PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells von Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.

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The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis von Dominy, John E., Lee, Yoonjin, Jedrychowski, Mark P., Chim, Helen, Jurczak, Michael J., Camporez, Joao Paulo, Ruan, Hai-Bin, Feldman, Jessica, Pierce, Kerry, Mostoslavsky, Raul, Denu, John M., Clish, Clary B., Yang, Xiaoyong, Shulman, Gerald I., Gygi, Steven P., Puigserver, Pere

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Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes von Perry, Rachel J., Camporez, João-Paulo G., Kursawe, Romy, Titchenell, Paul M., Zhang, Dongyan, Perry, Curtis J., Jurczak, Michael J., Abudukadier, Abulizi, Han, Myoung Sook, Zhang, Xian-Man, Ruan, Hai-Bin, Yang, Xiaoyong, Caprio, Sonia, Kaech, Susan M., Sul, Hei Sook, Birnbaum, Morris J., Davis, Roger J., Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I.

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Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch von Cohen, Paul, Levy, Julia D., Zhang, Yingying, Frontini, Andrea, Kolodin, Dmitriy P., Svensson, Katrin J., Lo, James C., Zeng, Xing, Ye, Li, Khandekar, Melin J., Wu, Jun, Gunawardana, Subhadra C., Banks, Alexander S., Camporez, João Paulo G., Jurczak, Michael J., Kajimura, Shingo, Piston, David W., Mathis, Diane, Cinti, Saverio, Shulman, Gerald I., Seale, Patrick, Spiegelman, Bruce M.

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase von Madiraju, Anila K., Erion, Derek M., Rahimi, Yasmeen, Zhang, Xian-Man, Braddock, Demetrios T., Albright, Ronald A., Prigaro, Brett J., Wood, John L., Bhanot, Sanjay, MacDonald, Michael J., Jurczak, Michael J., Camporez, Joao-Paulo, Lee, Hui-Young, Cline, Gary W., Samuel, Varman T., Kibbey, Richard G., Shulman, Gerald I.

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Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis von Weisel, Florian J., Mullett, Steven J., Elsner, Rebecca A., Menk, Ashley V., Trivedi, Nikita, Luo, Wei, Wikenheiser, Daniel, Hawse, William F., Chikina, Maria, Smita, Shuchi, Conter, Laura J., Joachim, Stephen M., Wendell, Stacy G., Jurczak, Michael J., Winkler, Thomas H., Delgoffe, Greg M., Shlomchik, Mark J.

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A Metabolic Basis for Endothelial-to-Mesenchymal Transition von Xiong, Jianhua, Kawagishi, Hiroyuki, Yan, Ye, Liu, Jie, Wells, Quinn S., Edmunds, Lia R., Fergusson, Maria M., Yu, Zu-Xi, Rovira, Ilsa I., Brittain, Evan L., Wolfgang, Michael J., Jurczak, Michael J., Fessel, Joshua P., Finkel, Toren

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Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance von Petersen, Max C, Madiraju, Anila K, Gassaway, Brandon M, Marcel, Michael, Nasiri, Ali R, Butrico, Gina, Marcucci, Melissa J, Zhang, Dongyan, Abulizi, Abudukadier, Zhang, Xian-Man, Philbrick, William, Hubbard, Stevan R, Jurczak, Michael J, Samuel, Varman T, Rinehart, Jesse, Shulman, Gerald I

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Assessment of Tissue-Specific Glucose Uptake: Teaching an Old 2-DOG New Tricks von Petersen, Max C, Jurczak, Michael J

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Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis von Argemi, Josepmaria, Latasa, Maria U., Atkinson, Stephen R., Blokhin, Ilya O., Massey, Veronica, Gue, Joel P., Cabezas, Joaquin, Lozano, Juan J., Van Booven, Derek, Bell, Aaron, Cao, Sheng, Vernetti, Lawrence A., Arab, Juan P., Ventura-Cots, Meritxell, Edmunds, Lia R., Fondevila, Constantino, Stärkel, Peter, Dubuquoy, Laurent, Louvet, Alexandre, Odena, Gemma, Gomez, Juan L., Aragon, Tomas, Altamirano, Jose, Caballeria, Juan, Jurczak, Michael J., Taylor, D. Lansing, Berasain, Carmen, Wahlestedt, Claes, Monga, Satdarshan P., Morgan, Marsha Y., Sancho-Bru, Pau, Mathurin, Philippe, Furuya, Shinji, Lackner, Carolin, Rusyn, Ivan, Shah, Vijay H., Thursz, Mark R., Mann, Jelena, Avila, Matias A., Bataller, Ramon

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Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice von Cao, Simon, Jurczak, Michael J, Shuda, Yoko, Sun, Rui, Shuda, Masahiro, Chang, Yuan, Moore, Patrick S

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Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice von Camporez, João-Paulo G., Petersen, Max C., Abudukadier, Abulizi, Moreira, Gabriela V., Jurczak, Michael J., Friedman, Glenn, Haqq, Christopher M., Petersen, Kitt Falk, Shulman, Gerald I.

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Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler von Perry, Rachel J., Kim, Taehan, Zhang, Xian-Man, Lee, Hui-Young, Pesta, Dominik, Popov, Violeta B., Zhang, Dongyan, Rahimi, Yasmeen, Jurczak, Michael J., Cline, Gary W., Spiegel, David A., Shulman, Gerald I.

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CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha von Kumamoto, Yosuke, Camporez, Joao Paulo G., Jurczak, Michael J., Shanabrough, Marya, Horvath, Tamas, Shulman, Gerald I., Iwasaki, Akiko

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The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology von DeVallance, Evan, Li, Yao, Jurczak, Michael J, Cifuentes-Pagano, Eugenia, Pagano, Patrick J

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Development of insulin resistance in mice lacking PGC-1α in adipose tissues von Kleiner, Sandra, Mepani, Rina J, Laznik, Dina, Ye, Li, Jurczak, Michael J, Jornayvaz, Francois R, Estall, Jennifer L, Chatterjee Bhowmick, Diti, Shulman, Gerald I, Spiegelman, Bruce M

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2039-LB: Insulin Sensitivity Is Impaired Independent of Changes in Body Weight in Liver-Specific GDF15 Knockout Mice von KASTROLL, JAKE, JURCZAK, MICHAEL J., ALDER, JONATHAN, VANDEVENDER, AMBER, DEDOUSIS, NIKOLAOS, SIPULA, IAN J.

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Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids von Vatner, Daniel F., Majumdar, Sachin K., Kumashiro, Naoki, Petersen, Max C., Rahimi, Yasmeen, Gattu, Arijeet K., Bears, Mitchell, Camporez, João-Paulo G., Cline, Gary W., Jurczak, Michael J., Samuel, Varman T., Shulman, Gerald I.

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Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia von Haslip, Maria, Dostanic, Iva, Huang, Yan, Zhang, Yi, Russell, Kerry S, Jurczak, Michael J, Mannam, Praveen, Giordano, Frank, Erzurum, Serpil C, Lee, Patty J

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity von Henao-Mejia, Jorge, Elinav, Eran, Jin, Chengcheng, Hao, Liming, Mehal, Wajahat Z., Strowig, Till, Thaiss, Christoph A., Kau, Andrew L., Eisenbarth, Stephanie C., Jurczak, Michael J., Camporez, Joao-Paulo, Shulman, Gerald I., Gordon, Jeffrey I., Hoffman, Hal M., Flavell, Richard A.

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