Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity von Hafner, Marc, Mills, Caitlin E., Subramanian, Kartik, Chen, Chen, Chung, Mirra, Boswell, Sarah A., Everley, Robert A., Liu, Changchang, Walmsley, Charlotte S., Juric, Dejan, Sorger, Peter K.

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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype von Olson, Calla M., Liang, Yanke, Leggett, Alan, Park, Woojun D., Li, Lianbo, Mills, Caitlin E., Elsarrag, Selma Z., Ficarro, Scott B., Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A., Sorger, Peter K., Westover, Ken D., Lin, Charles Y., Kwiatkowski, Nicholas, Gray, Nathanael S.

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Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop von Mills, Caitlin E., Subramanian, Kartik, Hafner, Marc, Niepel, Mario, Gerosa, Luca, Chung, Mirra, Victor, Chiara, Gaudio, Benjamin, Yapp, Clarence, Nirmal, Ajit J., Clark, Nicholas, Sorger, Peter K.

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The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification von Wells, Carrow I, Al-Ali, Hassan, Andrews, David M, Asquith, Christopher R M, Axtman, Alison D, Dikic, Ivan, Ebner, Daniel, Ettmayer, Peter, Fischer, Christian, Frederiksen, Mathias, Futrell, Robert E, Gray, Nathanael S, Hatch, Stephanie B, Knapp, Stefan, Lücking, Ulrich, Michaelides, Michael, Mills, Caitlin E, Müller, Susanne, Owen, Dafydd, Picado, Alfredo, Saikatendu, Kumar S, Schröder, Martin, Stolz, Alexandra, Tellechea, Mariana, Turunen, Brandon J, Vilar, Santiago, Wang, Jinhua, Zuercher, William J, Willson, Timothy M, Drewry, David H

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Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes von Doherty, Laura M, Mills, Caitlin E, Boswell, Sarah A, Liu, Xiaoxi, Hoyt, Charles Tapley, Gyori, Benjamin, Buhrlage, Sara J, Sorger, Peter K

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Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity von Melms, Johannes C, Vallabhaneni, Sreeram, Mills, Caitlin E, Yapp, Clarence, Chen, Jia-Yun, Morelli, Eugenio, Waszyk, Patricia, Kumar, Sushil, Deming, Derrick, Moret, Nienke, Rodriguez, Steven, Subramanian, Kartik, Rogava, Meri, Cartwright, Adam N R, Luoma, Adrienne, Mei, Shaolin, Brinker, Titus J, Miller, David M, Spektor, Alexander, Schadendorf, Dirk, Riggi, Nicolo, Wucherpfennig, Kai W, Sorger, Peter K, Izar, Benjamin

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Proteomic profiling across breast cancer cell lines and models von Kalocsay, Marian, Berberich, Matthew J., Everley, Robert A., Nariya, Maulik K., Chung, Mirra, Gaudio, Benjamin, Victor, Chiara, Bradshaw, Gary A., Eisert, Robyn J., Hafner, Marc, Sorger, Peter K., Mills, Caitlin E., Subramanian, Kartik

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Development of CDK2 and CDK5 Dual Degrader TMX‐2172 von Teng, Mingxing, Jiang, Jie, He, Zhixiang, Kwiatkowski, Nicholas P., Donovan, Katherine A., Mills, Caitlin E., Victor, Chiara, Hatcher, John M., Fischer, Eric S., Sorger, Peter K., Zhang, Tinghu, Gray, Nathanael S.

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Development and Characterization of a Wee1 Kinase Degrader von Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K., Fischer, Eric S., Gray, Nathanael S.

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Temporal and spatial topography of cell proliferation in cancer von Gaglia, Giorgio, Kabraji, Sheheryar, Rammos, Danae, Dai, Yang, Verma, Ana, Wang, Shu, Mills, Caitlin E., Chung, Mirra, Bergholz, Johann S., Coy, Shannon, Lin, Jia-Ren, Jeselsohn, Rinath, Metzger, Otto, Winer, Eric P., Dillon, Deborah A., Zhao, Jean J., Sorger, Peter K., Santagata, Sandro

