SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice von Banks, Alexander S., Kon, Ning, Knight, Colette, Matsumoto, Michihiro, Gutiérrez-Juárez, Roger, Rossetti, Luciano, Gu, Wei, Accili, Domenico

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The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice von Inaba, Yuka, Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Oshima, Yu, Tsuchiya, Kohsuke, Murai, Shin, Takahashi, Chiaki, Matsumoto, Michihiro, Kitajima, Shigetaka, Yamamoto, Yasuhiko, Honda, Masao, Asahara, Shun-ichiro, Ravnskjaer, Kim, Horike, Shin-ichi, Kaneko, Shuichi, Kasuga, Masato, Nakano, Hiroyasu, Harada, Kenichi, Inoue, Hiroshi

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Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice von Inaba, Yuka, Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Sato, Makoto, Kobayashi, Masaki, Matsumoto, Michihiro, Kitamura, Tadahiro, Kasuga, Masato, Inoue, Hiroshi

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Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure von Iwata, Wakiko, Unoki-Kubota, Hiroyuki, Kato, Hideki, Shimizu, Akira, Matsumoto, Michihiro, Imasawa, Toshiyuki, Igarashi, Arisa, Matsumoto, Kenji, Noda, Tetsuo, Terauchi, Yasuo, Nangaku, Masaomi, Kasuga, Masato, Kaburagi, Yasushi

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Diet intake control is indispensable for the gluconeogenic response to sodium–glucose cotransporter 2 inhibition in male mice von Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Matsumoto, Michihiro, Inoue, Hiroshi, Inaba, Yuka

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Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution von Tsukasaki, Masayuki, Huynh, Nam Cong-Nhat, Okamoto, Kazuo, Muro, Ryunosuke, Terashima, Asuka, Kurikawa, Yoshitaka, Komatsu, Noriko, Pluemsakunthai, Warunee, Nitta, Takeshi, Abe, Takaya, Kiyonari, Hiroshi, Okamura, Tadashi, Sakai, Mashito, Matsukawa, Toshiya, Matsumoto, Michihiro, Kobayashi, Yasuhiro, Penninger, Josef M., Takayanagi, Hiroshi

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A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism von Cook, Joshua R, Matsumoto, Michihiro, Banks, Alexander S, Kitamura, Tadahiro, Tsuchiya, Kyoichiro, Accili, Domenico

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The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch von Sakai, Mashito, Tujimura-Hayakawa, Tomoko, Yagi, Takashi, Yano, Hiroyuki, Mitsushima, Masaru, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Inoue, Hiroshi, Kido, Yoshiaki, Kasuga, Masato, Matsumoto, Michihiro

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Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c von Asahara, Shun-ichiro, Etoh, Hiroaki, Inoue, Hiroyuki, Teruyama, Kyoko, Shibutani, Yuki, Ihara, Yuka, Kawada, Yukina, Bartolome, Alberto, Hashimoto, Naoko, Matsuda, Tomokazu, Koyanagi-Kimura, Maki, Kanno, Ayumi, Hirota, Yushi, Hosooka, Tetsuya, Nagashima, Kazuaki, Nishimura, Wataru, Inoue, Hiroshi, Matsumoto, Michihiro, Higgins, Michael J, Yasuda, Kazuki, Inagaki, Nobuya, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki

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Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation von KIMURA, Kumi, YAMADA, Tomoko, MIYAMOTO, Kenichi, KANEKO, Shuichi, KASUGA, Masato, INOUE, Hiroshi, MATSUMOTO, Michihiro, KIDO, Yoshiaki, HOSOOKA, Tetsuya, ASAHARA, Shun-Ichiro, MATSUDA, Tomokazu, OTA, Tsuguhito, WATANABE, Hiroshi, SAI, Yoshimichi

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Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway von Chao, Hsu-Wen, Doi, Masao, Fustin, Jean-Michel, Chen, Huatao, Murase, Kimihiko, Maeda, Yuki, Hayashi, Hida, Tanaka, Rina, Sugawa, Maho, Mizukuchi, Naoki, Yamaguchi, Yoshiaki, Yasunaga, Jun-ichirou, Matsuoka, Masao, Sakai, Mashito, Matsumoto, Michihiro, Hamada, Shinshichi, Okamura, Hitoshi

