Nucleophilic Phosphine Organocatalysis von Methot, Joey L., Roush, William R.

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Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function von Wang, Yun, Zhang, Kelvin, Georgiev, Peter, Wells, Steven, Xu, Haiyan, Lacey, Brian M., Xu, Zangwei, Laskey, Jason, Mcleod, Robbie, Methot, Joey L., Bittinger, Mark, Pasternak, Alexander, Ranganath, Sheila

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Synthetic Studies toward FR182877. Remarkable Solvent Effect in the Vinylogous Morita−Baylis−Hillman Cyclization von Methot, Joey L, Roush, William R

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High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry von Wen, Xiujuan, Liu, Chang, Tovar, Kiersten, Curran, Patrick, Richards, Matthew, Agrawal, Sony, Johnstone, Richard, Loy, Ryan E., Methot, Joey L., Mansueto, My Sam, Koglin, Markus, Wildey, Mary Jo, Burton, Lyle, Covey, Thomas R., Bateman, Kevin P., Kavana, Michael, McLaren, David G.

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SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2) von METHOT, Joey L, HAMBLETT, Christopher L, HONGMEI WANG, KRAL, Astrid M, OZEROVA, Nicole, CRUZ, Jonathan C, HAINES, Brian, CHENARD, Melissa, KENIFIC, Candia M, SECRIST, J. Paul, MILLER, Thomas A, MAMPREIAN, Dawn M, JUNG, Joon, HARSCH, Andreas, SZEWCZAK, Alexander A, DAHLBERG, William K, MIDDLETON, Richard E, HUGHES, Bethany, FLEMING, Judith C

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Identification of Potent Reverse Indazole Inhibitors for HPK1 von Yu, Elsie C, Methot, Joey L, Fradera, Xavier, Lesburg, Charles A, Lacey, Brian M, Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M, Xu, Zangwei, Piesvaux, Jennifer A, Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander

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Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators von Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors von Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.

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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors von Zhou, Hua, McGowan, Meredeth A., Lipford, Kathryn, Christopher, Matthew, Fradera, Xavier, Witter, David, Lesburg, Charles A., Li, Chaomin, Methot, Joey L., Lampe, John, Achab, Abdelghani, Shaffer, Lynsey, Goldenblatt, Peter, Shah, Sanjiv, Bass, Alan, Schroeder, Gottfried, Chen, Dapeng, Zeng, Haoyu, Augustin, Martin A., Katz, Jason D.

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Discovery of a new series of PI3K-δ inhibitors from Virtual Screening von Fradera, Xavier, Deng, Qiaolin, Achab, Abdelganhi, Garcia, Yudith, Kattar, Solomon D., McGowan, Meredeth A., Methot, Joey L., Wilson, Kevin, Zhou, Hua, Shaffer, Lynsey, Goldenblatt, Peter, Tong, Vincent, Augustin, Martin A, Altman, Michael D., Lesburg, Charles A., Shah, Sanjiv, Katz, Jason D.

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Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds von Vara, Brandon A, Levi, Samuel M, Achab, Abdelghani, Candito, David A, Fradera, Xavier, Lesburg, Charles A, Kawamura, Shuhei, Lacey, Brian M, Lim, Jongwon, Methot, Joey L, Xu, Zangwei, Xu, Haiyan, Smith, Dustin M, Piesvaux, Jennifer A, Miller, J. Richard, Bittinger, Mark, Ranganath, Sheila H, Bennett, David J, DiMauro, Erin F, Pasternak, Alexander

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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability von Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D

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Discovery of 1‑(1H‑Pyrazolo[4,3‑c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers von Lim, Jongwon, Kelley, Elizabeth H, Methot, Joey L, Zhou, Hua, Petrocchi, Alessia, Chen, Hongmin, Hill, Susan E, Hinton, Marlene C, Hruza, Alan, Jung, Joon O, Maclean, John K. F, Mansueto, My, Naumov, George N, Philippar, Ulrike, Raut, Shruti, Spacciapoli, Peter, Sun, Dongyu, Siliphaivanh, Phieng

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Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580] von Fradera, Xavier, Methot, Joey L., Achab, Abdelghani, Christopher, Matthew, Altman, Michael D., Zhou, Hua, McGowan, Meredeth A., Kattar, Sam D., Wilson, Kevin, Garcia, Yudith, Augustin, Martin A., Lesburg, Charles A., Shah, Sanjiv, Goldenblatt, Peter, Katz, Jason D.

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Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors von Methot, Joey L, Achab, Abdelghani, Christopher, Matthew, Zhou, Hua, McGowan, Meredeth A, Trotter, B. Wesley, Fradera, Xavier, Lesburg, Charles A, Goldenblatt, Peter, Hill, Armetta, Chen, Dapeng, Otte, Karin M, Augustin, Martin, Shah, Sanjiv, Katz, Jason D

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) von Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.

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Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities von Newbold, Andrea, Matthews, Geoffrey M, Bots, Michael, Cluse, Leonie A, Clarke, Christopher J P, Banks, Kellie-Marie, Cullinane, Carleen, Bolden, Jessica E, Christiansen, Ailsa J, Dickins, Ross A, Miccolo, Claudia, Chiocca, Susanna, Kral, Astrid M, Ozerova, Nicole D, Miller, Thomas A, Methot, Joey L, Richon, Victoria M, Secrist, J Paul, Minucci, Saverio, Johnstone, Ricky W

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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors von Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael

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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors von Lacey, Brian M., Xu, Zangwei, Chai, Xiaomei, Laskey, Jason, Fradera, Xavier, Mittal, Payal, Mishra, Sasmita, Piesvaux, Jennifer, Saradjian, Peter, Shaffer, Lynsey, Vassileva, Galya, Gerdt, Catherine, Wang, Yun, Ferguson, Heidi, Smith, Dustin M., Ballard, Jeanine, Wells, Steven, Jain, Rishabh, Mueller, Uwe, Addona, George, Kariv, Ilona, Methot, Joey L., Bittinger, Mark, Ranganath, Sheila, Mcleod, Robbie, Pasternak, Alexander, Miller, J. Richard, Xu, Haiyan

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