Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR von Garcia-Maldonado, Efren, Huber, Andrew D., Chai, Sergio C., Nithianantham, Stanley, Li, Yongtao, Wu, Jing, Poudel, Shyaron, Miller, Darcie J., Seetharaman, Jayaraman, Chen, Taosheng

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Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism von Duda, David M., Olszewski, Jennifer L., Schuermann, Jonathan P., Kurinov, Igor, Miller, Darcie J., Nourse, Amanda, Alpi, Arno F., Schulman, Brenda A.

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Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases von Scott, Daniel C., Chittori, Sagar, Purser, Nicholas, King, Moeko T., Maiwald, Samuel A., Churion, Kelly, Nourse, Amanda, Lee, Chan, Paulo, Joao A., Miller, Darcie J., Elledge, Stephen J., Harper, J. Wade, Kleiger, Gary, Schulman, Brenda A.

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Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes von Monda, Julie K., Scott, Daniel C., Miller, Darcie J., Lydeard, John, King, David, Harper, J. Wade, Bennett, Eric J., Schulman, Brenda A.

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Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2 von Scott, Daniel C., Dharuman, Suresh, Griffith, Elizabeth, Chai, Sergio C., Ronnebaum, Jarrid, King, Moeko T., Tangallapally, Rajendra, Lee, Chan, Gee, Clifford T., Yang, Lei, Li, Yong, Loudon, Victoria C., Lee, Ha Won, Ochoada, Jason, Miller, Darcie J., Jayasinghe, Thilina, Paulo, Joao A., Elledge, Stephen J., Harper, J. Wade, Chen, Taosheng, Lee, Richard E., Schulman, Brenda A.

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Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1 von Dove, Katja K., Olszewski, Jennifer L., Martino, Luigi, Duda, David M., Wu, Xiaoli S., Miller, Darcie J., Reiter, Katherine H., Rittinger, Katrin, Schulman, Brenda A., Klevit, Rachel E.

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Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases von Yang, Seung Wook, Huang, Xin, Lin, Wenwei, Min, Jaeki, Miller, Darcie J., Mayasundari, Anand, Rodrigues, Patrick, Griffith, Elizabeth C., Gee, Clifford T., Li, Lei, Li, Wei, Lee, Richard E., Rankovic, Zoran, Chen, Taosheng, Potts, Patrick Ryan

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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 von Kamadurai, Hari B, Qiu, Yu, Deng, Alan, Harrison, Joseph S, Macdonald, Chris, Actis, Marcelo, Rodrigues, Patrick, Miller, Darcie J, Souphron, Judith, Lewis, Steven M, Kurinov, Igor, Fujii, Naoaki, Hammel, Michal, Piper, Robert, Kuhlman, Brian, Schulman, Brenda A

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Structural basis for the transcriptional regulation of membrane lipid homeostasis von Miller, Darcie J, Zhang, Yong-Mei, Subramanian, Chitra, Rock, Charles O, White, Stephen W

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Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family von Broussard, Tyler C., Miller, Darcie J., Jackson, Pamela, Nourse, Amanda, White, Stephen W., Rock, Charles O.

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Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains von Minasov, George, Padavattan, Sivaraman, Shuvalova, Ludmilla, Brunzelle, Joseph S., Miller, Darcie J., Baslé, Arnaud, Massa, Claudia, Collart, Frank R., Schirmer, Tilman, Anderson, Wayne F.

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PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network von Huber, Andrew D., Lin, Wenwei, Poudel, Shyaron, Miller, Darcie J., Chen, Taosheng

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How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic von Regni, Catherine A, Roush, Rebecca F, Miller, Darcie J, Nourse, Amanda, Walsh, Christopher T, Schulman, Brenda A

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Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways von Wang, Jing, Taherbhoy, Asad M, Hunt, Harold W, Seyedin, Steven N, Miller, David W, Miller, Darcie J, Huang, Danny T, Schulman, Brenda A

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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein von Lin, Wenwei, Huber, Andrew D, Poudel, Shyaron, Li, Yongtao, Seetharaman, Jayaraman, Miller, Darcie J, Chen, Taosheng

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Mechanism for the activation of the anaplastic lymphoma kinase receptor von Reshetnyak, Andrey V., Rossi, Paolo, Myasnikov, Alexander G., Sowaileh, Munia, Mohanty, Jyotidarsini, Nourse, Amanda, Miller, Darcie J., Lax, Irit, Schlessinger, Joseph, Kalodimos, Charalampos G.

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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand von Huber, Andrew D, Poudel, Shyaron, Li, Yongtao, Lin, Wenwei, Wu, Jing, Miller, Darcie J, Chen, Taosheng

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Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases von Miller, Darcie J., Jerga, Agoston, Rock, Charles O., White, Stephen W.

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Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii von Radka, Christopher D., Miller, Darcie J., Frank, Matthew W., Rock, Charles O.

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases von Zhuang, Min, Calabrese, Matthew F., Liu, Jiang, Waddell, M. Brett, Nourse, Amanda, Hammel, Michal, Miller, Darcie J., Walden, Helen, Duda, David M., Seyedin, Steven N., Hoggard, Timothy, Harper, J. Wade, White, Kevin P., Schulman, Brenda A.

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