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Role of hepatic STAT3 in brain-insulin action on hepatic glucose production von Inoue, Hiroshi, Ogawa, Wataru, Asakawa, Akihiro, Okamoto, Yasuo, Nishizawa, Akihiko, Matsumoto, Michihiro, Teshigawara, Kiyoshi, Matsuki, Yasushi, Watanabe, Eijiro, Hiramatsu, Ryuji, Notohara, Kenji, Katayose, Koji, Okamura, Hitoshi, Kahn, C. Ronald, Noda, Tetsuo, Takeda, Kiyoshi, Akira, Shizuo, Inui, Akio, Kasuga, Masato

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Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells von Tanaka, Jun, Qiang, Li, Banks, Alexander S, Welch, Carrie L, Matsumoto, Michihiro, Kitamura, Tadahiro, Ido-Kitamura, Yukari, DePinho, Ronald A, Accili, Domenico

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Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo von Kasuga, Masato, Inoue, Hiroshi, Ogawa, Wataru, Ozaki, Michitaka, Haga, Sanae, Matsumoto, Michihiro, Furukawa, Kensuke, Hashimoto, Naoko, Kido, Yoshiaki, Mori, Toshiyuki, Sakaue, Hiroshi, Teshigawara, Kiyoshi, Jin, Shiyu, Iguchi, Haruhisa, Hiramatsu, Ryuji, LeRoith, Derek, Takeda, Kiyoshi, Akira, Shizuo

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Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 von Koyanagi, Maki, Asahara, Shun-ichiro, Matsuda, Tomokazu, Hashimoto, Naoko, Shigeyama, Yutaka, Shibutani, Yuki, Kanno, Ayumi, Fuchita, Megumi, Mikami, Tomoko, Hosooka, Tetsutya, Inoue, Hiroshi, Matsumoto, Michihiro, Koike, Masato, Uchiyama, Yasuo, Noda, Tetsuo, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki

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Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models von Matsukawa, Toshiya, Yagi, Takashi, Uchida, Tohru, Sakai, Mashito, Mitsushima, Masaru, Naganuma, Takao, Yano, Hiroyuki, Inaba, Yuka, Inoue, Hiroshi, Yanagida, Keisuke, Uematsu, Masaaki, Nakao, Kazuki, Nakao, Harumi, Aiba, Atsu, Nagashima, Yoji, Kubota, Tetsuya, Kubota, Naoto, Izumida, Yoshihiko, Yahagi, Naoya, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Asahara, Shun-Ichiro, Kido, Yoshiaki, Shindou, Hideo, Itoh, Michiko, Ogawa, Yoshihiro, Minami, Shiro, Terauchi, Yasuo, Tobe, Kazuyuki, Ueki, Kohjiro, Kasuga, Masato, Matsumoto, Michihiro

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Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced... von Nagare, Tomoki, Sakaue, Hiroshi, Matsumoto, Michihiro, Cao, Yongheng, Inagaki, Kenjiro, Sakai, Mashito, Takashima, Yasuhiro, Nakamura, Kyoko, Mori, Toshiyuki, Okada, Yuko, Matsuki, Yasushi, Watanabe, Eijiro, Ikeda, Kazutaka, Taguchi, Ryo, Kamimura, Naomi, Ohta, Shigeo, Hiramatsu, Ryuji, Kasuga, Masato

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Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes von Kotani, Ko, Ogawa, Wataru, Matsumoto, Michihiro, Kitamura, Tadahiro, Sakaue, Hiroshi, Hino, Yasuhisa, Miyake, Kazuaki, Sano, Wataru, Akimoto, Kazunori, Ohno, Shigeo, Kasuga, Masato

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InsP3R-Ca(2+) signaling takes center stage in the hormonal regulation of hepatic gluconeogenesis von Matsumoto, Michihiro

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Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Gluco... von MATSUMOTO, Michihiro, OGAWA, Wataru, TESHIGAWARA, Kiyoshi, INOUE, Hiroshi, MIYAKE, Kazuaki, SAKAUE, Hiroshi, KASUGA, Masato

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