Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors von Kerkhof, H J M, Bierma-Zeinstra, S M A, Arden, N K, Metrustry, S, Castano-Betancourt, M, Hart, D J, Hofman, A, Rivadeneira, F, Oei, E H G, Spector, Tim D, Uitterlinden, A G, Janssens, A C J W, Valdes, A M, van Meurs, J B J

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[OP.LB.02.07] BLOOD PRESSURE AND HEXADECANEDIOATE: DISSECTING FUNCTIONAL PATHWAYS von Menni, C, Metrustry, S, Ehret, G, Dominiczak, A.F, Chowienczyk, P, Spector, T.D, Padmanabhan, S, Valdes, A.M

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Novel susceptability loci for osteoarthritis of the hand: Coding variants in MGP and ENPP3 von den Hollander, W, Boer, C.G, Hart, D, Yau, M.S, Ramos, Y.F, Metrustry, S, Broer, L, Deelen, J, Beekman, M, Cupples, L.A, Rivadeneira, F, Kloppenburg, M, Peters, M, Spector, T.D, Hofman, A, Slagboom, P.E, Nelissen, R.G, Uitterlinden, A.G, Felson, D.T, Valdes, A, Meulenbelt, I, van Meurs, J.J

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Meta-analysis identifies novel genes influencing levels of the potential OA biomarkers sCOMP and uCTX2 von Ramos, Y.F, van Meurs, J.B, Valdes, A.M, Metrustry, S, Hart, D, Arden, N, Kloppenburg, M, Lafeber, F, van Spil, E.W, Karsdal, M, Bay-Jensen, A, Spector, T, Uitterlinden, A, Slagboom, P.E, Meulenbelt, I

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Timing, rates and spectra of human germline mutation von Rahbari, Raheleh, Wuster, Arthur, Lindsay, Sarah J, Hardwick, Robert J, Alexandrov, Ludmil B, Al Turki, Saeed, Dominiczak, Anna, Morris, Andrew, Porteous, David, Smith, Blair, Stratton, Michael R, Hurles, Matthew E

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348 A GENOME WIDE ASSOCIATION STUDY ON JOINT SPACE WIDTH IDENTIFIES A NEW GENE INVOLVED IN CARTILAGE THICKNESS AND OSTEOARTHRITIS von Betancourt, M.C. Castaño, Valdes, A, Cornells, F, Kerkhof, H, Doherty, S, Wheeler, M, Zhang, W, Maciewicz, R, Muir, K, Hart, D, Metrustry, S, Mangino, M, Arden, N, Cailotto, F, Peters, M, Rivadeneira, F, Hofman, A, Uitterlinden, A.G, Doherty, M, Spector, T, Lories, R, van Meurs, J.B

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83 ANALYSIS OF CANDIDATE OSTEOARTHRITIS GENES IN A META-ANALYSIS OF 8 GENOME-WIDE ASSOCIATION STUDIES von Rodriguez-Fontela, C, Evangelou, E, Valdes, A, Calaza, M, Arden, N.K, Bos, S, Cupples, A, Esko, T, Gomez-Reino, J, Helgadottir, H, Hofman, A, Jonsdottir, I, Kerkhof, H.J.M, Meulenbelt, I, Metrustry, S, Metspalu, A, van Meurs, J, Ntzani, E, Panoutsopoulou, K, Styrkarsdottir, U, Thorsteinsdottir, U, Thorleifsson, G, Zhu, Y, Felson, D, Ioannidis, J, Stefansson, K, Uitterlinden, A, Zeggini, E, Spector, T, Gonzalez, A

