DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia von Metzeler, K H, Walker, A, Geyer, S, Garzon, R, Klisovic, R B, Bloomfield, C D, Blum, W, Marcucci, G

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Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism von Krupka, C, Kufer, P, Kischel, R, Zugmaier, G, Lichtenegger, F S, Köhnke, T, Vick, B, Jeremias, I, Metzeler, K H, Altmann, T, Schneider, S, Fiegl, M, Spiekermann, K, Bauerle, P A, Hiddemann, W, Riethmüller, G, Subklewe, M

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Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia von Sandhöfer, N, Metzeler, K H, Rothenberg, M, Herold, T, Tiedt, S, Groiß, V, Carlet, M, Walter, G, Hinrichsen, T, Wachter, O, Grunert, M, Schneider, S, Subklewe, M, Dufour, A, Fröhling, S, Klein, H-G, Hiddemann, W, Jeremias, I, Spiekermann, K

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Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers von Jahn, A., Rump, A., Widmann, T.J., Heining, C., Horak, P., Hutter, B., Paramasivam, N., Uhrig, S., Gieldon, L., Drukewitz, S., Kübler, A., Bermudez, M., Hackmann, K., Porrmann, J., Wagner, J., Arlt, M., Franke, M., Fischer, J., Kowalzyk, Z., William, D., Weth, V., Oster, S., Fröhlich, M., Hüllein, J., Valle González, C., Kreutzfeldt, S., Mock, A., Heilig, C.E., Lipka, D.B., Möhrmann, L., Hanf, D., Oleś, M., Teleanu, V., Allgäuer, M., Ruhnke, L., Kutz, O., Knurr, A., Laßmann, A., Endris, V., Neumann, O., Penzel, R., Beck, K., Richter, D., Winter, U., Wolf, S., Pfütze, K., Geörg, C., Meißburger, B., Buchhalter, I., Augustin, M., Aulitzky, W.E., Hohenberger, P., Kroiss, M., Schirmacher, P., Schlenk, R.F., Keilholz, U., Klauschen, F., Folprecht, G., Bauer, S., Siveke, J.T., Brandts, C.H., Kindler, T., Boerries, M., Illert, A.L., von Bubnoff, N., Jost, P.J., Metzeler, K.H., Bitzer, M., Schulze-Osthoff, K., von Kalle, C., Brors, B., Stenzinger, A., Weichert, W., Hübschmann, D., Fröhling, S., Glimm, H., Schröck, E., Klink, B.

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GAS6 expression identifies high-risk adult AML patients: potential implications for therapy von Whitman, S P, Kohlschmidt, J, Maharry, K, Volinia, S, Mrózek, K, Nicolet, D, Schwind, S, Becker, H, Metzeler, K H, Mendler, J H, Eisfeld, A-K, Carroll, A J, Powell, B L, Carter, T H, Baer, M R, Kolitz, J E, Park, I-K, Stone, R M, Caligiuri, M A, Marcucci, G, Bloomfield, C D

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An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia von Herold, T, Jurinovic, V, Metzeler, K H, Boulesteix, A-L, Bergmann, M, Seiler, T, Mulaw, M, Thoene, S, Dufour, A, Pasalic, Z, Schmidberger, M, Schmidt, M, Schneider, S, Kakadia, P M, Feuring-Buske, M, Braess, J, Spiekermann, K, Mansmann, U, Hiddemann, W, Buske, C, Bohlander, S K

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Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia von Niederwieser, C, Kohlschmidt, J, Volinia, S, Whitman, S P, Metzeler, K H, Eisfeld, A-K, Maharry, K, Yan, P, Frankhouser, D, Becker, H, Schwind, S, Carroll, A J, Nicolet, D, Mendler, J H, Curfman, J P, Wu, Y-Z, Baer, M R, Powell, B L, Kolitz, J E, Moore, J O, Carter, T H, Bundschuh, R, Larson, R A, Stone, R M, Mrózek, K, Marcucci, G, Bloomfield, C D

