-Dale, Anne-Lise, Pylkäs, Katri, Kauppila, Saila, Knight, Julia A., Devilee, Peter, Seynaeve, Caroline M., García-Closas, Montserrat, Figueroa, Jonine, Czene, Kamila, Darabi, Hartef, Hooning, Maartje J., Martens, John W.M., van den Ouweland, Ans M.W., Li, Jingmei, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Reed, Malcolm W.R., Signorello, Lisa B., Pharoah, Paul D.P., Ghoussaini, Maya, Choi, Ji-Yeob, Noh, Dong-Young, Hui, Miao, Ulmer, Hans-Ulrich, Jakubowska, Anna, Lubinski, Jan, Durda, Katarzyna, McKay, James, Slager, Susan, Shen, Chen-Yang, Hou, Ming-Feng, Swerdlow, Anthony, Ashworth, Alan, Schoemaker, Minouk J., Dunning, Alison M.

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Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies von YANG, Xiaohong R, CHANG-CLAUDE, Jenny, FASCHING, Peter A, HEIN, Rebecca, SPURDLE, Amanda B, BLOWS, Fiona, DRIVER, Kristy, FLESCH-JANYS, Dieter, HEINZ, Judith, SINN, Peter, VRIELING, Alina, HEIKKINEN, Tuomas, GOODE, Ellen L, AITTOMÄKI, Kristiina, HEIKKILÄ, Paivi, BLOMQVIST, Carl, LISSOWSKA, Jolanta, PEPLONSKA, Beata, CHANOCK, Stephen, FIGUEROA, Jonine, BRINTON, Louise, HALL, Per, CZENE, Kamila, COUCH, Fergus J, HUMPHREYS, Keith, DARABI, Hatef, JIANJUN LIU, VAN 'T VEER, Laura J, VAN LEEUWEN, Flora E, ANDRULIS, Irene L, GLENDON, Gord, KNIGHT, Julia A, MULLIGAN, Anna Marie, O'MALLEY, Frances P, NEVANLINNA, Heli, WEERASOORIYA, Nayana, JOHN, Esther M, BECKMANN, Matthias W, HARTMANN, Arndt, WEIHBRECHT, Sebastian B, WACHTER, David L, JUD, Sebastian M, LOEHBERG, Christian R, BAGLIETTO, Laura, ENGLISH, Dallas R, MILNE, Roger L, GILES, Graham G, MCLEAN, Catriona A, SEVERI, Gianluca, LAMBRECHTS, Diether, VANDORPE, Thijs, WELTENS, Caroline, PARIDAENS, Robert, SMEETS, Ann, NEVEN, Patrick, GAUDET, Mia, SCHMIDT, Marjanka K, BROEKS, Annegien, COX, Angela

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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent von Guo, Yan, Warren Andersen, Shaneda, Shu, Xiao-Ou, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Garcia-Closas, Montserrat, Milne, Roger L, Schmidt, Marjanka K, Chang-Claude, Jenny, Dunning, Allison, Bojesen, Stig E, Ahsan, Habibul, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bogdanova, Natalia V, Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brand, Judith, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Burwinkel, Barbara, Casey, Graham, Chenevix-Trench, Georgia, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dumont, Martine, Fasching, Peter A, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Gammon, Marilie, Giles, Graham G, Guénel, Pascal, Haiman, Christopher A, Hamann, Ute, Hooning, Maartje J, Hopper, John L, Jakubowska, Anna, Jasmine, Farzana, Jenkins, Mark, John, Esther M, Johnson, Nichola, Jones, Michael E, Kabisch, Maria, Kibriya, Muhammad, Knight, Julia A, Koppert, Linetta B, Kosma, Veli-Matti, Kristensen, Vessela, Le Marchand, Loic, Lee, Eunjung, Li, Jingmei, Lindblom, Annika, Luben, Robert, Lubinski, Jan, Malone, Kathi E, Mannermaa, Arto, Margolin, Sara, Marme, Frederik, McLean, Catriona, Meijers-Heijboer, Hanne, Meindl, Alfons, Neuhausen, Susan L, Nevanlinna, Heli, Neven, Patrick, Olson, Janet E, Perez, Jose I A, Perkins, Barbara, Peterlongo, Paolo, Phillips, Kelly-Anne, Pylkäs, Katri, Rudolph, Anja, Santella, Regina, Sawyer, Elinor J, Schmutzler, Rita K, Seynaeve, Caroline, Shah, Mitul, Shrubsole, Martha J, Southey, Melissa C, Swerdlow, Anthony J, Toland, Amanda E, Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Ursin, Giske, Van Der Luijt, Rob B, Verhoef, Senno

