Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling von Rahaman, Mizanur M, Nguyen, Anh T, Miller, Megan P, Hahn, Scott A, Sparacino-Watkins, Courtney, Jobbagy, Soma, Carew, Nolan T, Cantu-Medellin, Nadiezhda, Wood, Katherine C, Baty, Catherine J, Schopfer, Francisco J, Kelley, Eric E, Gladwin, Mark T, Martin, Emil, Straub, Adam C

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Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death von Carew, Nolan T, Schmidt, Heidi M, Yuan, Shuai, Galley, Joseph C, Hall, Robert, Altmann, Helene M, Hahn, Scott A, Miller, Megan P, Wood, Katherine C, Gabris, Bethann, Stapleton, Margaret C, Hartwick, Sean, Fazzari, Marco, Wu, Yijen L, Trebak, Mohamed, Kaufman, Brett A, McTiernan, Charles F, Schopfer, Francisco J, Navas, Placido, Thibodeau, Patrick H, McNamara, Dennis M, Salama, Guy, Straub, Adam C

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Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation von Durgin, Brittany G, Hahn, Scott A, Schmidt, Heidi M, Miller, Megan P, Hafeez, Neha, Mathar, Ilka, Freitag, Daniel, Sandner, Peter, Straub, Adam C

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Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation von Yuan, Shuai, Hahn, Scott A., Miller, Megan P., Sanker, Subramaniam, Calderon, Michael J., Sullivan, Mara, Dosunmu-Ogunbi, Atinuke M., Fazzari, Marco, Li, Yao, Reynolds, Michael, Wood, Katherine C., St Croix, Claudette M., Stolz, Donna, Cifuentes-Pagano, Eugenia, Navas, Placido, Shiva, Sruti, Schopfer, Francisco J., Pagano, Patrick J., Straub, Adam C.

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CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling von Bueno, Marta, Calyeca, Jazmin, Khaliullin, Timur, Miller, Megan P, Alvarez, Diana, Rosas, Lorena, Brands, Judith, Baker, Christian, Nasser, Amro, Shulkowski, Stephanie, Mathien, August, Uzoukwu, Nneoma, Sembrat, John, Mays, Brenton G, Fiedler, Kaitlin, Hahn, Scott A, Salvatore, Sonia R, Schopfer, Francisco J, Rojas, Mauricio, Sandner, Peter, Straub, Adam C, Mora, Ana L

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FoxO4 controls sGCβ transcription in vascular smooth muscle von Galley, Joseph C, Miller, Megan P, Sanker, Subramaniam, Liu, Mingjun, Sharina, Iraida, Martin, Emil, Gomez, Delphine, Straub, Adam C

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Identification and functional characterization of a novel arginine/ornithine transporter, a member of a cationic amino acid transporter subfamily in the Trypanosoma cruzi genome von Henriques, Cristina, Miller, Megan P, Catanho, Marcos, de Carvalho, Técia Maria Ulisses, Krieger, Marco Aurélio, Probst, Christian M, de Souza, Wanderley, Degrave, Wim, Amara, Susan Gaye

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Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor–forkhead box subclass O transcription factor signalling axis von Galley, Joseph C., Hahn, Scott A., Miller, Megan P., Durgin, Brittany G., Jackson, Edwin K., Stocker, Sean D., Straub, Adam C.

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Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression von Galley, Joseph C, Durgin, Brittany G, Miller, Megan P, Hahn, Scott A, Yuan, Shuai, Wood, Katherine C, Straub, Adam C

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Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction von Straub, Adam C, Butcher, Joshua T, Billaud, Marie, Mutchler, Stephanie M, Artamonov, Mykhaylo V, Nguyen, Anh T, Johnson, Tyler, Best, Angela K, Miller, Megan P, Palmer, Lisa A, Columbus, Linda, Somlyo, Avril V, Le, Thu H, Isakson, Brant E

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Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT 1 receptor-forkhead box subclass O transcription factor signalling axis von Galley, Joseph C, Hahn, Scott A, Miller, Megan P, Durgin, Brittany G, Jackson, Edwin K, Stocker, Sean D, Straub, Adam C

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Targeting Pulmonary Endothelial Hemoglobin a Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction von Alvarez, Roger A, Miller, Megan P, Hahn, Scott A, Galley, Joseph C, Bauer, Eileen, Bachman, Timothy, Hu, Jian, Sembrat, John, Goncharov, Dmitry, Mora, Ana L, Rojas, Mauricio, Goncharova, Elena, Straub, Adam C

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Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability von Rahaman, Md. Mizanur, Reinders, Fabio G., Koes, David, Nguyen, Anh T., Mutchler, Stephanie M., Sparacino-Watkins, Courtney, Alvarez, Roger A., Miller, Megan P., Cheng, Dongmei, Chen, Bill B., Jackson, Edwin K., Camacho, Carlos J., Straub, Adam C.

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Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction von Alvarez, Roger A, Miller, Megan P, Hahn, Scott A, Galley, Joseph C, Bauer, Eileen, Bachman, Timothy, Hu, Jian, Sembrat, John, Goncharov, Dmitry, Mora, Ana L, Rojas, Mauricio, Goncharova, Elena, Straub, Adam C

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Preclinical Development and Screening of a Quinone-Nitroalkene Molecule for Sickle Cell Anemia von Chowdhury, Fabliha A, Miller, Megan P, Wood, Katherine C, Sharma, Malini, Yuan, Shuai, Taiclet, Stefanie N, Sinchar, Derek J, Rochon, Elizabeth R, Schopfer, Francisco J, Freeman, Bruce A, Straub, Adam C

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Angiotensin II augments renal vascular smooth muscle sGC expression via an AT1R - FoxO transcription factor signaling axis von Galley, Joseph C., Hahn, Scott A., Miller, Megan P., Durgin, Brittany G., Jackson, Edwin K., Stocker, Sean D., Straub, Adam C.

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Abstract P146: Cytochrome B5 Reductase (CYB5R3) Function in Smooth Muscle Cells and Blood Pressure Regulation von Durgin, Brittany G, Hahn, Scott A, Miller, Megan P, Straub, Adam C

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Abstract 503: Smooth Muscle Cell Cytochrome B5 reductase < CYB5R3 > expression modulates vascular tone von Durgin, Brittany G, Hahn, Scott A, Miller, Megan P, Straub, Adam C

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Abstract 575: Loss of Function Variant in CYB5R3 Associates With Exacerbated Cardiac Hypertrophy in Mice von Carew, Nolan T, Hahn, Scott, Miller, Megan P, Wood, Kathrine, Thideau, Patrick H, Kaufman, Brett A, McNamara, Dennis M, Straub, Adam C

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Abstract 103: Cytochrome b5 Reductase 3 Regulates Myoglobin Redox State and Controls Cardiac Function von Carew, Nolan T, Altmann, Helene M, Galley, Joseph C, Hahn, Scott, Miller, Megan P, Shiva, Sruti, McNamara, Dennis, Straub, Adam C

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