Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development von Kamerzell, Tim J., Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.

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Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release von Jiskoot, Wim, Randolph, Theodore W., Volkin, David B., Russell Middaugh, C., Schöneich, Christian, Winter, Gerhard, Friess, Wolfgang, Crommelin, Daan J.A., Carpenter, John F.

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The Effect of Small Oligomeric Protein Aggregates on the Immunogenicity of Intravenous and Subcutaneous Administered Antibodies von Fathallah, Anas M., Chiang, Manting, Mishra, Anshul, Kumar, Sandeep, Xue, Li, Russell Middaugh, C., Balu-Iyer, Sathy V.

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Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies von Kumru, Ozan S., Joshi, Sangeeta B., Smith, Dawn E., Middaugh, C. Russell, Prusik, Ted, Volkin, David B.

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High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability von Chaudhuri, Rajoshi, Cheng, Yuan, Middaugh, C. Russell, Volkin, David B.

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Formulation and stabilization of recombinant protein based virus-like particle vaccines von Jain, Nishant K., Sahni, Neha, Kumru, Ozan S., Joshi, Sangeeta B., Volkin, David B., Russell Middaugh, C.

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Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody von Kalonia, Cavan, Toprani, Vishal, Toth, Ronald, Wahome, Newton, Gabel, Ian, Middaugh, C. Russell, Volkin, David B

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Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality von Carpenter, John F., Randolph, Theodore W., Jiskoot, Wim, Crommelin, Daan J.A., Russell Middaugh, C., Winter, Gerhard, Fan, Ying-Xin, Kirshner, Susan, Verthelyi, Daniela, Kozlowski, Steven, Clouse, Kathleen A., Swann, Patrick G., Rosenberg, Amy, Cherney, Barry

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Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice... von Xiao, Yuhong, Zeng, Yuhong, Schante, Carole, Joshi, Sangeeta B., Buchman, George W., Volkin, David B., Middaugh, C. Russell, Isaacs, Stuart N.

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Permeation of the three aromatic dipeptides through lipid bilayers: Experimental and computational study von Lee, Brent L., Kuczera, Krzysztof, Middaugh, C. Russell, Jas, Gouri S.

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The Complex Inter-Relationships Between Protein Flexibility and Stability von Kamerzell, Tim J., Russell Middaugh, C.

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Effect of Ionic Strength and pH on the Physical and Chemical Stability of a Monoclonal Antibody Antigen-Binding Fragment von Wang, Tingting, Kumru, Ozan S., Yi, Li, John Wang, Y., Zhang, Jennifer, Kim, Jae Hyun, Joshi, Sangeeta B., Russell Middaugh, C., Volkin, David B.

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Formulation Design and High-Throughput Excipient Selection Based on Structural Integrity and Conformational Stability of Dilute and Highly Concentrated IgG1 Monoclonal Antibody Sol... von Bhambhani, Akhilesh, Kissmann, Julian M., Joshi, Sangeeta B., Volkin, David B., Kashi, Ramesh S., Russell Middaugh, C.

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Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions von Telikepalli, Srivalli N., Kumru, Ozan S., Kalonia, Cavan, Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.

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Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity von Arora, Jayant, Hu, Yue, Esfandiary, Reza, Sathish, Hasige A, Bishop, Steven M, Joshi, Sangeeta B, Middaugh, C Russell, Volkin, David B, Weis, David D

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Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1 von Hu, Yue, Arora, Jayant, Joshi, Sangeeta B., Esfandiary, Reza, Middaugh, C. Russell, Weis, David D., Volkin, David B.

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Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists von Zacharia, Athina, Harberts, Erin, Valencia, Sarah M., Myers, Breana, Sanders, Chelsea, Jain, Akshay, Larson, Nicholas R., Middaugh, C. Russell, Picking, William D., Difilippantonio, Simone, Kirnbauer, Reinhard, Roden, Richard B., Pinto, Ligia A., Shoemaker, Robert H., Ernst, Robert K., Marshall, Jason D.

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Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody von Majumdar, Ranajoy, Manikwar, Prakash, Hickey, John M, Samra, Hardeep S, Sathish, Hasige A, Bishop, Steven M, Middaugh, C. Russell, Volkin, David B, Weis, David D

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Multidimensional methods for the formulation of biopharmaceuticals and vaccines von Maddux, Nathaniel R., Joshi, Sangeeta B., Volkin, David B., Ralston, John P., Middaugh, C. Russell

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Identification of properties important to protein aggregation using feature selection von Fang, Yaping, Gao, Shan, Tai, David, Middaugh, C Russell, Fang, Jianwen

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