ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms von Wilson, Emma Louise, Metzakopian, Emmanouil

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Correction: ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms von Wilson, Emma Louise, Metzakopian, Emmanouil

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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks von Balmus, Gabriel, Pilger, Domenic, Coates, Julia, Demir, Mukerrem, Sczaniecka-Clift, Matylda, Barros, Ana C., Woods, Michael, Fu, Beiyuan, Yang, Fengtang, Chen, Elisabeth, Ostermaier, Matthias, Stankovic, Tatjana, Ponstingl, Hannes, Herzog, Mareike, Yusa, Kosuke, Martinez, Francisco Munoz, Durant, Stephen T., Galanty, Yaron, Beli, Petra, Adams, David J., Bradley, Allan, Metzakopian, Emmanouil, Forment, Josep V., Jackson, Stephen P.

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Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing von Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.

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Predicting the mutations generated by repair of Cas9-induced double-strand breaks von Allen, Felicity, Crepaldi, Luca, Alsinet, Clara, Strong, Alexander J., Kleshchevnikov, Vitalii, De Angeli, Pietro, Páleníková, Petra, Khodak, Anton, Kiselev, Vladimir, Kosicki, Michael, Bassett, Andrew R., Harding, Heather, Galanty, Yaron, Muñoz-Martínez, Francisco, Metzakopian, Emmanouil, Jackson, Stephen P., Parts, Leopold

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Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson’s disease patient-derived iPSCs von Patikas, Nikolaos, Ansari, Rizwan, Metzakopian, Emmanouil

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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia von Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke

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Single-Cell Transcriptomics of Parkinson’s Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses von Fernandes, Hugo J.R., Patikas, Nikolaos, Foskolou, Stefanie, Field, Sarah F., Park, Jong-Eun, Byrne, Meg L., Bassett, Andrew R., Metzakopian, Emmanouil

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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 von Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.

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MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development von Parada, Guillermo E, Munita, Roberto, Georgakopoulos-Soares, Ilias, Fernandes, Hugo J R, Kedlian, Veronika R, Metzakopian, Emmanouil, Andres, Maria Estela, Miska, Eric A, Hemberg, Martin

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Cholesterol determines the cytosolic entry and seeded aggregation of tau von Tuck, Benjamin J., Miller, Lauren V.C., Katsinelos, Taxiarchis, Smith, Annabel E., Wilson, Emma L., Keeling, Sophie, Cheng, Shi, Vaysburd, Marina J., Knox, Claire, Tredgett, Lucy, Metzakopian, Emmanouil, James, Leo C., McEwan, William A.

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Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution von Martirosyan, Araks, Ansari, Rizwan, Pestana, Francisco, Hebestreit, Katja, Gasparyan, Hayk, Aleksanyan, Razmik, Hnatova, Silvia, Poovathingal, Suresh, Marneffe, Catherine, Thal, Dietmar R, Kottick, Andrew, Hanson-Smith, Victor J, Guelfi, Sebastian, Plumbly, William, Belgard, T Grant, Metzakopian, Emmanouil, Holt, Matthew G

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CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death von Pavlou, Sofia, Foskolou, Stefanie, Patikas, Nikolaos, Field, Sarah F., Papachristou, Evangelia K., Santos, Clive D’, Edwards, Abigail R., Kishore, Kamal, Ansari, Rizwan, Rajan, Sandeep S., Fernandes, Hugo J. R., Metzakopian, Emmanouil

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Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming von Yang, Jian, Rajan, Sandeep S., Friedrich, Mathias J., Lan, Guocheng, Zou, Xiangang, Ponstingl, Hannes, Garyfallos, Dimitrios A., Liu, Pentao, Bradley, Allan, Metzakopian, Emmanouil

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Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages von Stott, Simon R W, Metzakopian, Emmanouil, Lin, Wei, Kaestner, Klaus H, Hen, Rene, Ang, Siew-Lan

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The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons von Tolve, Marianna, Ulusoy, Ayse, Patikas, Nikolaos, Islam, K. Ushna S., Bodea, Gabriela O., Öztürk, Ece, Broske, Bianca, Mentani, Astrid, Wagener, Antonia, van Loo, Karen M.J., Britsch, Stefan, Liu, Pengtao, Khaled, Walid T., Metzakopian, Emmanouil, Baader, Stephan L., Di Monte, Donato A., Blaess, Sandra

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Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing von Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.

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Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries von Metzakopian, Emmanouil, Strong, Alex, Iyer, Vivek, Hodgkins, Alex, Tzelepis, Konstantinos, Antunes, Liliana, Friedrich, Mathias J, Kang, Qiaohua, Davidson, Teresa, Lamberth, Jacob, Hoffmann, Christina, Davis, Gregory D., Vassiliou, George S., Skarnes, William C., Bradley, Allan

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Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective von Wilson, Emma L., Yu, Yizhou, Leal, Nuno S., Woodward, James A., Patikas, Nikolaos, Morris, Jordan L., Field, Sarah F., Plumbly, William, Paupe, Vincent, Chowdhury, Suvagata R., Antrobus, Robin, Lindop, Georgina E., Adia, Yusuf M., Loh, Samantha H. Y., Prudent, Julien, Martins, L. Miguel, Metzakopian, Emmanouil

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Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation von Chabrat, Audrey, Brisson, Guillaume, Doucet-Beaupré, Hélène, Salesse, Charleen, Schaan Profes, Marcos, Dovonou, Axelle, Akitegetse, Cléophace, Charest, Julien, Lemstra, Suzanne, Côté, Daniel, Pasterkamp, R. Jeroen, Abrudan, Monica I., Metzakopian, Emmanouil, Ang, Siew-Lan, Lévesque, Martin

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