Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924 von BLANK, Jonathan L, LIU, Xiaozhen J, MILHOLLEN, Michael A, LIGHTCAP, Eric S, COSMOPOULOS, Katherine, BOUCK, David C, GARCIA, Khristofer, BERNARD, Hugues, TAYBER, Olga, HATHER, Greg, LIU, Ray, NARAYANAN, Usha

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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 von Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

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NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells von Lin, Jie Jessie, Milhollen, Michael A, Smith, Peter G, Narayanan, Usha, Dutta, Anindya

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment von Hyer, Marc L, Milhollen, Michael A, Ciavarri, Jeff, Fleming, Paul, Traore, Tary, Sappal, Darshan, Huck, Jessica, Shi, Judy, Gavin, James, Brownell, Jim, Yang, Yu, Stringer, Bradley, Griffin, Robert, Bruzzese, Frank, Soucy, Teresa, Duffy, Jennifer, Rabino, Claudia, Riceberg, Jessica, Hoar, Kara, Lublinsky, Anya, Menon, Saurabh, Sintchak, Michael, Bump, Nancy, Pulukuri, Sai M, Langston, Steve, Tirrell, Stephen, Kuranda, Mike, Veiby, Petter, Newcomb, John, Li, Ping, Wu, Jing Tao, Powe, Josh, Dick, Lawrence R, Greenspan, Paul, Galvin, Katherine, Manfredi, Mark, Claiborne, Chris, Amidon, Benjamin S, Bence, Neil F

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Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover von Milhollen, Michael A, Narayanan, Usha, Soucy, Teresa A, Veiby, Petter O, Smith, Peter G, Amidon, Benjamin

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Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-Å resolution von Malashkevich, V N, Schneider, B J, McNally, M L, Milhollen, M A, Pang, J X, Kim, P S

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Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ von Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy von Soucy, Teresa A, Dick, Lawrence R, Smith, Peter G, Milhollen, Michael A, Brownell, James E

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Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924 von Jazaeri, Amir A, Shibata, Etsuko, Park, Jonghoon, Bryant, Jennifer L, Conaway, Mark R, Modesitt, Susan C, Smith, Peter G, Milhollen, Michael A, Berger, Allison J, Dutta, Anindya

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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues von Chen, Jesse J., Tsu, Christopher A., Gavin, James M., Milhollen, Michael A., Bruzzese, Frank J., Mallender, William D., Sintchak, Michael D., Bump, Nancy J., Yang, Xiaofeng, Ma, Jingya, Loke, Huay-Keng, Xu, Qing, Li, Ping, Bence, Neil F., Brownell, James E., Dick, Lawrence R.

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Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiat... von Milhollen, Michael A., Shi, Judy Qiuju, Traore, Tary, Huck, Jessica, Sappal, Darshan, Iwai, Kenichi, Ohashi, Akihiro, Rabino, Claudia, Duffy, Jennifer A., Lightcap, Eric, Ishii, Yuko, Ciavarri, Jeffrey, Bence, Neil, Berger, Allison J., Hyer, Marc L.

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Identification of D-Peptide Ligands Through Mirror-Image Phage Display von Ton N. M. Schumacher, Mayr, Lorenz M., Minor, Daniel L., Milhollen, Michael A., Burgess, Michael W., Kim, Peter S.

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma von Milhollen, Michael A., Traore, Tary, Adams-Duffy, Jennifer, Thomas, Michael P., Berger, Allison J., Dang, Lenny, Dick, Lawrence R., Garnsey, James J., Koenig, Erik, Langston, Steven P., Manfredi, Mark, Narayanan, Usha, Rolfe, Mark, Staudt, Louis M., Soucy, Teresa A., Yu, Jie, Zhang, Julie, Bolen, Joseph B., Smith, Peter G.

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Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and d... von Milhollen, Michael A., Shi, Judi, Traore, Tary, Huck, Jessica, Sappal, Darshan, Duffy, Jennifer, Lightcap, Eric, Ishii, Yuko, Ciavarri, Jeff, Fleming, Paul, Bence, Neil, Hyer, Marc L.

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Identification and Application of NEDD8 E1 Inhibitors von Bruzzese, Frank J., Milhollen, Michael A., Gavin, James M., Josephine, Helen R., Brownell, James E.

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Inhibition of NEDDB-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover von MILHOLLEN, Michael A, NARAYANAN, Usha, SOUCY, Teresa A, VEIBY, Petter O, SMITH, Peter G, AMIDON, Benjamin

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NEDD8 targeting drug MLN4924 elicits DNA re-replication by stabilizing Cdt1 in S Phase, triggering checkpoint activation, apoptosis and senescence in cancer cells von Lin, Jie Jessie, Milhollen, Michael A., Smith, Peter G., Narayanan, Usha, Dutta, Anindya

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Abstract C28: Treatment emergent mutations in NAEbeta confer resistance to the investigational NEDD8-activating enzyme inhibitor MLN4924 von Smith, Peter G., Thomas, Michael, Traore, Tary, Narayanan, Usha, Riceberg, Jessica, Amidon, Ben, Bence, Neil, Brownell, James, Dick, Larry, Manfredi, Mark, Sells, Todd, Sintchak, Mike, Koenig, Erik, Gavin, James, Milhollen, Michael A.

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma von Milhollen, Michael A, Traore, Tary, Adams-Duffy, Jennifer, Thomas, Michael P, Berger, Allison J, Dang, Lenny, Dick, Lawrence R, Garnsey, James J, Koenig, Erik, Langston, Steven P, Manfredi, Mark, Narayanan, Usha, Rolfe, Mark, Staudt, Louis M, Soucy, Teresa A, Yu, Jie, Zhang, Julie, Bolen, Joseph B, Smith, Peter G

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α-Lactalbumin forms a compact molten globule in the absence of disulfide bonds von Redfield, Christina, Schulman, Brenda A., Milhollen, Michael A., Kim, Peter S., Dobson, Christopher M.

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