Predictors of responses to immune checkpoint blockade in advanced melanoma von Jacquelot, N., Roberti, M. P., Enot, D. P., Rusakiewicz, S., Ternès, N., Jegou, S., Woods, D. M., Sodré, A. L., Hansen, M., Meirow, Y., Sade-Feldman, M., Burra, A., Kwek, S. S., Flament, C., Messaoudene, M., Duong, C. P. M., Chen, L., Kwon, B. S., Anderson, A. C., Kuchroo, V. K., Weide, B., Aubin, F., Borg, C., Dalle, S., Beatrix, O., Ayyoub, M., Balme, B., Tomasic, G., Di Giacomo, A. M., Maio, M., Schadendorf, D., Melero, I., Dréno, B., Khammari, A., Dummer, R., Levesque, M., Koguchi, Y., Fong, L., Lotem, M., Baniyash, M., Schmidt, H., Svane, I. M., Kroemer, G., Marabelle, A., Michiels, S., Cavalcanti, A., Smyth, M. J., Weber, J. S., Eggermont, A. M., Zitvogel, L.

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T-cell bispecific antibodies in node-positive breast cancer: novel therapeutic avenue for MHC class I loss variants von Messaoudene, M., Mourikis, T.P., Michels, J., Fu, Y., Bonvalet, M., Lacroix-Trikki, M., Routy, B., Fluckiger, A., Rusakiewicz, S., Roberti, M.P., Cotteret, S., Flament, C., Poirier-Colame, V., Jacquelot, N., Ghiringhelli, F., Caignard, A., Eggermont, A.M.M., Kroemer, G., Marabelle, A., Arnedos, M., Vicier, C., Dogan, S., Jaulin, F., Sammut, S -J, Cope, W., Caldas, C., Delaloge, S., McGranahan, N., André, F., Zitvogel, L.

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Paraparésie spastique héréditaire, profils locomoteurs et proximité génétique von Delpierre, Y, Deries, X, Messaoudene, M, Vernet, P, Colin, D

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Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade von Jacquelot, Nicolas, Yamazaki, Takahiro, Roberti, Maria P., Duong, Connie P. M., Andrews, Miles C., Verlingue, Loic, Ferrere, Gladys, Becharef, Sonia, Vétizou, Marie, Daillère, Romain, Messaoudene, Meriem, Enot, David P., Stoll, Gautier, Ugel, Stefano, Marigo, Ilaria, Foong Ngiow, Shin, Marabelle, Aurélien, Prevost-Blondel, Armelle, Gaudreau, Pierre-Olivier, Gopalakrishnan, Vancheswaran, Eggermont, Alexander M., Opolon, Paule, Klein, Christophe, Madonna, Gabriele, Ascierto, Paolo A., Sucker, Antje, Schadendorf, Dirk, Smyth, Mark J., Soria, Jean-Charles, Kroemer, Guido, Bronte, Vincenzo, Wargo, Jennifer, Zitvogel, Laurence

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1068P Phase II trial of fecal microbiota transplantation (FMT) plus immune checkpoint inhibition (ICI) in advanced non-small cell lung cancer and cutaneous melanoma (FMT-LUMINate) von Elkrief, A., Duttagupta, S., Jamal, R., Marcoux, N., Desilets, A., Messaoudene, M., Mihalcioiu, C., Durand, S., Tehfe, M., Blais, N., Owen, S., Raphael, J., Lenehan, J.G., Parvathy, S.N., Derosa, L., Zitvogel, L., Kroemer, G., Silverman, M., Maleki Vareki, S., Routy, B.

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1663MO DAV132 prevents antibiotic-induced intestinal microbiota dysbiosis and maintains anti-PD-1 efficacy: A proof-of-concept in tumor-bearing mice transplanted with human feces von Messaoudene, M., Saint-Lu, N., Sablier-Gallis, F., Ferreira, S., Le Bescop, C., Ponce, M., Féger, C., Andremont, A., de Gunzburg, J., Routy, B.

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CN12 Impact of diet on immune checkpoint blockade: Nurse-directed dietary intervention von Malo, J., Benlaïfaoui, M., Diop, K., Messaoudene, M., Belkaid, W., Elkrief, A., Blais, N., Tehfe, M., Florescu, M., Al-Saleh, A., Leblanc, A., Marcil, V., Routy, B., Richard, C.

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901P Gut microbiome metagenomics and toxicity outcomes from chemoradiation therapy in head and neck squamous cell carcinoma von Desilets, A., Hermosilla Samayoa, C., Tonneau, M., El Ouarzadi, O., De Figueiredo Sousa, M., Bahig, H., Malo, J., Belkaid, W., Benlaïfaoui, M., Ponce, M., Derosa, L., Filion, E., Nguyen-Tan, P.F., Charpentier, D., Aubin, F.M., Hamilou, Z., Jamal, R., Routy, B., Messaoudene, M., Soulieres, D.

