Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists von Gillis, Alexander, Gondin, Arisbel B, Kliewer, Andrea, Sanchez, Julie, Lim, Herman D, Alamein, Claudia, Manandhar, Preeti, Santiago, Marina, Fritzwanker, Sebastian, Schmiedel, Frank, Katte, Timothy A, Reekie, Tristan, Grimsey, Natasha L, Kassiou, Michael, Kellam, Barrie, Krasel, Cornelius, Halls, Michelle L, Connor, Mark, Lane, J Robert, Schulz, Stefan, Christie, Macdonald J, Canals, Meritxell

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The role of kinetic context in apparent biased agonism at GPCRs von Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert

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Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs von Dror, Ron O., Green, Hillary F., Valant, Celine, Borhani, David W., Valcourt, James R., Pan, Albert C., Arlow, Daniel H., Canals, Meritxell, Lane, J. Robert, Rahmani, Raphaël, Baell, Jonathan B., Sexton, Patrick M., Christopoulos, Arthur, Shaw, David E.

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New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling von Mann, Anika, Keen, Alastair C., Mark, Hanka, Dasgupta, Pooja, Javitch, Jonathan A., Canals, Meritxell, Schulz, Stefan, Robert Lane, J.

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Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization von Miess, Elke, Gondin, Arisbel B, Yousuf, Arsalan, Steinborn, Ralph, Mösslein, Nadja, Yang, Yunshi, Göldner, Martin, Ruland, Julia G, Bünemann, Moritz, Krasel, Cornelius, Christie, MacDonald J, Halls, Michelle L, Schulz, Stefan, Canals, Meritxell

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Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity von Kirchhofer, Sina B, Lim, Victor Jun Yu, Ernst, Sebastian, Karsai, Noemi, Ruland, Julia G, Canals, Meritxell, Kolb, Peter, Bünemann, Moritz

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Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations von Civciristov, Srgjan, Ellisdon, Andrew M, Suderman, Ryan, Pon, Cindy K, Evans, Bronwyn A, Kleifeld, Oded, Charlton, Steven J, Hlavacek, William S, Canals, Meritxell, Halls, Michelle L

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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome von Jimenez-Vargas, Nestor N., Pattison, Luke A., Zhao, Peishen, Lieu, TinaMarie, Latorre, Rocco, Jensen, Dane D., Castro, Joel, Aurelio, Luigi, Le, Giang T., Flynn, Bernard, Herenbrink, Carmen Klein, Yeatman, Holly R., Edgington-Mitchell, Laura, Porter, Christopher J. H., Halls, Michelle L., Canals, Meritxell, Veldhuis, Nicholas A., Poole, Daniel P., McLean, Peter, Hicks, Gareth A., Scheff, Nicole, Chen, Elyssa, Bhattacharya, Aditi, Schmidt, Brian L., Brierley, Stuart M., Vanner, Stephen J., Bunnett, Nigel W.

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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission von Yarwood, Rebecca E., Imlach, Wendy L., Lieu, TinaMarie, Veldhuis, Nicholas A., Jensen, Dane D., Herenbrink, Carmen Klein, Aurelio, Luigi, Cai, Zhijian, Christie, MacDonald J., Poole, Daniel P., Porter, Christopher J. H., McLean, Peter, Hicks, Gareth A., Geppetti, Pierangelo, Halls, Michelle L., Canals, Meritxell, Bunnett, Nigel W.

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Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors von Canals, Meritxell, Milligan, Graeme

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Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor von Thompson, Georgina L., Lane, J. Robert, Coudrat, Thomas, Sexton, Patrick M., Christopoulos, Arthur, Canals, Meritxell

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Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors von Shang, Yi, Yeatman, Holly R, Provasi, Davide, Alt, Andrew, Christopoulos, Arthur, Canals, Meritxell, Filizola, Marta

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Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function von Ellis, James, Pediani, John D., Canals, Meritxell, Milasta, Sandra, Milligan, Graeme

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Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors von Lane, J. Robert, Chubukov, Pavel, Liu, Wei, Canals, Meritxell, Cherezov, Vadim, Abagyan, Ruben, Stevens, Raymond C., Katritch, Vsevolod

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Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2 von Huang, Cheng, Foster, Simon R., Shah, Anup D., Kleifeld, Oded, Canals, Meritxell, Schittenhelm, Ralf B., Stone, Martin J.

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The α1b-Adrenoceptor Exists as a Higher-Order Oligomer: Effective Oligomerization Is Required for Receptor Maturation, Surface Delivery, and Function von Lopez-Gimenez, Juan F., Canals, Meritxell, Pediani, John D., Milligan, Graeme

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Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells von Idris, Aymen I., Sophocleous, Antonia, Landao-Bassonga, Euphemie, Canals, Meritxell, Milligan, Graeme, Baker, David, van't Hof, Robert J., Ralston, Stuart H.

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GRKs as Key Modulators of Opioid Receptor Function von Lemel, Laura, Lane, J Robert, Canals, Meritxell

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Experimental considerations for the assessment of in vivo and in vitro opioid pharmacology von Hill, Rob, Canals, Meritxell

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Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1 von Millard, Christopher J., Ludeman, Justin P., Canals, Meritxell, Bridgford, Jessica L., Hinds, Mark G., Clayton, Daniel J., Christopoulos, Arthur, Payne, Richard J., Stone, Martin J.

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