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Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study von Zeggini, Eleftheria, Panoutsopoulou, Kalliope, Southam, Lorraine, Rayner, Nigel W, Day-Williams, Aaron G, Lopes, Margarida C, Boraska, Vesna, Esko, Tonu, Evangelou, Evangelos, Hoffman, Albert, Houwing-Duistermaat, Jeanine J, Ingvarsson, Thorvaldur, Jonsdottir, Ingileif, Jonnson, Helgi, Kerkhof, Hanneke J, Kloppenburg, Margreet, Bos, Steffan D, Mangino, Massimo, Metrustry, Sarah, Slagboom, P Eline, Thorleifsson, Gudmar, Raine, Emma V A, Ratnayake, Madhushika, Ricketts, Michelle, Beazley, Claude, Blackburn, Hannah, Bumpstead, Suzannah, Elliott, Katherine S, Hunt, Sarah E, Potter, Simon C, Shin, So-Youn, Yadav, Vijay K, Zhai, Guangju, Sherburn, Kate, Dixon, Kate, Arden, Elizabeth, Aslam, Nadim, Battley, Phillippa-kate, Carluke, Ian, Doherty, Sally, Gordon, Andrew, Joseph, John, Keen, Richard, Koller, Nicola C, Mitchell, Sheryl, O'Neill, Fiona, Paling, Ellen, Reed, Mike R, Rivadeneira, Fernando, Swift, Diane, Walker, Kirsten, Watkins, Bridget, Wheeler, Maggie, Birrell, Fraser, Ioannidis, John P A, Meulenbelt, Ingrid, Metspalu, Andres, Rai, Ashok, Salter, Donald, Stefansson, Kari, Stykarsdottir, Unnur, Uitterlinden, André G, van Meurs, Joyce B J, Chapman, Kay, Deloukas, Panos, Ollier, William E R, Wallis, Gillian A, Arden, Nigel, Carr, Andrew, Doherty, Michael, McCaskie, Andrew, Willkinson, J Mark, Ralston, Stuart H, Valdes, Ana M, Spector, Tim D, Loughlin, John

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Mutations in GDP-Mannose Pyrophosphorylase B Cause Congenital and Limb-Girdle Muscular Dystrophies Associated with Hypoglycosylation of α-Dystroglycan von Carss, Keren J., Stevens, Elizabeth, Foley, A. Reghan, Cirak, Sebahattin, Riemersma, Moniek, Torelli, Silvia, Hoischen, Alexander, Willer, Tobias, van Scherpenzeel, Monique, Moore, Steven A., Messina, Sonia, Bertini, Enrico, Bönnemann, Carsten G., Abdenur, Jose E., Grosmann, Carla M., Kesari, Akanchha, Punetha, Jaya, Quinlivan, Ros, Waddell, Leigh B., Young, Helen K., Wraige, Elizabeth, Yau, Shu, Brodd, Lina, Feng, Lucy, Sewry, Caroline, MacArthur, Daniel G., North, Kathryn N., Hoffman, Eric, Stemple, Derek L., Hurles, Matthew E., van Bokhoven, Hans, Campbell, Kevin P., Lefeber, Dirk J., Lin, Yung-Yao, Muntoni, Francesco

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TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport von Schmidts, Miriam, Hou, Yuqing, Cortés, Claudio R., Mans, Dorus A., Huber, Celine, Boldt, Karsten, Patel, Mitali, van Reeuwijk, Jeroen, Plaza, Jean-Marc, van Beersum, Sylvia E. C., Yap, Zhi Min, Letteboer, Stef J. F., Taylor, S. Paige, Herridge, Warren, Johnson, Colin A., Scambler, Peter J., Ueffing, Marius, Kayserili, Hulya, Krakow, Deborah, King, Stephen M., Beales, Philip L., Al-Gazali, Lihadh, Wicking, Carol, Cormier-Daire, Valerie, Roepman, Ronald, Mitchison, Hannah M., Witman, George B.

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The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report von Chernomoretz, Ariel, Stolovitzky, Gustavo, Labaj, Pawel P., Graf, Alexandra B., Darling, Aaron, Burke, Catherine, Noushmehr, Houtan, Moraes, Milton Ozorio, Dias-Neto, Emmanuel, Guo, Yongli, Xie, Zhi, Lee, Patrick, Shi, Leming, Ruiz-Perez, Carlos A., Mercedes Zambrano, Maria, Siam, Rania, Ouf, Amged, Richard, Hugues, Lafontaine, Ingrid, Wieler, Lothar H., Semmler, Torsten, Ahmed, Niyaz, Prithi-Viraj, Bharath, Nedunuri, Narasimha, Mehr, Shaadi, Banihashemi, Kambiz, Lista, Florigio, Anselmo, Anna, Suzuki, Haruo, Kuroda, Makoto, Yamashita, Riu, Sato, Yukoto, Kaminuma, Eli, Alpuche Aranda, Celia M., Martinez, Jesus, Dada, Christopher, Dybwad, Marius, Oliveira, Manuela, Schuster, Stephan, Siwo, Geoffrey H., Jang, Soojin, Seo, Sung Chul, Hwang, Sung Ho, Ossowski, Stephan, Bezdan, Daniela, Chaker, Salama, Chatziefthimiou, Aspassia D., Udekwu, Klas, Liungdahl, Per, Sezerman, Ugur, Meydan, Cem, Elhaik, Eran, Gonnet, Gaston, Schriml, Lynn M., Mongodin, Emmanuel, Huttenhower, Curtis, Gilbert, Jack, Mason, Christopher E., Eisen, Jonathan, Hirschberg, David, Hernandez, Mark, Consortium, Metasub Int

