Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists von METCALFE, Ciara, DE SAUVAGE, Frederic J

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Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer von Munne, Pauliina M., Martikainen, Lahja, Räty, Iiris, Bertula, Kia, Nonappa, Ruuska, Janika, Ala-Hongisto, Hanna, Peura, Aino, Hollmann, Babette, Euro, Lilya, Yavuz, Kerim, Patrikainen, Linda, Salmela, Maria, Pokki, Juho, Kivento, Mikko, Väänänen, Juho, Suomi, Tomi, Nevalaita, Liina, Mutka, Minna, Kovanen, Panu, Leidenius, Marjut, Meretoja, Tuomo, Hukkinen, Katja, Monni, Outi, Pouwels, Jeroen, Sahu, Biswajyoti, Mattson, Johanna, Joensuu, Heikki, Heikkilä, Päivi, Elo, Laura L., Metcalfe, Ciara, Junttila, Melissa R., Ikkala, Olli, Klefström, Juha

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heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab f... von Kuemmel, Sherko, Harper-Wynne, Catherine, Park, Yeon Hee, Franke, Fábio, de Laurentiis, Michelino, Schumacher-Wulf, Eva, Eiger, Daniel, Heeson, Sarah, Cardona, Andrés, Özyilkan, Özgür, Morales-Vàsquez, Flavia, Metcalfe, Ciara, Hafner, Marc, Restuccia, Eleonora, O'Shaughnessy, Joyce

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Inhibition of GSK3 by Wnt signalling--two contrasting models von Metcalfe, Ciara, Bienz, Mariann

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Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer von Maulding, Nathan D, Zou, Jun, Zhou, Wei, Metcalfe, Ciara, Stuart, Joshua M, Ye, Xin, Hafner, Marc

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Abstract PD1-09: Constitutively active estrogen receptor mutants enhance breast cancer pathogenesis by co-opting progesterone receptor activity, which can be countered by Giredestr... von Liang, Jackson, Metcalfe, Ciara

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CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape von Chaudhary, Nayan, Chibly, Alejandro M., Collier, Ann, Martinalbo, Jorge, Perez-Moreno, Pablo, Moore, Heather M., Luhn, Patricia, Metcalfe, Ciara, Hafner, Marc

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Modeling targeted inhibition of MEK and PI3 kinase in human pancreatic cancer von Junttila, Melissa R, Devasthali, Vidusha, Cheng, Jason H, Castillo, Joseph, Metcalfe, Ciara, Clermont, Anne C, Otter, Douglas Den, Chan, Emily, Bou-Reslan, Hani, Cao, Tim, Forrest, William, Nannini, Michelle A, French, Dorothy, Carano, Richard, Merchant, Mark, Hoeflich, Klaus P, Singh, Mallika

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Therapeutic resistance to anti-oestrogen therapy in breast cancer von Will, Marie, Liang, Jackson, Metcalfe, Ciara, Chandarlapaty, Sarat

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Inhibition of ERα signaling induces lineage plasticity in vivo

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Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer von Joseph, James D, Darimont, Beatrice, Zhou, Wei, Arrazate, Alfonso, Young, Amy, Ingalla, Ellen, Walter, Kimberly, Blake, Robert A, Nonomiya, Jim, Guan, Zhengyu, Kategaya, Lorna, Govek, Steven P, Lai, Andiliy G, Kahraman, Mehmet, Brigham, Dan, Sensintaffar, John, Lu, Nhin, Shao, Gang, Qian, Jing, Grillot, Kate, Moon, Michael, Prudente, Rene, Bischoff, Eric, Lee, Kyoung-Jin, Bonnefous, Celine, Douglas, Karensa L, Julien, Jackaline D, Nagasawa, Johnny Y, Aparicio, Anna, Kaufman, Josh, Haley, Benjamin, Giltnane, Jennifer M, Wertz, Ingrid E, Lackner, Mark R, Nannini, Michelle A, Sampath, Deepak, Schwarz, Luis, Manning, Henry Charles, Tantawy, Mohammed Noor, Arteaga, Carlos L, Heyman, Richard A, Rix, Peter J, Friedman, Lori, Smith, Nicholas D, Metcalfe, Ciara, Hager, Jeffrey H

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Dynamic recruitment of axin by Dishevelled protein assemblies von Schwarz-Romond, Thomas, Metcalfe, Ciara, Bienz, Mariann

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Abstract 6323: Identification of genomic alterations related to treatment progression in RWD von Chaudhary, Nayan, Luhn, Patricia, Jansen, Gunther, Metcalfe, Ciara, Hafner, Marc

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Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility von Guan, Jane, Zhou, Wei, Hafner, Marc, Blake, Robert A., Chalouni, Cecile, Chen, Irene P., De Bruyn, Tom, Giltnane, Jennifer M., Hartman, Steven J., Heidersbach, Amy, Houtman, Rene, Ingalla, Ellen, Kategaya, Lorn, Kleinheinz, Tracy, Li, Jun, Martin, Scott E., Modrusan, Zora, Nannini, Michelle, Oeh, Jason, Ubhayakar, Savita, Wang, Xiaojing, Wertz, Ingrid E., Young, Amy, Yu, Mamie, Sampath, Deepak, Hager, Jeffrey H., Friedman, Lori S., Daemen, Anneleen, Metcalfe, Ciara

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Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization von Metcalfe, Ciara, Mendoza-Topaz, Carolina, Mieszczanek, Juliusz, Bienz, Mariann

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Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function von Storm, Elaine E., Durinck, Steffen, de Sousa e Melo, Felipe, Tremayne, Jarrod, Kljavin, Noelyn, Tan, Christine, Ye, Xiaofen, Chiu, Cecilia, Pham, Thinh, Hongo, Jo-Anne, Bainbridge, Travis, Firestein, Ron, Blackwood, Elizabeth, Metcalfe, Ciara, Stawiski, Eric W., Yauch, Robert L., Wu, Yan, de Sauvage, Frederic J.

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Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer von METCALFE, Ciara, IBRAHIM, Ashraf E. K, GRAEB, Michael, DE LA ROCHE, Marc, SCHWARZ-ROMON, Thomas, FIEDLER, Marc, WINTON, Douglas J, CORFIELD, Anthony, BIENZ, Mariann

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer von Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing

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Abstract 1004: Leveraging an expanding tool box for ER+ breast cancer: exploring breast cancer dependencies to support optimal therapeutic strategies von Zhou, Wei, Guan, Jane, Hatzivassiliou, Georgia, Daemen, Anneleen, Hafner, Marc, Metcalfe, Ciara

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An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer von Chandarlapaty, Sarat, Dickler, Maura N, Perez Fidalgo, Jose Alejandro, Villanueva-Vázquez, Rafael, Giltnane, Jennifer, Gates, Mary, Chang, Ching-Wei, Cheeti, Sravanthi, Fredrickson, Jill, Wang, Xiaojing, Collier, Ann, Moore, Heather M, Metcalfe, Ciara, Lauchle, Jennifer, Humke, Eric W, Bardia, Aditya

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