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Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1 -Deficient Cells von Färkkilä, Anniina, Rodríguez, Alfredo, Oikkonen, Jaana, Gulhan, Doga C, Nguyen, Huy, Domínguez, Julieta, Ramos, Sandra, Mills, Caitlin E, Pérez-Villatoro, Fernando, Lazaro, Jean-Bernard, Zhou, Jia, Clairmont, Connor S, Moreau, Lisa A, Park, Peter J, Sorger, Peter K, Hautaniemi, Sampsa, Frias, Sara, D'Andrea, Alan D

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Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7) von Ji, Wenzhi, Du, Guangyan, Jiang, Jie, Lu, Wenchao, Mills, Caitlin E., Yuan, Linjie, Jiang, Fen, He, Zhixiang, Bradshaw, Gary A., Chung, Mirra, Jiang, Zixuan, Byun, Woong Sub, Hinshaw, Stephen M., Zhang, Tinghu, Gray, Nathanael S.

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Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing von Liu, Yan, Ferguson, Fleur M., Li, Lianbo, Kuljanin, Miljan, Mills, Caitlin E., Subramanian, Kartik, Harshbarger, Wayne, Gondi, Sudershan, Wang, Jinhua, Sorger, Peter K., Mancias, Joseph D., Gray, Nathanael S., Westover, Kenneth D.

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A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines von Niepel, Mario, Hafner, Marc, Mills, Caitlin E., Subramanian, Kartik, Williams, Elizabeth H., Chung, Mirra, Gaudio, Benjamin, Barrette, Anne Marie, Stern, Alan D., Hu, Bin, Korkola, James E., Shamu, Caroline E., Jayaraman, Gomathi, Azeloglu, Evren U., Iyengar, Ravi, Sobie, Eric A., Mills, Gordon B., Liby, Tiera, Jaffe, Jacob D., Alimova, Maria, Davison, Desiree, Lu, Xiaodong, Golub, Todd R., Subramanian, Aravind, Shelley, Brandon, Svendsen, Clive N., Ma’ayan, Avi, Medvedovic, Mario, Feiler, Heidi S., Smith, Rebecca, Devlin, Kaylyn, Gray, Joe W., Birtwistle, Marc R., Heiser, Laura M., Sorger, Peter K.

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Paired evaluation of machine-learning models characterizes effects of confounders and outliers von Nariya, Maulik K., Mills, Caitlin E., Sorger, Peter K., Sokolov, Artem

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The Relative Biological Effectiveness of Low-Dose Mammography Quality X Rays in the Human Breast MCF-10A Cell Line von Mills, Caitlin E., Thome, Christopher, Koff, David, Andrews, David W., Boreham, Douglas R.

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A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses von Gross, Sean M., Dane, Mark A., Smith, Rebecca L., Devlin, Kaylyn L., McLean, Ian C., Derrick, Daniel S., Mills, Caitlin E., Subramanian, Kartik, London, Alexandra B., Torre, Denis, Evangelista, John Erol, Clarke, Daniel J. B., Xie, Zhuorui, Erdem, Cemal, Lyons, Nicholas, Natoli, Ted, Pessa, Sarah, Lu, Xiaodong, Mullahoo, James, Li, Jonathan, Adam, Miriam, Wassie, Brook, Liu, Moqing, Kilburn, David F., Liby, Tiera A., Bucher, Elmar, Sanchez-Aguila, Crystal, Daily, Kenneth, Omberg, Larsson, Wang, Yunguan, Jacobson, Connor, Yapp, Clarence, Chung, Mirra, Vidovic, Dusica, Lu, Yiling, Schurer, Stephan, Lee, Albert, Pillai, Ajay, Subramanian, Aravind, Papanastasiou, Malvina, Fraenkel, Ernest, Feiler, Heidi S., Mills, Gordon B., Jaffe, Jake D., Ma’ayan, Avi, Birtwistle, Marc R., Sorger, Peter K., Korkola, James E., Gray, Joe W., Heiser, Laura M.

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Development of CDK2 and CDK5 Dual Degrader TMX‐2172 von Teng, Mingxing, Jiang, Jie, He, Zhixiang, Kwiatkowski, Nicholas P., Donovan, Katherine A., Mills, Caitlin E., Victor, Chiara, Hatcher, John M., Fischer, Eric S., Sorger, Peter K., Zhang, Tinghu, Gray, Nathanael S.