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Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors von Nickels, Stefan, Truong, Thérèse, Hein, Rebecca, Stevens, Kristen, Buck, Katharina, Behrens, Sabine, Eilber, Ursula, Schmidt, Martina, Häberle, Lothar, Vrieling, Alina, Gaudet, Mia, Figueroa, Jonine, Schoof, Nils, Spurdle, Amanda B, Rudolph, Anja, Fasching, Peter A, Hopper, John L, Makalic, Enes, Schmidt, Daniel F, Southey, Melissa C, Beckmann, Matthias W, Ekici, Arif B, Fletcher, Olivia, Gibson, Lorna, Silva, Isabel dos Santos, Peto, Julian, Humphreys, Manjeet K, Wang, Jean, Cordina-Duverger, Emilie, Menegaux, Florence, Nordestgaard, Børge G, Bojesen, Stig E, Lanng, Charlotte, Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Clarke, Christina A, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Stegmaier, Christa, Brauch, Hiltrud, Brüning, Thomas, Harth, Volker, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Lambrechts, Diether, Smeets, Dominiek, Neven, Patrick, Paridaens, Robert, Flesch-Janys, Dieter, Obi, Nadia, Wang-Gohrke, Shan, Couch, Fergus J, Olson, Janet E, Vachon, Celine M, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, Offit, Kenneth, John, Esther M, Miron, Alexander, Andrulis, Irene L, Knight, Julia A, Glendon, Gord, Mulligan, Anna Marie, Chanock, Stephen J, Lissowska, Jolanta, Liu, Jianjun, Cox, Angela, Cramp, Helen, Connley, Dan, Balasubramanian, Sabapathy, Dunning, Alison M, Shah, Mitul, Trentham-Dietz, Amy, Newcomb, Polly, Titus, Linda, Egan, Kathleen, Cahoon, Elizabeth K, Rajaraman, Preetha, Sigurdson, Alice J, Doody, Michele M, Guénel, Pascal, Pharoah, Paul D P, Schmidt, Marjanka K, Hall, Per, Easton, Doug F, Garcia-Closas, Montserrat, Milne, Roger L, Chang-Claude, Jenny

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Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers von Ghoussaini, Maya, Edwards, Stacey L., Meyer, Kerstin B., Ahmed, Shahana, Betts, Joshua A., Dicks, Ed, Beesley, Jonathan, Tyrer, Jonathan, Barnes, Daniel, Alonso, M. Rosario, Tessier, Daniel C., Luccarini, Craig, Baynes, Caroline, Bolla, Manjeet K., Wang, Qin, Southey, Melissa C., Schmidt, Marjanka K., Broeks, Annegien, Verhoef, Senno, Cornelissen, Sten, Muir, Kenneth, Lophatananon, Artitaya, Siriwanarangsan, Pornthep, Loehberg, Christian R., Ekici, Arif B., dos Santos Silva, Isabel, Johnson, Nichola, Tomlinson, Ian, Truong, Thérèse, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Benitez, Javier, Anton-Culver, Hoda, Brenner, Hermann, Stegmaier, Christa, Meindl, Alfons, Aittomäki, Kristiina, Matsuo, Keitaro, Iwata, Hiroji, Antonenkova, Natalia N., Dörk, Thilo, Mannermaa, Arto, Stram, Daniel O., Floris, Giuseppe, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Bonanni, Bernardo, Couch, Fergus J., Pankratz, Vernon S., Giles, Graham G., Severi, Gianluca, Haiman, Christopher A., Schumacher, Fredrick, Simard, Jacques, Goldberg, Mark S., Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Pylkäs, Katri, Glendon, Gord, Seynaeve, Caroline, Figueroa, Jonine, Lissowska, Jolanta, Schoof, Nils, Martens, John W.M., Collée, J. Margriet, Tilanus-Linthorst, Madeleine, Hall, Per, Humphreys, Keith, Shu, Xiao-Ou, Gao, Yu-Tang, Cai, Hui, Cox, Angela, Balasubramanian, Sabapathy P., Blot, William, Pharoah, Paul D.P., Healey, Catherine S., Pooley, Karen A., Yoo, Keun-Young, Miao, Hui, Sim, Xueling, Jaworska-Bieniek, Katarzyna, Gaborieau, Valerie, Toland, Amanda E., Chen, Shou-Tung, Swerdlow, Anthony, Ashworth, Alan, Schoemaker, Minouk J., Nevanlinna, Heli, Chenevix-Trench, Georgia, Easton, Douglas F., Dunning, Alison M.

