Drugs for bad bugs: confronting the challenges of antibacterial discovery von Pompliano, David L, Payne, David J, Gwynn, Michael N, Holmes, David J

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Challenges of antibacterial discovery revisited von Gwynn, Michael N., Portnoy, Alison, Rittenhouse, Stephen F., Payne, David J.

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Type IIA topoisomerase inhibition by a new class of antibacterial agents von Giordano, Ilaria, Spitzfaden, Claus E, Jones, Emma, Theobald, Andrew J, Gorrec, Fabrice, Jones, Jo, Hann, Michael M, May, Earl W, Saunders, Martin R, Fosberry, Andrew, Chan, Pan F, Eggleston, Drake S, Hibbs, Martin, Brown, Kristin Koretke, Lewis, Ceri J, Bax, Benjamin D, Singh, Onkar, Pearson, Neil D, Wohlkonig, Alexandre, Hennessy, Alan, Gentry, Daniel R, Huang, Jianzhong, Shen, Carol, Gwynn, Michael N, Shillings, Anthony

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Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance von Gwynn, Michael N, Bax, Benjamin D, Wohlkonig, Alexandre, Chan, Pan F, Fosberry, Andrew P, Homes, Paul, Huang, Jianzhong, Kranz, Michael, Leydon, Vaughan R, Miles, Timothy J, Pearson, Neil D, Perera, Rajika L, Shillings, Anthony J

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Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus von GENTRY, Daniel R, MCCLOSKEY, Lynn, GWYNN, Michael N, RITTENHOUSE, Stephen F, SCANGARELLA, Nicole, SHAWAR, Ribhi, HOLMES, David J

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Novel Chromosomally Encoded Multidrug Efflux Transporter MdeA in Staphylococcus aureus von Huang, Jianzhong, O'Toole, Paul W, Shen, Wei, Amrine-Madsen, Heather, Jiang, Xinhe, Lobo, Neethan, Palmer, Leslie M, Voelker, LeRoy, Fan, Frank, Gwynn, Michael N, McDevitt, Damien

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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin von Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D., Gwynn, Michael N.

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Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases von Miles, Timothy J., Hennessy, Alan J., Bax, Ben, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Jones, Graham E., Kusalakumari Sukmar, Senthill K., Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N., Pearson, Neil D.

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Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases von Miles, Timothy J., Hennessy, Alan J., Bax, Ben, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Huang, Jianzhong, Jones, Graham E., Kusalakumari Sukmar, Senthill K., Spitzfaden, Claus, Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N., Pearson, Neil D.

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Enterococcus faecalis Acetoacetyl-Coenzyme A Thiolase/3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, a Dual-Function Protein of Isopentenyl Diphosphate Biosynthesis von Hedl, Matija, Sutherlin, Autumn, Wilding, E Imogen, Mazzulla, Marie, McDevitt, Damien, Lane, Pamela, Burgner, 2nd, John W, Lehnbeuter, Kevin R, Stauffacher, Cynthia V, Gwynn, Michael N, Rodwell, Victor W

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Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases von Miles, Timothy J., Barfoot, Christopher, Brooks, Gerald, Brown, Pamela, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Downie, David L., Eyrisch, Susanne, Giordano, Ilaria, Gwynn, Michael N., Hennessy, Alan, Hoover, Jennifer, Huang, Jianzhong, Jones, Graham, Markwell, Roger, Rittenhouse, Stephen, Xiang, Hong, Pearson, Neil

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Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae, with Implications for Fluoroquinolone Resistanc... von STANHOPE, Michael J, WALSH, Stacey L, AMRINE-MADSEN, Heather, BECKER, Julie A, ITALIA, Michael J, INGRAHAM, Karen A, GWYNN, Michael N, MATHIE, Tom, POUPARD, James A, MILLER, Linda A, BROWN, James R

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Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases von Miles, Timothy J., Axten, Jeffrey M., Barfoot, Christopher, Brooks, Gerald, Brown, Pamela, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Downie, David L., Eyrisch, Susanne, Gallagher, Timothy, Giordano, Ilaria, Gwynn, Michael N., Hennessy, Alan, Hoover, Jennifer, Huang, Jianzhong, Jones, Graham, Markwell, Roger, Miller, William H., Minthorn, Elizabeth A., Rittenhouse, Stephen, Seefeld, Mark, Pearson, Neil

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A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential von Gentry, Daniel R., Wilding, Imogen, Johnson, John M., Chen, Dongzhao, Remlinger, Katja, Richards, Cindy, Neill, Susan, Zalacain, Magdalena, Rittenhouse, Stephen F., Gwynn, Michael N.

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Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci von Wilding, E I, Brown, J R, Bryant, A P, Chalker, A F, Holmes, D J, Ingraham, K A, Iordanescu, S, So, C Y, Rosenberg, M, Gwynn, M N

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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide von Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.

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Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism von Campobasso, Nino, Patel, Mehul, Wilding, Imogen E, Kallender, Howard, Rosenberg, Martin, Gwynn, Michael N

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Susceptibility of Pseudomonas aeruginosa to catechol-substituted cephalosporin is unrelated to the pyochelin-Fe transporter FptA von Hoegy, Françoise, Gwynn, Michael N, Schalk, Isabelle J

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Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus von Wilding, E I, Kim, D Y, Bryant, A P, Gwynn, M N, Lunsford, R D, McDevitt, D, Myers, Jr, J E, Rosenberg, M, Sylvester, D, Stauffacher, C V, Rodwell, V W

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Staphylococcus aureus gyrase-quinolone-DNA ternary complexes fail to arrest replication fork progression in vitro. Effects of salt on the DNA binding mode and the catalytic activit... von Hiasa, Hiroshi, Shea, Molly E, Richardson, Christine M, Gwynn, Michael N

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