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Targeting TBK1 to overcome resistance to cancer immunotherapy von Sun, Yi, Revach, Or-yam, Anderson, Seth, Kessler, Emily A., Wolfe, Clara H., Jenney, Anne, Mills, Caitlin E., Robitschek, Emily J., Davis, Thomas G. R., Kim, Sarah, Fu, Amina, Ma, Xiang, Gwee, Jia, Tiwari, Payal, Du, Peter P., Sindurakar, Princy, Tian, Jun, Mehta, Arnav, Schneider, Alexis M., Yizhak, Keren, Sade-Feldman, Moshe, LaSalle, Thomas, Sharova, Tatyana, Xie, Hongyan, Liu, Shuming, Michaud, William A., Saad-Beretta, Rodrigo, Yates, Kathleen B., Iracheta-Vellve, Arvin, Spetz, Johan K. E., Qin, Xingping, Sarosiek, Kristopher A., Zhang, Gao, Kim, Jong Wook, Su, Mack Y., Cicerchia, Angelina M., Rasmussen, Martin Q., Klempner, Samuel J., Juric, Dejan, Pai, Sara I., Miller, David M., Giobbie-Hurder, Anita, Chen, Jonathan H., Pelka, Karin, Frederick, Dennie T., Stinson, Susanna, Ivanova, Elena, Aref, Amir R., Paweletz, Cloud P., Barbie, David A., Sen, Debattama R., Fisher, David E., Corcoran, Ryan B., Hacohen, Nir, Sorger, Peter K., Flaherty, Keith T., Boland, Genevieve M., Manguso, Robert T., Jenkins, Russell W.

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The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations von Keenan, Alexandra B., Jenkins, Sherry L., Jagodnik, Kathleen M., Koplev, Simon, He, Edward, Torre, Denis, Wang, Zichen, Dohlman, Anders B., Silverstein, Moshe C., Kuleshov, Maxim V., Ma'ayan, Avi, Stathias, Vasileios, Terryn, Raymond, Cooper, Daniel, Forlin, Michele, Koleti, Amar, Vidovic, Dusica, Chung, Caty, Schürer, Stephan C., Vasiliauskas, Jouzas, Pilarczyk, Marcin, Shamsaei, Behrouz, Ren, Yan, Niu, Wen, Clark, Nicholas A., White, Shana, Mahi, Naim, Kouril, Michal, Reichard, John F., Medvedovic, Mario, Meller, Jaroslaw, Koch, Rick J., Birtwistle, Marc R., Iyengar, Ravi, Sobie, Eric A., Azeloglu, Evren U., Kaye, Julia, Osterloh, Jeannette, Haston, Kelly, Kalra, Jaslin, Finkbiener, Steve, Li, Jonathan, Milani, Pamela, Adam, Miriam, Escalante-Chong, Renan, Sachs, Karen, Lenail, Alex, Ramamoorthy, Divya, Fraenkel, Ernest, Daigle, Gavin, Hussain, Uzma, Coye, Alyssa, Rothstein, Jeffrey, Sareen, Dhruv, Banuelos, Maria, Mandefro, Berhan, Ho, Ritchie, Svendsen, Clive N., Lim, Ryan G., Stocksdale, Jennifer, Thompson, Terri G., Wu, Jie, Thompson, Leslie M., Dardov, Victoria, Venkatraman, Vidya, Matlock, Andrea, Van Eyk, Jennifer E., Jaffe, Jacob D., Papanastasiou, Malvina, Subramanian, Aravind, Golub, Todd R., Erickson, Sean D., Fallahi-Sichani, Mohammad, Hafner, Marc, Gray, Nathanael S., Lin, Jia-Ren, Mills, Caitlin E., Muhlich, Jeremy L., Shamu, Caroline E., Williams, Elizabeth H., Wrobel, David, Sorger, Peter K., Heiser, Laura M., Gray, Joe W., Korkola, James E., Mills, Gordon B., LaBarge, Mark, Feiler, Heidi S., Dane, Mark A., Bucher, Elmar, Nederlof, Michel, Sudar, Damir, Gross, Sean, Kilburn, David F., Smith, Rebecca, Devlin, Kaylyn, Margolis, Ron, Derr, Leslie, Lee, Albert, Pillai, Ajay

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