A66 PH: MOLECULES, CELLS AND ANIMAL MODELS: Bmpr2 Deficiency Potentiates The Ltb4 Mediated Paec Transformation In Pah von Tian, W, Jiang, X, Qian, J, Tu, A, Shuffle, E, Mesange, P, Nicolls, M

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1582PNATURAL BEVACIZUMAB RESISTANCE IS ASSOCIATED WITH HYPOXIA TOLERANCE AND PROLONGED ACTIVATION OF AUTOCRINE VEGF SIGNALING IN COLORECTAL CANCER CELLS AND CAN BE OVERCOME BY NINT... von Mesange, P., Poindessous, V., Sabbah, M., Escargueil, A.E., De Gramont, A., Larsen, A.K.

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Natural Bevacizumab Resistance is Associated with Hypoxia Tolerance and Prolonged Activation of Autocrine Vegf Signaling in Colorectal Cancer Cells and Can Be Overcome By Nintedani... von Mesange, P., Poindessous, V., Sabbah, M., Escargueil, A.E., De Gramont, A., Larsen, A.K.

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P-221 Acquired 5-FU resistance in CRC models is accompanied by upregulation of VEGF-VEGFR1 signaling, increased migration and invasion that can be attenuated by aflibercept von Bouygues, A., Mesange, P., Ayadi, M., Chiron, M., Dochy, E., Andre, T., de Gramont, A., Larsen, A.

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Mouse-Dream: Vegf Inhibition is Accompanied By Egfr Activation in Colorectal Cancer Models Independent of Kras Status Providing a Rational for Combinations of Bevacizumab and Erlot... von Larsen, A.K., Poindessous, V., Bouygues, A., Muller, D., Savina, A., Chibaudel, B., Tournigand, C., André, T., De Gramont, A., Mesange, P.

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1581PMOUSE-DREAM: VEGF INHIBITION IS ACCOMPANIED BY EGFR ACTIVATION IN COLORECTAL CANCER MODELS INDEPENDENT OF KRAS STATUS PROVIDING A RATIONAL FOR COMBINATIONS OF BEVACIZUMAB AND... von Larsen, A.K., Poindessous, V., Bouygues, A., Muller, D., Savina, A., Chibaudel, B., Tournigand, C., André, T., De Gramont, A., Mesange, P.

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1144P When AI-based image analysis gets in clinical trials von Mésange, P., Bonnet, M., Deen, J.

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406 Aflibercept (Zaltrap) directly attenuates the migration and invasion of colorectal cancer cells von Bouygues, A, Mésange, P, Ayadi, M, Poindessous, V, Chiron, M, Dochy, E, André, T, de Gramont, A, Larsen, A.K

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497OBEVACIZUMAB-ERLOTINIB AS MAINTENANCE THERAPY IN METASTATIC COLORECTAL CANCER. FINAL RESULTS OF THE GERCOR DREAM STUDY von Chibaudel, B., Tournigand, C., Samson, B., Scheithauer, W., Mesange, P., Lledo, G., Viret, F., Ramée, J.F., Tubiana-Mathieu, N., Dauba, J., Dupuis, O., Rinaldi, Y., Mabro, M., Aucoin, N., Latreille, J., Bonnetain, F., Louvet, C., Larsen, A.K., André, T., De Gramont, A.

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Bevacizumab-Erlotinib As Maintenance Therapy in Metastatic Colorectal Cancer. Final Results of the Gercor Dream Study von Chibaudel, B., Tournigand, C., Samson, B., Scheithauer, W., Mesange, P., Lledo, G., Viret, F., Ramée, J.F., Tubiana-Mathieu, N., Dauba, J., Dupuis, O., Rinaldi, Y., Mabro, M., Aucoin, N., Latreille, J., Bonnetain, F., Louvet, C., Larsen, A.K., André, T., De Gramont, A.

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PD-010 Erlotinib attenuates bevacizumab-mediated activation of EGFR-survival signaling in CRC models independent of KRAS status providing a rational basis for the DREAM phase III c... von Mésange, P., Bouygues, A., Muller, D., Savina, A., Chibaudel, B., Tournigand, C., André, T., de Gramont, A., Larsen, A.

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A Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension von Tamosiuniene, Rasa, Manouvakhova, Olga, Mesange, Paul, Saito, Toshi, Qian, Jin, Sanyal, Mrinmoy, Lin, Yu-Chin, Nguyen, Linh P, Luria, Amir, Tu, Allen B, Sante, Joshua M, Rabinovitch, Marline, Fitzgerald, Desmond J, Graham, Brian BB, Habtezion, Aida, Voelkel, Norbert F, Aurelian, Laure, Nicolls, Mark R

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A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia von De Toni, F, Racaud-Sultan, C, Chicanne, G, Mas, V Mansat-De, Cariven, C, Mesange, F, Salles, J-P, Demur, C, Allouche, M, Payrastre, B, Manenti, S, Ysebaert, L

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DNA alkylation damage and autophagy induction von Bordin, Diana L., Lima, Michelle, Lenz, Guido, Saffi, Jenifer, Meira, Lisiane B., Mésange, Paul, Soares, Daniele G., Larsen, Annette K., Escargueil, Alexandre E., Henriques, João A.P.

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Apoptotic Effect of Sphingosine 1-Phosphate and Increased Sphingosine 1-Phosphate Hydrolysis on Mesangial Cells Cultured at Low Cell Density von Gennero, Isabelle, Fauvel, Josette, Niéto, Michèle, Cariven, Clotilde, Gaits, Frédérique, Briand-Mésange, Fabienne, Chap, Hugues, Salles, Jean Pierre

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Identification of Two Tamoxifen Target Proteins by Photolabeling with 4-(2-Morpholinoethoxy)benzophenone von Mésange, Fabienne, Sebbar, Mohamed, Capdevielle, Joël, Guillemot, Jean-Claude, Ferrara, Pascual, Bayard, Francis, Poirot, Marc, Faye, Jean-Charles

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A lysophosphatidic acid analogue is revealed as a potent inhibitor of phosphatidylcholine synthesis, inducing apoptosis von Gueguen, Geneviéve, Granci, Virginie, Rogalle, Pierre, Briand-Mésange, Fabienne, Wilson, Michéle, Klaébé, Alain, Tercé, François, Chap, Hugues, Salles, Jean-Pierre, Simon, Marie-Françoise, Gaits, Frédérique

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Microsomal epoxide hydrolase of rat liver is a subunit of the anti-oestrogen-binding site von Mésange, Fabienne, Sebbar, Mohamed, Kedjouar, Blandine, Capdevielle, Joël, Guillemot, Jean-Claude, Ferrara, Pascual, Bayard, Francis, Delarue, Frédéric, Faye, Jean-Charles, Poirot, Marc E.

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FGF 23 et phosphatémie von Salles, J.–P., Moulin, P., Briand-Mésange, F., Conte-Auriol, F., Gennero, I., Tauber, M., Fauvel, J.

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Microsomal epoxide hydrolase of rat liver is a subunit of theanti-oestrogen-binding site von Mésange, F, Sebbar, M, Kedjouar, B, Capdevielle, J, Guillemot, J C, Ferrara, P, Bayard, F, Delarue, F, Faye, J C, Poirot, M

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