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A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid... von Metzeler, K H, Maharry, K, Kohlschmidt, J, Volinia, S, Mrózek, K, Becker, H, Nicolet, D, Whitman, S P, Mendler, J H, Schwind, S, Eisfeld, A-K, Wu, Y-Z, Powell, B L, Carter, T H, Wetzler, M, Kolitz, J E, Baer, M R, Carroll, A J, Stone, R M, Caligiuri, M A, Marcucci, G, Bloomfield, C D

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1979TiP - Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring dna repa... von Heilig, C.E., Hübschmann, D., Kopp, H.-G., Metzeler, K.H., Richter, S., Hermes, B., von Bubnoff, N., Kindler, T., Siveke, J., Wagner, S., Ochsenreither, S., Süße, H., Brors, B., Benner, A., Jäger, D., Von Kalle, C., Glimm, H., Gröschel, S., Fröhling, S., Schlenk, R.F.

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Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring dna repair deficie... von Heilig, C.E., Hübschmann, D., Kopp, H.-G., Metzeler, K.H., Richter, S., Hermes, B., von Bubnoff, N., Kindler, T., Siveke, J., Wagner, S., Ochsenreither, S., Süße, H., Brors, B., Benner, A., Jäger, D., Von Kalle, C., Glimm, H., Gröschel, S., Fröhling, S., Schlenk, R.F.

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Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8 von Becker, H, Maharry, K, Mrózek, K, Volinia, S, Eisfeld, A-K, Radmacher, M D, Kohlschmidt, J, Metzeler, K H, Schwind, S, Whitman, S P, Mendler, J H, Wu, Y-Z, Nicolet, D, Paschka, P, Powell, B L, Carter, T H, Wetzler, M, Kolitz, J E, Carroll, A J, Baer, M R, Caligiuri, M A, Stone, R M, Marcucci, G, Bloomfield, C D

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The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia von Thoene, S, Rawat, V P S, Heilmeier, B, Hoster, E, Metzeler, K H, Herold, T, Hiddemann, W, Gökbuget, N, Hoelzer, D, Bohlander, S K, Feuring-Buske, M, Buske, C

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The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia von Whitman, S P, Caligiuri, M A, Maharry, K, Radmacher, M D, Kohlschmidt, J, Becker, H, Mrózek, K, Wu, Y-Z, Schwind, S, Metzeler, K H, Mendler, J H, Wen, J, Baer, M R, Powell, B L, Carter, T H, Kolitz, J E, Wetzler, M, Carroll, A J, Larson, R A, Marcucci, G, Bloomfield, C D

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PS1058 NOVEL CIRCULATING TUMOR DNA (CTDNA) BASED DDPCR DROP‐OFF ASSAYS FOR IMPROVED DISEASE MONITORING IN ACUTE MYELOID LEUKEMIA (AML) A “LIQUID BIOPSY” FOR A “LIQUID TUMOR”... von Rausch, C., Ziemann, F., Schneider, S., Subklewe, M., Karsten, S., Rothenberg‐Thurley, M., Metzeler, K.H.

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PS1015 SINGLE‐CELL RNA‐SEQUENCING & GENOTYPING OF PATIENTS WITH WT1‐SUBCLONAL AML TO ELUCIDATE CLONAL HETEROGENEITY von Niggemeyer, J., Bagnoli, J.W., Wange, L., Rothenberg‐Thurley, M., Ziegenhain, C., Subklewe, M., Karsten, S., Enard, W., Metzeler, K.H.

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PF217 TARGETING FLT3 IN AML: MODULATION OF FLT3‐BITE® ACTIVITY THROUGH COMBINATION WITH VARIOUS TKI von Brauchle, B., Goldstein, R., Chi‐Ming, L., Buecklein, V., Krupka, C., Koppikar, P., Haubner, S., Thomas, O., Rock, D., Sastri, C., Cooke, K., Bergwelt‐Baildon, M., Metzeler, K.H., Spiekermann, K., Arvedson, T.L., Subklewe, M.

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