Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors von Chen, Yan, Zhu, Jin-Yi, Hong, Kwon Ho, Mikles, David C, Georg, Gunda I, Goldstein, Alex S, Amory, John K, Schönbrunn, Ernst

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Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling von Jiang, Xiaoyu, Lu, Xiaoqing, Zhang, Yu, Lacaria, Leda, Schuchardt, Brett J., Mikles, David C., Magistri, Marco, García-Ramírez, Idoia, Sanchez-Garcia, Isidro, Farooq, Amjad, Verdun, Ramiro E., Abdulreda, Midhat H., Moy, Vincent T., Lossos, Izidore S.

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General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases von Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido

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Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors von Goel, Parul, Jumpertz, Thorsten, Tichá, Anežka, Ogorek, Isabella, Mikles, David C., Hubalek, Martin, Pietrzik, Claus U., Strisovsky, Kvido, Schmidt, Boris, Weggen, Sascha

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Discovery and Biological Evaluation of Potent and Selective N‑Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases von Goel, Parul, Jumpertz, Thorsten, Mikles, David C, Tichá, Anežka, Nguyen, Minh T. N, Verhelst, Steven, Hubalek, Martin, Johnson, Darren C, Bachovchin, Daniel A, Ogorek, Isabella, Pietrzik, Claus U, Strisovsky, Kvido, Schmidt, Boris, Weggen, Sascha

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Molecular Origin of the Binding of WWOX Tumor Suppressor to ErbB4 Receptor Tyrosine Kinase von Schuchardt, Brett J, Bhat, Vikas, Mikles, David C, McDonald, Caleb B, Sudol, Marius, Farooq, Amjad

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Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase von Schuchardt, Brett J., Bhat, Vikas, Mikles, David C., McDonald, Caleb B., Sudol, Marius, Farooq, Amjad

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Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity von Schuchardt, Brett J, Mikles, David C, Hoang, Lawrence M, Bhat, Vikas, McDonald, Caleb B, Sudol, Marius, Farooq, Amjad

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Biophysical Basis of the Binding of WWOX Tumor Suppressor to WBP1 and WBP2 Adaptors von McDonald, Caleb B., Buffa, Laura, Bar-Mag, Tomer, Salah, Zaidoun, Bhat, Vikas, Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Malhotra, Arun, Sudol, Marius, Aqeilan, Rami I., Nawaz, Zafar, Farooq, Amjad

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Effect of osmolytes on the binding of EGR1 transcription factor to DNA von Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., McDonald, Caleb B., Farooq, Amjad

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pH modulates the binding of early growth response protein 1 transcription factor to DNA von Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., Deegan, Brian J., Seldeen, Kenneth L., McDonald, Caleb B., Farooq, Amjad

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Biophysical Analysis of Binding of WW Domains of the YAP2 Transcriptional Regulator to PPXY Motifs within WBP1 and WBP2 Adaptors von McDonald, Caleb B, McIntosh, Samantha K. N, Mikles, David C, Bhat, Vikas, Deegan, Brian J, Seldeen, Kenneth L, Saeed, Ali M, Buffa, Laura, Sudol, Marius, Nawaz, Zafar, Farooq, Amjad

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Role of promoter DNA sequence variations on the binding of EGR1 transcription factor von Mikles, David C., Schuchardt, Brett J., Bhat, Vikas, McDonald, Caleb B., Farooq, Amjad

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Molecular determinants of the binding specificity of BH3 ligands to BclXL apoptotic repressor von Bhat, Vikas, Olenick, Max B., Schuchardt, Brett J., Mikles, David C., McDonald, Caleb B., Farooq, Amjad

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Bivalent binding drives the formation of the Grb2–Gab1 signaling complex in a noncooperative manner von McDonald, Caleb B., Bhat, Vikas, Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Farooq, Amjad

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Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch von Schuchardt, Brett J., Mikles, David C., Bhat, Vikas, McDonald, Caleb B., Sudol, Marius, Farooq, Amjad

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Biophysical basis of the promiscuous binding of B-cell lymphoma protein 2 apoptotic repressor to BH3 ligands von Bhat, Vikas, Olenick, Max B., Schuchardt, Brett J., Mikles, David C., McDonald, Caleb B., Farooq, Amjad

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Ligand Binding and Membrane Insertion Compete with Oligomerization of the BclXL Apoptotic Repressor von Bhat, Vikas, McDonald, Caleb B., Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Bates, Margaret L., Farooq, Amjad

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Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA von Seldeen, Kenneth L, Deegan, Brian J, Bhat, Vikas, Mikles, David C, McDonald, Caleb B, Farooq, Amjad

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Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2–Sos1 Signaling Complex in a Cooperative Manner von McDonald, Caleb B, Balke, Jordan E, Bhat, Vikas, Mikles, David C, Deegan, Brian J, Seldeen, Kenneth L, Farooq, Amjad

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