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TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer von Ivagnès, Alexandre, Messaoudene, Meriem, Stoll, Gautier, Routy, Bertrand, Fluckiger, Aurélie, Yamazaki, Takahiro, Iribarren, Kristina, Duong, Connie P. M., Fend, Laetitia, Caignard, Anne, Cremer, Isabelle, LeCesne, Axel, Adam, Julien, Honoré, Charles, Mir, Olivier, Chaigneau, Loïc, Berger, Anne, Validire, Pierre, Christidis, Christos, Brun-Ly, Valérie Le, Smyth, Mark J., Mariette, Xavier, Salomon, Benoît L., Kroemer, Guido, Rusakiewicz, Sylvie, Zitvogel, Laurence

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P807Baseline characteristics and outcome of the resynchronization therapy in patients with valvular heart disease: single-center experience von Benkouar, RHIAD, Ait Messaoudene, M S, Aoudia, Y, Boumedien, T, Ali Tatar, N, Bouhouita, Y

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Cancer patient participation and compliance in microbiome sample collection: An oncology research nurse’s experience von Malo, J., Messaoudene, M., Cauchois, F., Belkaid, W., Frizon-Peresa, D., Ikene, S., Rousseau, L., Lattouf, J.-B., Elkrief, A., Mezquita, L., Derosa, L., Besse, B., Blais, N., Alameddine, R., Tehfe, M., Florescu, M., Routy, B.

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CN111 - Cancer patient participation and compliance in microbiome sample collection: An oncology research nurse’s experience von Malo, J., Messaoudene, M., Cauchois, F., Belkaid, W., Frizon-Peresa, D., Ikene, S., Rousseau, L., Lattouf, J.-B., Elkrief, A., Mezquita, L., Derosa, L., Besse, B., Blais, N., Alameddine, R., Tehfe, M., Florescu, M., Routy, B.

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CN111Cancer patient participation and compliance in microbiome sample collection: An oncology research nurse’s experience von Malo, J, Messaoudene, M, Cauchois, F, Belkaid, W, Frizon-Peresa, D, Ikene, S, Rousseau, L, Lattouf, J-B, Elkrief, A, Mezquita, L, Derosa, L, Besse, B, Blais, N, Alameddine, R, Tehfe, M, Florescu, M, Routy, B

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Potentiel anti-tumoral des cellules Natural Killer circulantes et infiltrant les métastases ganglionnaires des patients atteints de mélanome à différents stades évolutifs von Messaoudene, M., Fourmentraux-Neves, E., Fregni, G., Chanal, J., Avril, M.-F., Caignard, A.

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Prognostic impact of the expression of NCR1 and NCR3 NK cell receptors and PD-L1 on advanced non-small cell lung cancer von Fend, Laetitia, Rusakiewicz, Sylvie, Adam, Julien, Bastien, Bérangère, Caignard, Anne, Messaoudene, Meriem, Iribarren, Christina, Cremer, Isabelle, Marabelle, Aurélien, Borg, Christophe, Semeraro, Michaela, Barraud, Luc, Limacher, Jean-Marc, Eggermont, Alexander, Kroemer, Guido, Zitvogel, Laurence

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73P Correlation between diet, microbiome composition and clinical outcomes in patients with non-small cell lung cancer von Malo, J., Benlaïfaoui, M., Lehoux-Dubois, C., Salazar, E. Mendez, Diop, K., Ponce, M., Kourtian, S., Maillou, J., Moreau-Amaru, D., Duttagupta, S., Belkaid, W., Blais, N., Tehfe, M., Florescu, M., Elkrief, A., Messaoudene, M., Marcil, V., Routy, B.

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Expression des ligands des cellules NK par les cellules de mélanomes en réponse au traitement von Neves, E., Messaoudene, M., Chanal, J., Avril, M.-F., Caignard, A.

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Predictors of responses to immune checkpoint blockade in advanced melanoma von Jacquelot, N, Roberti, M P, Enot, D P, Rusakiewicz, S, Ternès, N, Jegou, S, Woods, D M, Sodré, A L, Hansen, M, Meirow, Y, Sade-Feldman, M, Burra, A, Kwek, S S, Flament, C, Messaoudene, M, Duong, C P M, Chen, L, Kwon, B S, Anderson, A C, Kuchroo, V K, Weide, B, Aubin, F, Borg, C, Dalle, S, Beatrix, O, Ayyoub, M, Balme, B, Tomasic, G, Di Giacomo, A M, Maio, M

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614 Microbiome modification with fecal microbiota transplant from healthy donors before anti-PD1 therapy reduces primary resistance to immunotherapy in advanced and metastatic mela... von Routy, B, Lenehan, J, Daisley, B, Messaoudene, M, Al, K, Richard, C, Miller, W, Jamal, R, Ernst, S, Logan, D, Belanger, K, Gili, LM, Mullish, B, Takis, P, Samayoa, CH, Ninkov, M, Parvathy, SN, Lambert, C, Elkrief, A, Lapointe, R, Haeryfar, M, Burton, J, Silverman, M, Maleki, S

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French title von Delpierre, Y, Deries, X, Messaoudene, M, Vernet, P, Colin, D

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