CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL von Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.

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Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets von Sehgal, Kartik, Das, Rituparna, Zhang, Lin, Verma, Rakesh, Deng, Yanhong, Kocoglu, Mehmet, Vasquez, Juan, Koduru, Srinivas, Ren, Yan, Wang, Maria, Couto, Suzana, Breider, Mike, Hansel, Donna, Seropian, Stuart, Cooper, Dennis, Thakurta, Anjan, Yao, Xiaopan, Dhodapkar, Kavita M., Dhodapkar, Madhav V.

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Discovery of Highly Potent and Selective Pan-Aurora Kinase Inhibitors with Enhanced in Vivo Antitumor Therapeutic Index von Liu, Gang, Abraham, Sunny, Tran, Lan, Vickers, Troy D, Xu, Shimin, Hadd, Michael J, Quiambao, Sheena, Holladay, Mark W, Hua, Helen, Ford Pulido, Julia M, Gunawardane, Ruwanthi N, Davis, Mindy I, Eichelberger, Shawn R, Apuy, Julius L, Gitnick, Dana, Gardner, Michael F, James, Joyce, Breider, Mike A, Belli, Barbara, Armstrong, Robert C, Treiber, Daniel K

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Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases von Liu, Gang, Campbell, Brian T, Holladay, Mark W, Ford Pulido, Julia M, Hua, Helen, Gitnick, Dana, Gardner, Michael F, James, Joyce, Breider, Mike A, Brigham, Daniel, Belli, Barbara, Armstrong, Robert C, Treiber, Daniel K

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Abstract 5445: Dual-color immunohistochemistry assays for measuring Aiolos and Ikaros proteins in multiple myeloma patient samples von Ren, Yan, Wang, Maria, Couto, Suzana, Hansel, Donna, Gandhi, Anita K., Hagner, Patrick, Thakurta, Anjan, Chopra, Rajesh, Breider, Mike

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Abstract 1354: Comparison of pomalidomide dosing strategies in lenalidomide-refractory myeloma: Impact on clinical outcome, immune activation and cereblon targets von Das, Rituparna, Sehgal, Kartik, Zhang, Lin, Verma, Rakesh, Deng, Yanhong, Kocoglu, Mehmet, Vasquez, Juan, Koduru, Srini, Ren, Yan, Wang, Maria, Couto, Suzana, Breider, Mike, Hansel, Donna, Seropian, Stuart, Cooper, Dennis, Thakurta, Anjan, Yao, Xiaopan, Dhodapkar, Kavita M., Dhodapkar, Madhav V.

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Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds von Bjorklund, Chad C, Havens, Courtney G., Hagner, Patrick R, Gandhi, Anita K., Wang, Maria, Amatangelo, Michael D, Lu, Ling, Wang, Huisheng, Breider, Mike, Ren, Yan, Lopez-Girona, Antonia, Thakurta, Anjan, Klippel, Anke, Chopra, Rajesh

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CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways von Hagner, Patrick, Wang, Maria, Couto, Suzana, Breider, Mike, Fontanillo, Celia, Trotter, Matthew, Bjorklund, Chad C, Havens, Courtney G., Raymon, Heather K, Narla, Rama Krishna, Barnes, Leo, Waldman, Michelle, Daniel, Tom, Klippel, Anke, Pourdehnad, Michael, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.

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Retinal Degeneration in Rats Induced by CI-1010, a 2-Nitroimidazole Radiosensitizer von Breider, Mike A., Pilcher, Gary D., Graziano, Michael J., Gough, Alex W.

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Tumor cell-enhanced sensitivity of vascular endothelial cells to photodynamic therapy von Yang, Zhengang, Lu, Xiaochen, Frazier, Donita L., Panjehpour, Masoud, Breider, Mike A.

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METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS von GANDHI, ANITA, KLIPPEL, ANKE, HAGNER, PATRICK, BREIDER, MIKE, HOLLENBACH, PAUL, TROTTER, MATTHEW WILLIAM BURNELL, COUTO, SUZANA STURLINI, HAVENS, COURTNEY G, CHOPRA, RAJESH, MACBETH, KYLE, WANG, MARIA YINGLIN, REN, YAN

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Nitro-Imidazole Radiosensitizer-Induced Toxicity in Cynomolgus Monkeys von Breider, Mike A., Ulloa, Herm M., Pegg, David G., Gough, Alex W.

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METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS von WANG, Maria Yinglin, CHOPRA, Rajesh, TROTTER, Matthew William Burnell, KLIPPEL, Anke, HOLLENBACH, Paul, COUTO, Suzana Sturlini, BREIDER, Mike, MACBETH, Kyle, HAVENS, Courtney G, REN, Yan, HAGNER, Patrick, GANDHI, Anita

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METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS von WANG, Maria, Yinglin, TROTTER, Matthew William, Burnell, COUTO, Suzana, Sturlini, CHOPRA, Rajesh, KLIPPEL, Anke, HOLLENBACH, Paul, BREIDER, Mike, MACBETH, Kyle, HAVENS, Courtney, G, REN, Yan, HAGNER, Patrick, GANDHI, Anita

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Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers von Trotter, Matthew William Burnell, Wang, Maria Yinglin, Klippel, Anke, Gandhi, Anita, Ren, Yan, Breider, Mike, Hollenbach, Paul, Havens, Courtney G, Macbeth, Kyle, Chopra, Rajesh, Hagner, Patrick, Couto, Suzana Sturlini

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Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers von Trotter, Matthew William Burnell, Wang, Maria Yinglin, Klippel, Anke, Gandhi, Anita, Ren, Yan, Breider, Mike, Hollenbach, Paul, Havens, Courtney G, Macbeth, Kyle, Chopra, Rajesh, Hagner, Patrick, Couto, Suzana Sturlini

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Alveolar Macrophage and Neutrophil Interactions in Pasteurella haemolytica-Induced Endothelial Cell Injury von Sharma, Smita A., Olchowy, T. W.J., Breider, Mike A.

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METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS von WANG, Maria Yinglin, CHOPRA, Rajesh, TROTTER, Matthew William Burnell, KLIPPEL, Anke, HOLLENBACH, Paul, COUTO, Suzana Sturlini, BREIDER, Mike, MACBETH, Kyle, HAVENS, Courtney G, REN, Yan, HAGNER, Patrick, GANDHI, Anita

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Métodos para determinar la eficacia del fármaco para el tratamiento de linfoma difuso de células B grandes, mieloma múltiple y cánceres mieloides von COUTO, Suzana, HAVENS, Courtney, CHOPRA, Rajesh, TROTTER, Matthew William, KLIPPEL, Anke, HOLLENBACH, Paul, BREIDER, Mike, MACBETH, Kyle, REN, Yan, HAGNER, Patrick, GANDHI, Anita, WANG, Maria

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Cytokine modulation of endothelial cell sensitivity to photodynamic therapy von Breider, Mike A., Lu, Xiaochen, Panjehpour, Masoud, Frazier, Donita L.

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