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Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics von Beaumont, RN, Warrington, NM, Cavadino, A, Tyrrell, J, Nodzenski, M, Horikoshi, M, Geller, F, Myhre, R, Richmond, RC, Paternoster, L, Bradfield, JP, Kreiner-Moller, E, Huikari, V, Metrustry, S, Lunetta, KL, Painter, JN, Hottenga, J-J, Allard, C, Barton, SJ, Espinosa, A, Marsh, JA, Potter, C, Zhang, G, Ang, W, Berry, DJ, Bouchard, L, Das, S, Hakonarson, H, Heikkinen, J, Helgeland, O, Hocher, B, Hofman, A, Inskip, HM, Jones, SE, Kogevinas, M, Lind, PA, Marullo, L, Medland, SE, Murray, A, Murray, JC, Njolstad, PR, Nohr, EA, Reichetzeder, C, Ring, SM, Ruth, KS, Santa-Marina, L, Scholtens, DM, Sebert, S, Sengpiel, V, Tuke, MA, Vaudel, M, Weedon, MN, Willemsen, G, Wood, AR, Yaghootkar, H, Muglia, LJ, Bartels, M, Relton, CL, Pennell, CE, Chatzi, L, Estivill, X, Holloway, JW, Boomsma, DI, Montgomery, GW, Murabito, JM, Spector, TD, Power, C, Jarvelin, M-R, Bisgaard, H, Grant, SFA, Sorensen, TIA, Jaddoe, VW, Jacobsson, B, Melbye, M, McCarthy, MI, Hattersley, AT, Hayes, MG, Frayling, TM, Hivert, M-F, Felix, JF, Hypponen, E, Lowe, WL, Evans, DM, Lawlor, DA, Feenstra, B, Freathy, RM

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Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis von Castaño-Betancourt, MC, Evans, DS, Ramos, YF, Boer, CG, Metrustry, S, Liu, Y, Den Hollander, W, Van Rooij, J, Kraus, VB, Yau, MS, Mitchell, BD, Muir, K, Hofman, A, Doherty, M, Doherty, S, Zhang, W, Kraaij, R, Rivadeneira, F, Barrett-Connor, E, Maciewicz, RA, Arden, N, Nelissen, RG, Kloppenburg, M, Jordan, JM, Nevitt, MC, Slagboom, EP, Hart, DJ, Lafeber, F, Styrkarsdottir, U, Zeggini, E, Evangelou, E, Spector, TD, Uitterlinden, AG, Lane, NE, Meulenbelt, I, Valdes, AM, Van Meurs, JB

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The UK10K project identifies rare variants in health and disease von Walter, K, Min, JL, Huang, J, Crooks, L, McCarthy, S, Xu, C, Futema, M, Lawson, D, Iotchkova, V, Schiffels, S, Danecek, P, Wain, LV, Humphries, SE, Barrett, JC, Plagnol, V, Richards, JB, Soranzo, N, Bala, S, Cox, T, Du, Y, Ellis, P, Flicek, P, Huang, L, Keane, T, Li, Y, Liang, J, Maslen, J, Muddyman, D, Tian, J, Wang, G, Wang, J, Wong, K, Zhang, P, Boustred, C, Chen, L, Clement, G, Cocca, M, Geihs, M, Howie, B, Jamshidi, Y, Karczewski, KJ, Kemp, JP, Lopes, M, Mathieson, I, Metrustry, S, Quaye, L, Shin, S-Y, Small, KS, Artigas, MS, Spector, TD, St Pourcain, B, Tachmazidou, I, Valdes, AM, Yang, J, Craddock, N, Curtis, D, Gallagher, L, Geschwind, D, Gurling, H, Lee, I, McGuffin, P, McKechanie, AG, O'Donovan, MC, Pietilainen, O, Rehnstrom, K, Skuse, D, Bochukova, E, Farooqi, IS, Keogh, J, Wheeler, E, Al Turki, S, Anderson, CA, Beales, P, Carss, K, Cirak, S, Foley, AR, Franklin, CS, Grozeva, D, Roberts, N, Schmidts, M, Spasic-Boskovic, O, Stevens, E, Van Kogelenberg, M, Vijayarangakannan, P, Whyte, T, Oualkacha, K, Kent, A, Khawaja, F, Lopes, LR, Migone, N, Pollitt, RC, Scott, RH, Chambers, JC, Dedoussis, G, Gasparini, P, Isaacs, A, Langenberg, C, Luan, J, Benn, M, Toniolo, D

