Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 von Mares, Alina, Miah, Afjal H., Smith, Ian E. D., Rackham, Mark, Thawani, Aditya R., Cryan, Jenni, Haile, Pamela A., Votta, Bartholomew J., Beal, Allison M., Capriotti, Carol, Reilly, Michael A., Fisher, Don T., Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T., Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B., Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D.

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Catalytic in vivo protein knockdown by small-molecule PROTACs von Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M

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HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins von Buckley, Dennis L, Raina, Kanak, Darricarrere, Nicole, Hines, John, Gustafson, Jeffrey L, Smith, Ian E, Miah, Afjal H, Harling, John D, Crews, Craig M

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Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach von Bassi, Zuni I, Fillmore, Martin C, Miah, Afjal H, Chapman, Trevor D, Maller, Claire, Roberts, Emma J, Davis, Lauren C, Lewis, Darcy E, Galwey, Nicholas W, Waddington, Kirsty E, Parravicini, Valentino, Macmillan-Jones, Abigail L, Gongora, Celine, Humphreys, Philip G, Churcher, Ian, Prinjha, Rab K, Tough, David F

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Optimization of a Series of RIPK2 PROTACs von Miah, Afjal H, Smith, Ian E. D, Rackham, Mark, Mares, Alina, Thawani, Aditya R, Nagilla, Rakesh, Haile, Pamela A, Votta, Bartholomew J, Gordon, Laurie J, Watt, Gillian, Denyer, Jane, Fisher, Don T, Dace, Phoebe, Giffen, Paul, Goncalves, Andrea, Churcher, Ian, Scott-Stevens, Paul, Harling, John D

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Innovative, combinatorial and high-throughput approaches to degrader synthesis von Stevens, Rebecca, Thompson, James D. F, Fournier, Julie C. L, Burley, Glenn A, Battersby, David J, Miah, Afjal H

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Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs von Stevens, Rebecca, Bendito-Moll, Enrique, Battersby, David J, Miah, Afjal H, Wellaway, Natalie, Law, Robert P, Stacey, Peter, Klimaszewska, Diana, Macina, Justyna M, Burley, Glenn A, Harling, John D

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A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions von Zalessky, Illya, Wootton, Jack M., Tam, Jerry K. F., Spurling, Dominic E., Glover-Humphreys, William C., Donald, James R., Orukotan, Will E., Duff, Lee C., Knapper, Ben J., Whitwood, Adrian C., Tanner, Theo F. N., Miah, Afjal H., Lynam, Jason M., Unsworth, William P.

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Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists von Miah, Afjal H., Champigny, Aurelie C., Graves, Rebecca H., Hodgson, Simon T., Percy, Jonathan M., Procopiou, Panayiotis A.

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Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists von Procopiou, Panayiotis A, Barrett, John W, Barton, Nicholas P, Begg, Malcolm, Clapham, David, Copley, Royston C. B, Ford, Alison J, Graves, Rebecca H, Hall, David A, Hancock, Ashley P, Hill, Alan P, Hobbs, Heather, Hodgson, Simon T, Jumeaux, Coline, Lacroix, Yannick M. L, Miah, Afjal H, Morriss, Karen M. L, Needham, Deborah, Sheriff, Emma B, Slack, Robert J, Smith, Claire E, Sollis, Steven L, Staton, Hugo

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2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis von Shukla, Lena, Ajram, Laura A., Begg, Malcolm, Evans, Brian, Graves, Rebecca H., Hodgson, Simon T., Lynn, Sean M., Miah, Afjal H., Percy, Jonathan M., Procopiou, Panayiotis A., Richards, Stephen A., Slack, Robert J.

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Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists von Miah, Afjal H, Copley, Royston C B, O'Flynn, Daniel, Percy, Jonathan M, Procopiou, Panayiotis A

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Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists von Miah, Afjal H., Abas, Hossay, Begg, Malcolm, Marsh, Benjamin J., O’Flynn, Daniel E., Ford, Alison J., Percy, Jonathan M., Procopiou, Panayiotis A., Richards, Steve A., Rumley, Sally-Anne

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Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonistsElectronic supplementary inf... von Miah, Afjal H, Copley, Royston C. B, O'Flynn, Daniel, Percy, Jonathan M, Procopiou, Panayiotis A

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A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions von Zalessky, Illya, Wootton, Jack M, Tam, Jerry K F, Spurling, Dominic E, Glover-Humphreys, William C, Donald, James R, Orukotan, Will E, Duff, Lee C, Knapper, Ben J, Whitwood, Adrian C, Tanner, Theo F N, Miah, Afjal H, Lynam, Jason M, Unsworth, William P

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COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE E3 von GAREISS PETER, C. PC, MIAH, AFJAL, HUSSAIN AH, VAN MOLLE, INGE I, ROTH, ANKE, G. AG, TAE, HYUN-SEOP H-S, CAMPOS, SEBASTIEN, ANDRE SA, MICHEL, JULIEN J, SMITH, IAN EDWARD, DAVID IED, BUCKLEY, DENNIS D, CIULLI, ALESSIO A, JORGENSEN, WILLIAM W, HARLING, JOHN, DAVID JD, GUSTAFSON, JEFFREY J, HOYER, DENTON, WADE DW, LE, JOELLE J, CREWS, CRAIG, M. CM

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A Potentially Divergent and Rapid Route to Analogues of Deoxycyclitols, Pentopyranoses, 6-Deoxyhexoses, and Hexoses von Audouard, Christophe, Fawcett, John, Griffith, Gerry A, Kérourédan, Erwan, Miah, Afjal, Percy, Jonathan M, Yang, Hongli

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