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Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression von Darabi, Hatef, McCue, Karen, Beesley, Jonathan, Michailidou, Kyriaki, Nord, Silje, Kar, Siddhartha, Humphreys, Keith, Bolla, Manjeet K., Dennis, Joe, Canisius, Sander, Apicella, Carmel, Hopper, John L., Southey, Melissa C., Stone, Jennifer, Broeks, Annegien, Schmidt, Marjanka K., Lophatananon, Artitaya, Muir, Kenneth, Fasching, Peter A., Heusinger, Katharina, dos-Santos-Silva, Isabel, Peto, Julian, Tomlinson, Ian, Sawyer, Elinor J., Burwinkel, Barbara, Truong, Thérèse, González-Neira, Anna, Anton-Culver, Hoda, Neuhausen, Susan L., Arndt, Volker, Brenner, Hermann, Engel, Christoph, Meindl, Alfons, Schmutzler, Rita K., Brauch, Hiltrud, Hamann, Ute, Chang-Claude, Jenny, Nevanlinna, Heli, Ito, Hidemi, Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Kosma, Veli-Matti, Mannermaa, Arto, Tseng, Chiu-chen, Floris, Giuseppe, Peterlongo, Paolo, Radice, Paolo, Couch, Fergus J., Vachon, Celine, McLean, Catriona, Milne, Roger L., Dugué, Pierre-Antoine, Haiman, Christopher A., Maskarinec, Gertraud, Woolcott, Christy, Henderson, Brian E., Goldberg, Mark S., Teo, Soo H., Mariapun, Shivaani, Helland, Åslaug, Haakensen, Vilde, Beeghly-Fadiel, Alicia, Tamimi, Rulla, Jukkola-Vuorinen, Arja, Winqvist, Robert, Andrulis, Irene L., Knight, Julia A., Devilee, Peter, Tollenaar, Robert A.E.M., Figueroa, Jonine, García-Closas, Montserrat, Czene, Kamila, Hooning, Maartje J., Tilanus-Linthorst, Madeleine, Gao, Yu-Tang, Shu, Xiao-Ou, Cox, Angela, Luben, Robert, Choi, Ji-Yeob, Kang, Daehee, Hartman, Mikael, Lim, Wei Yen, Kabisch, Maria, Torres, Diana, Jakubowska, Anna, McKay, James, Sangrajrang, Suleeporn, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen-Yang, Yu, Jyh-Cherng, Ziogas, Argyrios, Schoemaker, Minouk J., Swerdlow, Anthony, Borresen-Dale, Anne-Lise, French, Juliet D., Edwards, Stacey L., Easton, Douglas F., Hall, Per

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Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1 von Maranian, Mel J., Kar, Siddhartha, O’Reilly, Martin, Betts, Joshua A., Hillman, Kristine M., Kaufmann, Susanne, Canisius, Sander, Southey, Melissa C., Schmidt, Marjanka K., Hogervorst, Frans B., Muir, Kenneth, Ruebner, Matthias, Beckmann, Matthias W., Fletcher, Olivia, Bolla, Manjeet K., Wang, Qin, Sawyer, Elinor J., Tomlinson, Ian, Miller, Nicola, Burwinkel, Barbara, Yang, Rongxi, Surowy, Harald, Truong, Thérèse, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, González-Neira, Anna, Benitez, Javier, Brenner, Hermann, Dieffenbach, Aida Karina, Meindl, Alfons, Schmutzler, Rita K., Brauch, Hiltrud, Nevanlinna, Heli, Muranen, Taru A., Blomqvist, Carl, Bogdanova, Natalia V., Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Tseng, Chiu-chen, Van Den Berg, David, Lambrechts, Diether, Zhao, Hui, Weltens, Caroline, van Limbergen, Erik, Flesch-Janys, Dieter, Rudolph, Anja, Radice, Paolo, Capra, Fabio, Couch, Fergus J., Vachon, Celine, Haiman, Christopher A., Le Marchand, Loic, Simard, Jacques, Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Ikram, M. Kamran, Kristensen, Vessela, Shrubsole, Martha, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Tollenaar, Robert A.E.M., Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Darabi, Hatef, Eriksson, Mikael, Martens, John W.M., Collée, J. Margriet, Shu, Xiao-Ou, Noh, Dong-Young, Hartman, Mikael, Hamann, Ute, Jaworska, Katarzyna, Durda, Katarzyna, Brennan, Paul, Olswold, Curtis, Slager, Susan, Yannoukakos, Drakoulis, Shen, Chen-Yang, Yu, Jyh-Cherng, Swerdlow, Anthony, Orr, Nick, Jones, Michael, Pita, Guillermo, Herrero, Daniel, Vincent, Daniel, Bacot, Francois, Ahmed, Shahana, Ponder, Bruce A.J., Chenevix-Trench, Georgia, Easton, Douglas F., French, Juliet D.

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A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density von Rudolph, Anja, Fasching, Peter A, Behrens, Sabine, Eilber, Ursula, Bolla, Manjeet K, Wang, Qin, Thompson, Deborah, Czene, Kamila, Brand, Judith S, Li, Jingmei, Scott, Christopher, Pankratz, V Shane, Brandt, Kathleen, Hallberg, Emily, Olson, Janet E, Lee, Adam, Beckmann, Matthias W, Ekici, Arif B, Haeberle, Lothar, Maskarinec, Gertraud, Le Marchand, Loic, Schumacher, Fredrick, Milne, Roger L, Knight, Julia A, Apicella, Carmel, Southey, Melissa C, Kapuscinski, Miroslav K, Hopper, John L, Andrulis, Irene L, Giles, Graham G, Haiman, Christopher A, Khaw, Kay-Tee, Luben, Robert, Hall, Per, Pharoah, Paul D P, Couch, Fergus J, Easton, Douglas F, Dos-Santos-Silva, Isabel, Vachon, Celine, Chang-Claude, Jenny

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