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Metabolomic signatures of low birthweight: pathways to insulin resistance and oxidative stress von Metrustry, SJ, Karhunen, V, Edwards, MH, Menni, C, Geisendorfer, T, Huber, A, Reichel, C, Dennison, EM, Cooper, C, Spector, T, Jarvelin, M-R, Valdes, AM

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A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip von Evangelou, E, Kerkhof, HJ, Styrkarsdottir, U, Ntzani, EE, Bos, SD, Esko, T, Evans, DS, Metrustry, S, Panoutsopoulou, K, Ramos, YF, Thorleifsson, G, Tsilidis, KK, ArcOGEN Consortium, Arden, N, Aslam, N, Bellamy, N, Birrell, F, Blanco, FJ, Carr, A, Chapman, K, Day-Williams, AG, Deloukas, P, Doherty, M, Engström, G, Helgadottir, HT, Hofman, A, Ingvarsson, T, Jonsson, H, Keis, A, Keurentjes, JC, Kloppenburg, M, Lind, PA, McCaskie, A, Martin, NG, Milani, L, Montgomery, GW, Nelissen, RG, Nevitt, MC, Nilsson, PM, Ollier, WE, Parimi, N, Rai, A, Ralston, SH, Reed, MR, Riancho, JA, Rivadeneira, F, Rodriguez-Fontenla, C, Southam, L, Thorsteinsdottir, U, Tsezou, A, Wallis, GA, Wilkinson, JM, Gonzalez, A, Lane, NE, Lohmander, LS, Loughlin, J, Metspalu, A, Uitterlinden, AG, Jonsdottir, I, Stefansson, K, Slagboom, PE, Zeggini, E, Meulenbelt, I, Ioannidis, JP, Spector, TD, Van Meurs, JB, Valdes, AM

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Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits von Tachmazidou, I, Suveges, D, Min, JL, Ritchie, GRS, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, AA, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, TR, Jousilahti, P, Kooijman, MN, Lehne, B, Malerba, G, Mannisto, S, Matchan, A, Medina-Gomez, C, Metrustry, SJ, Nag, A, Ntalla, I, Paternoster, L, Rayner, NW, Sala, C, Scott, WR, Shihab, HA, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, MS, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A, Luan, J, Manning, AK, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hendricks, AE, Kemp, JP, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, SG, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, McCarthy, MI, Morris, AP, Nordestgaard, BG, Scott, RA, Tobin, MD, Wareham, NJ, Burton, P, Chambers, JC, Smith, GD, Dedoussis, G, Franco, OH, Gambaro, G, Gasparini, P, Hammond, CJ, Hofman, A, Jaddoe, VWV, Kooner, JS, Perola, M, Relton, C, Ring, SM, Rivadeneira, F, Salomaa, V, Spector, TD, Stegle, O, Toniolo, D, Uitterlinden, AG, Barroso, I, Greenwood, CMT, Perry, JRB, Walker, BR, Butterworth, AS, Xue, Y, Durbin, R, Small, KS, Soranzo, N, Timpson, NJ, Zeggini, E

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Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight von Tyrrell, J, Richmond, RC, Palmer, TM, Feenstra, B, Rangarajan, J, Metrustry, S, Cavadino, A, Paternoster, L, Armstrong, LL, De Silva, NMG, Wood, AR, Horikoshi, M, Geller, F, Myhre, R, Bradfield, JP, Kreiner-Moller, E, Huikari, V, Painter, JN, Hottenga, J-J, Allard, C, Berry, DJ, Bouchard, L, Das, S, Evans, DM, Hakonarson, H, Hayes, MG, Heikkinen, J, Hofman, A, Knight, B, Lind, PA, McCarthy, MI, McMahon, G, Medland, SE, Melbye, M, Morris, AP, Nodzenski, M, Reichetzeder, C, Ring, SM, Sebert, S, Sengpiel, V, Sorensen, TIA, Willemsen, G, De Geus, EJC, Martin, NG, Spector, TD, Power, C, Jarvelin, M-R, Bisgaard, H, Grant, SFA, Nohr, EA, Jaddoe, VW, Jacobsson, B, Murray, JC, Hocher, B, Hattersley, AT, Scholtens, DM, Smith, GD, Hivert, M-F, Felix, JF, Hypponen, E, Lowe, WL, Frayling, TM, Lawlor, DA, Freathy, RM

