Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models von Wang, Zebin, Sun, Kaiming, Xiao, Yonghong, Feng, Bin, Mikule, Keith, Ma, XiaoYan, Feng, Ningping, Vellano, Christopher P., Federico, Lorenzo, Marszalek, Joseph R., Mills, Gordon B., Hanke, Jeffrey, Ramaswamy, Sridhar, Wang, Jing

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Suppression of cancer relapse and metastasis by inhibiting cancer stemness von Li, Youzhi, Rogoff, Harry A., Keates, Sarah, Gao, Yuan, Murikipudi, Sylaja, Mikule, Keith, Leggett, David, Li, Wei, Pardee, Arthur B., Li, Chiang J.

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Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer von Carey, Jason P W, Karakas, Cansu, Bui, Tuyen, Chen, Xian, Vijayaraghavan, Smruthi, Zhao, Yang, Wang, Jing, Mikule, Keith, Litton, Jennifer K, Hunt, Kelly K, Keyomarsi, Khandan

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A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models von Sun, Kaiming, Mikule, Keith, Wang, Zebin, Poon, Grace, Vaidyanathan, Aparajitha, Smith, Gillian, Zhang, Zhi-Yi, Hanke, Jeffrey, Ramaswamy, Sridhar, Wang, Jing

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Abstract B168: The PARP inhibitor, niraparib, crosses the blood brain barrier in rodents and is efficacious in a BRCA2-mutant intracranial tumor model von Mikule, Keith, Wilcoxen, Keith

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Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1 von Wu, Jiaquan, Mikule, Keith, Wang, Wenxian, Su, Nancy, Petteruti, Philip, Gharahdaghi, Farzin, Code, Erin, Zhu, Xiahui, Jacques, Kelly, Lai, Zhongwu, Yang, Bin, Lamb, Michelle L, Chuaqui, Claudio, Keen, Nicholas, Chen, Huawei

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Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening von Yang, Bin, Lamb, Michelle L, Zhang, Tao, Hennessy, Edward J, Grewal, Gurmit, Sha, Li, Zambrowski, Mark, Block, Michael H, Dowling, James E, Su, Nancy, Wu, Jiaquan, Deegan, Tracy, Mikule, Keith, Wang, Wenxian, Kaspera, Rüdiger, Chuaqui, Claudio, Chen, Huawei

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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering von Gu, Chungang, Lamb, Michelle L., Johannes, Jeffrey W., Sylvester, Mark A., Eisman, Mark S., Harrison, Rane A., Hu, Haiqing, Kazmirski, Steven, Mikule, Keith, Peng, Bo, Su, Nancy, Wang, Wenxian, Ye, Qing, Zheng, Xiaolan, Lyne, Paul D., Scott, David A.

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Centrosome control of the cell cycle von Doxsey, Stephen, Zimmerman, Wendy, Mikule, Keith

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Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest von Delaval, Benedicte, Kaldis, Philipp, Hergert, Polla, Jurcyzk, Agata, Doxsey, Stephen, Mikule, Keith

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Growth Cone Collapse Induced by Semaphorin 3A Requires 12/15-Lipoxygenase von Mikule, Keith, Gatlin, Jesse C, de la Houssaye, Becky A, Pfenninger, Karl H

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Selective Induction of Necrotic Cell Death in Cancer Cells by β-Lapachone through Activation of DNA Damage Response Pathway von Sun, Xiangao, Li, Youzhi, Li, Wei, Zhang, Bin, Wang, A.J., Sun, Jieti, Mikule, Keith, Jiang, Zhiwei, Li, Chiang J.

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The IKK Inhibitor BMS-345541 Affects Multiple Mitotic Cell Cycle Transitions von Blazkova, Hana, von Schubert, Conrad, Mikule, Keith, Schwab, Rebekka, Angliker, Nico, Schmuckli-Maurer, Jacqueline, Fernandez, Paula C., Doxsey, Stephen, Dobbelaere, Dirk A.

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Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts von Póti, Ádám, Berta, Kinga, Xiao, Yonghong, Pipek, Orsolya, Klus, Gregory T., Ried, Thomas, Csabai, István, Wilcoxen, Keith, Mikule, Keith, Szallasi, Zoltan, Szüts, Dávid

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Abstract 1724: Evaluation of niraparib in combination with anti-PD1/anti-PD-L1 in preclinical models von Wang, Sarah, Sun, Kaiming, Xiao, Yonghong, Feng, Bin, Mikule, Keith, Ramaswamy, Sridhar, Hanke, Jeffrey, Wang, Jing

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Abstract B013: Elevation of immune cell infiltration and interferon-stimulated gene expression is associated with niraparib treatment in murine syngeneic tumor models von Wang, Sarah, Sun, Kaiming, Xiao, Yonghong, Mikule, Keith, Ramaswamy, Sridhar, Hanke, Jeffrey, Wang, Jing Yu

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Abstract 5690: Characterization of tumor growth and immune microenvironment in humanized NOG-EXL mice implanted with A549, MDA-MB-436 and A375 cells von Ghosh, Srimoyee, Fiore, Anne, Eberle, Christoph, Wang, Sarah, Mikule, Keith, McEachern, Kristen, Kumar, Sujatha, Jenkins, David, Sharma, Geeta

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme von Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T

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Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer von Wang, Zebin, Grosskurth, Shaun E, Cheung, Tony, Petteruti, Philip, Zhang, Jingwen, Wang, Xin, Wang, Wenxian, Gharahdaghi, Farzin, Wu, Jiaquan, Su, Nancy, Howard, Ryan T, Mayo, Michele, Widzowski, Dan, Scott, David A, Johannes, Jeffrey W, Lamb, Michelle L, Lawson, Deborah, Dry, Jonathan R, Lyne, Paul D, Tate, Edward W, Zinda, Michael, Mikule, Keith, Fawell, Stephen E, Reimer, Corinne, Chen, Huawei

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Abstract 4353: Preclinical evaluation of the PARP inhibitor niraparib and cytotoxic chemotherapy alone or in combination in a panel of 25 triple-negative breast cancer PDX models:... von Deas, Olivier, Cairo, Stefano, Wilcoxen, Keith, Mikule, Keith, Tran, Truong-An, Timms, Kirsten, Judde, Jean-Gabriel

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