Model‐Informed Drug Development of the Masked Anti‑PD‑L1 Antibody CX‐072 von Stroh, Mark, Green, Michelle, Millard, Bjorn L., Apgar, Joshua F., Burke, John M., Garner, Will, Lu, Hong, Lyman, Susan K., Desnoyers, Luc R., Richardson, Jennifer, Hannah, Alison, Kavanaugh, W. Michael

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Adaptive informatics for multifactorial and high-content biological data von Millard, Bjorn L, Niepel, Mario, Menden, Michael P, Muhlich, Jeremy L, Sorger, Peter K

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Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody von Stroh, Mark, Sagert, Jason, Burke, John M., Apgar, Joshua F., Lin, Lin, Millard, Bjorn L., Michael Kavanaugh, W.

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Quantitative systems toxicology von Bloomingdale, Peter, Housand, Conrad, Apgar, Joshua F., Millard, Bjorn L., Mager, Donald E., Burke, John M., Shah, Dhaval K.

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Autocrine signaling is a key regulatory element during osteoclastogenesis von Kopesky, Paul, Tiedemann, Kerstin, Alkekhia, Dahlia, Zechner, Christoph, Millard, Bjorn, Schoeberl, Birgit, Komarova, Svetlana V

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Abstract 855: Model-informed drug design (MIDD) exploration of a theoretical CD47xTAA bispecific antibody using available data from magrolimab, an anti-CD47 monoclonal antibody von Pace, Emily A., Millard, Bjorn L.

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Abstract 4126: Inferring target occupancy from fitting nonlinear-PK data with mechanistic PKRO model for Pembrolizumab von Hua, Fei, Lin, Lin, Gruenbaum, Lore, Millard, Bjorn L., Burke, John M., Apgar, Joshua F.

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Preliminary population pharmacokinetics supports phase II dose selection for masked anti-PD-L1 antibody CX-072 von Stroh, Mark, Green, Michelle, Millard, Bjorn L., Garner, William, Lu, Hong, Richardson, Jennifer Hope, Hannah, Alison L.

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Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1 von Apgar, Joshua F., Tang, Jian‐Ping, Singh, Pratap, Balasubramanian, Nanda, Burke, John, Hodges, Michael R., Lasaro, Melissa A., Lin, Lin, Miliard, Bjorn L., Moore, Kristi, Jun, Lucy S., Sobolov, Susan, Wilkins, Anna Katharina, Gao, Xiang

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Preliminary single-dose clinical pharmacokinetics of an anti–PD-L1 Probody therapeutic (Pb-Tx) in cancer patients von Stroh, Mark, Serwer, Laura, Lu, Hong, Huels, Vanessa, Wong, Chihunt, Zheng, Beiyao, Millard, Bjorn L., Apgar, Joshua F., Zheng, Nancy, Richardson, Jennifer Hope, Will, Matthias, Humphrey, Rachel W.

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Abstract 413: Engineering Targeted Growth Factors for Selective Pro-survival Signaling in Apoptotic Cardiomyocytes Following Ischemic Injury von Stowe, Timothy R, Jennings-Antipov, Laura D, Kuchenbecker, Kristopher M, Zhang, Yan, Eshghi, Shawdee, Millard, Bjorn L, Nickerson, Andrea D, Nielsen, Ulrik B, Onsum, Matthew D

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Flexible informatics for linking experimental data to mathematical models via DataRail von Saez-Rodriguez, Julio, Goldsipe, Arthur, Muhlich, Jeremy, Alexopoulos, Leonidas G., Millard, Bjorn, Lauffenburger, Douglas A., Sorger, Peter K.

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Adaptive informatics for multi-factorial and high content biological data von Millard, Bjorn L, Niepel, Mario, Menden, Michael P, Muhlich, Jeremy L, Sorger, Peter K

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Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57 Kip2 von Worster, Devin T., Schmelzle, Tobias, Solimini, Nicole L., Lightcap, Eric S., Millard, Bjorn, Mills, Gordon B., Brugge, Joan S., Albeck, John G.

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Abstract 19086: Reducing Infarct Size by Protection of Ischemic Myocardium With Targeted Growth Factors von Chang, Henry H, Zhang, Yan, Stowe, Timothy R, Kuchenbecker, Kristopher M, Millard, Bjorn L, Nickerson, Andrea D, Schoeberl, Birgit M, Nielson, Ulrik B

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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2 von Worster, Devin T, Schmelzle, Tobias, Solimini, Nicole L, Lightcap, Eric S, Millard, Bjorn, Mills, Gordon B, Brugge, Joan S, Albeck, John G

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Method of treating skin tissue damage by topically administering a bi-specific protein comprising a human insulin-like growth factor variant and a human annexin A5 variant von Onsum, Matthew D, Eshghi, Shawdee, Stowe, Timothy R, Kuchenbecker, Kristopher M, Millard, Bjorn L, Antipov, Laura D. J, Nickerson, Andrea D, Zhang, Yan

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Bi-specific therapeutic proteins, in vivo methods of use thereof and encoding nucleic acids thereof von Onsum, Matthew D, Eshghi, Shawdee, Stowe, Timothy R, Kuchenbecker, Kristopher M, Millard, Bjorn L, Antipov, Laura D. J, Nickerson, Andrea D, Zhang, Yan

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METHODS OF TREATING SKIN TISSUE DAMAGE von Onsum, Matthew D, Eshghi, Shawdee, Stowe, Timothy R, Antipov, Laura D.J, Kuchenbecker, Kristopher M, Millard, Bjorn L, Nickerson, Andrea D, Zhang, Yan

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BI-SPECIFIC THERAPEUTIC PROTEINS AND METHOD OF USE THEREOF von Onsum, Matthew D, Eshghi, Shawdee, Stowe, Timothy R, Antipov, Laura D.J, Kuchenbecker, Kristopher M, Millard, Bjorn L, Nickerson, Andrea D, Zhang, Yan

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