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Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis von He, Y, Saito, K, Hinton, A, Yan, X, Mistry, V, Farooqi, IS, Xu, Y, Balasubramanian, S, Daly, A, Danecek, P, Du, Y, Ellis, P, Flicek, P, Huang, L, Keane, T, Li, Y, Maslen, J, Stalker, J, Tian, J, Wang, J, Birney, E, Boustred, C, Brion, M-J, Day, INM, Day-Williams, A, Gaunt, TR, Huang, J, Hubbard, T, Hysi, P, Jamshidi, Y, Kemp, JP, Lachance, G, Lopes, M, Mathieson, I, Metrustry, S, Perry, JRB, Ritchie, GRS, Schiffels, S, Shihab, HA, Small, KS, Artigas, MS, Southam, L, St Pourcain, B, Tachmazidou, I, Timpson, NJ, Tobin, MD, Wain, LV, Ward, K, Wilson, SG, Anney, R, Barrett, JC, Craddock, N, Crooks, L, Curran, S, Curtis, D, Gallagher, L, Lee, I, McGuffin, P, McKechanie, AG, Palotie, A, Pietilainen, O, Suvisaari, J, Bochukova, E, Porteous, DJ, Wheeler, E, Antony, D, Cosgrove, C, Grozeva, D, Humphries, SE, Hurles, ME, Mitchison, HM, Muntoni, F, Onoufriadis, A, Parker, V, Raymond, FL, Savage, DB, Serra, E, Whyte, T, Xu, C, Kaye, J, Ekong, R, Khawaja, F, Lopes, LR, Pollitt, RC, Povey, S, Robinson, RL, Shaw, A, Cocca, M, Dedoussis, G, Isaacs, A, Langenberg, C, Luan, J, Malerba, G, Marz, W, Matchan, A, Toniolo, D, Traglia, M, van Duijn, CM, van Leeuwen, EM, Zhang, W

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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume von Hayward, C, Felix, JF, Wang, C, Ahluwalia, TS, Sunyer, J, Walter, K, Cleal, L, Huffmann, J, Sass, L, Antony, D, Artigas, MS, Bala, S, Bentham, J, Blackwood, D, Cirak, S, Clapham, P, Coates, G, Cocca, M, Cox, T, Crooks, L, Curran, S, Curtis, D, Daly, A, Day, INM, Day-Williams, A, Dunham, I, Evans, DM, Franklin, CS, Geihs, M, Geschwind, D, Greenwood, CMT, Guo, X, Gurling, H, Huang, L, Hubbard, T, Humphries, SE, Hysi, P, Kent, A, van Kogelenberg, M, Kolb-Kokocinski, A, Langford, C, Li, Y, Lonnqvist, J, Lopes, LR, Lopes, M, MacArthur, DG, McCarthy, S, McGuffin, P, McIntosh, AM, McKechanie, AG, Metrustry, S, Mitchison, HM, Morris, A, Muddyman, D, Oualkacha, K, Palotie, A, Parker, V, Parr, JR, Paunio, T, Perry, JRB, Pietilainen, O, Quail, MA, Raymond, FL, Richards, JB, Ridout, CK, Robinson, RL, Savage, DB, Scambler, P, Schoenmakers, N, Serra, E, Shaw, A, Shin, S-Y, Small, KS, Smith, BH, Soranzo, N, Stevens, E, Suvisaari, J, Taylor, R, Tian, J, Tobin, MD, Valdes, AM, Vijayarangakannan, P, Visscher, PM, Wain, LV, Ward, K, Wheeler, E, Whyte, T, Williams, HJ, Williamson, KA, Wilson, C, Wilson, SG, Zhang, P, Cole, TJ, Bisgaard, H, Pennell, CE, Dedoussis, G, Timpson, N, Zeggini, E, Vitart, V, St Pourcain, B

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