The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia von Shivanna, Sowmya, Kolandaivelu, Kumaran, Shashar, Moshe, Belghasim, Mostafa, Al-Rabadi, Laith, Balcells, Mercedes, Zhang, Anqi, Weinberg, Janice, Francis, Jean, Pollastri, Michael P, Edelman, Elazer R, Sherr, David H, Chitalia, Vipul C

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Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production von Lowe, Margaret M, Mold, Jeff E, Kanwar, Bittoo, Huang, Yong, Louie, Alexander, Pollastri, Michael P, Wang, Cuihua, Patel, Gautam, Franks, Diana G, Schlezinger, Jennifer, Sherr, David H, Silverstone, Allen E, Hahn, Mark E, McCune, Joseph M

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The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target von Kunz, Stefan, Balmer, Vreni, Sterk, Geert Jan, Pollastri, Michael P, Leurs, Rob, Müller, Norbert, Hemphill, Andrew, Spycher, Cornelia

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Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon von Pollastri, Michael P.

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Finding new collaboration models for enabling neglected tropical disease drug discovery von Pollastri, Michael P

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Anilinoquinoline based inhibitors of trypanosomatid proliferation von Ferrins, Lori, Sharma, Amrita, Thomas, Sarah M, Mehta, Naimee, Erath, Jessey, Tanghe, Scott, Leed, Susan E, Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J, Gillingwater, Kirsten, Pollastri, Michael P

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Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign von Diaz, Rosario, Luengo-Arratta, Sandra A, Seixas, João D, Amata, Emanuele, Devine, William, Cordon-Obras, Carlos, Rojas-Barros, Domingo I, Jimenez, Elena, Ortega, Fatima, Crouch, Sabrinia, Colmenarejo, Gonzalo, Fiandor, Jose Maria, Martin, Jose Julio, Berlanga, Manuela, Gonzalez, Silvia, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P

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The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing von Diaz-Gonzalez, Rosario, Kuhlmann, F Matthew, Galan-Rodriguez, Cristina, Madeira da Silva, Luciana, Saldivia, Manuel, Karver, Caitlin E, Rodriguez, Ana, Beverley, Stephen M, Navarro, Miguel, Pollastri, Michael P

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Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents von Klug, Dana M, Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Gomez-Pérez, Veronica, Ruiz-Pérez, Luis Miguel, Rojas-Barros, Domingo I, Gamarro, Francisco, González-Pacanowska, Dolores, Martínez-Martínez, María S, Manzano, Pilar, Ferrins, Lori, Caffrey, Conor R, Navarro, Miguel, Pollastri, Michael P

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Repurposing strategies for tropical disease drug discovery von Klug, Dana M., Gelb, Michael H., Pollastri, Michael P.

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A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes von Galvin, Brendan D, Li, Zhiru, Villemaine, Estelle, Poole, Catherine B, Chapman, Melissa S, Pollastri, Michael P, Wyatt, Paul G, Carlow, Clotilde K S

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Application of l‑Threonine Aldolase to on-DNA Reactions von Chai, Jing, Lu, Xiaojie, Arico-Muendel, Christopher C, Ding, Yun, Pollastri, Michael P

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Synthesis of a DNA-Encoded Macrocyclic Library Utilizing Intramolecular Benzimidazole Formation von Chai, Jing, Arico-Muendel, Christopher C., Ding, Yun, Pollastri, Michael P., Scott, Sarah, Mantell, Mark A., Yao, Gang

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Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1) von Amata, Emanuele, Bland, Nicholas D., Campbell, Robert K., Pollastri, Michael P.

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Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development von Sanz-Rodríguez, Carlos E., Hoffman, Benjamin, Guyett, Paul J., Purmal, Andrei, Singh, Baljinder, Pollastri, Michael P., Mensa-Wilmot, Kojo

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Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites von Merritt, Christopher, Silva, Lisseth E., Tanner, Angela L., Stuart, Kenneth, Pollastri, Michael P.

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Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery von Singh, Baljinder, Sharma, Amrita, Gunaganti, Naresh, Rivers, Mitch, Gadekar, Pradip K., Greene, Brady, Chichioco, Michael, Sanz-Rodriguez, Carlos E., Fu, Courtney, LeBlanc, Catherine, Burchfield, Erin, Sharif, Nyle, Hoffman, Benjamin, Kumar, Gaurav, Purmal, Andrei, Mensa-Wilmot, Kojo, Pollastri, Michael P.

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Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum von Absalon, Sabrina, Blomqvist, Karin, Rudlaff, Rachel M, DeLano, Travis J, Pollastri, Michael P, Dvorin, Jeffrey D

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Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors von Singh, Baljinder, Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, Rojas-Barros, Domingo I, Gunaganti, Naresh, Gillingwater, Kirsten, Martinez-Martinez, Maria Santos, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P

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Pharmacophore Identification and Structure–Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of Trypanosoma brucei von Ferrins, Lori, Diaz, Rosario, Cordon-Obras, Carlos, Rojas-Barros, Domingo, Quotadamo, Antonio, Oehme, Daniel P., Ceballos-Pérez, Gloria, Swaminathan, Uma, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, García-Hernández, Raquel, Gomez-Liñan, Claudia, Saura, Andreu, Ruiz-Perez, Luis Miguel, Gamarro, Francisco, Martinez-Martinez, Maria Santos, Manzano, Pilar, González-Pacanowska, Dolores, Navarro, Miguel, Pollastri, Michael P.

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