TNFα-Induced Mucin 4 Expression Elicits Trastuzumab Resistance in HER2-Positive Breast Cancer von Mercogliano, María F, De Martino, Mara, Venturutti, Leandro, Rivas, Martín A, Proietti, Cecilia J, Inurrigarro, Gloria, Frahm, Isabel, Allemand, Daniel H, Deza, Ernesto Gil, Ares, Sandra, Gercovich, Felipe G, Guzmán, Pablo, Roa, Juan C, Elizalde, Patricia V, Schillaci, Roxana

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Blocking soluble TNFα sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression von Bruni, Sofia, Mauro, Florencia L, Proietti, Cecilia J, Cordo-Russo, Rosalia I, Rivas, Martin A, Inurrigarro, Gloria, Dupont, Agustina, Rocha, Dario, Fernández, Elmer A, Deza, Ernesto Gil, Lopez Della Vecchia, Daniel, Barchuk, Sabrina, Figurelli, Silvina, Lasso, David, Friedrich, Adrián D, Santilli, María C, Regge, María V, Lebersztein, Gabriel, Levit, Claudio, Anfuso, Fabiana, Castiglione, Teresa, Elizalde, Patricia V, Mercogliano, Maria F, Schillaci, Roxana

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Expanding spectrum, intrafamilial diversity, and therapeutic challenges from 15 patients with heterozygous CARD11-associated diseases: A single center experience von Urdinez, Luciano, Erra, Lorenzo, Palma, Alejandro M, Mercogliano, María F, Fernandez, Julieta Belén, Prieto, Emma, Goris, Verónica, Bernasconi, Andrea, Sanz, Marianela, Villa, Mariana, Bouso, Carolina, Caputi, Lucia, Quesada, Belen, Solis, Daniel, Aguirre Bruzzo, Anabel, Katsicas, Maria Martha, Galluzzo, Laura, Weyersberg, Christian, Bocian, Marcela, Bujan, Maria Marta, Oleastro, Matías, Almejun, María B, Danielian, Silvia

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Invasive micropapillary carcinoma of the breast overexpresses MUC4 and is associated with poor outcome to adjuvant trastuzumab in HER2-positive breast cancer von Mercogliano, María F, Inurrigarro, Gloria, De Martino, Mara, Venturutti, Leandro, Rivas, Martín A, Cordo-Russo, Rosalía, Proietti, Cecilia J, Fernández, Elmer A, Frahm, Isabel, Barchuk, Sabrina, Allemand, Daniel H, Figurelli, Silvina, Deza, Ernesto Gil, Ares, Sandra, Gercovich, Felipe G, Cortese, Eduardo, Amasino, Matías, Guzmán, Pablo, Roa, Juan C, Elizalde, Patricia V, Schillaci, Roxana

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495 INB03: a new immune checkpoint inhibitor that reprograms polarization and promotes ADCP in human macrophages von Bruni, Sofia, Mercogliano, Maria F, Schillaci, Roxana

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Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer von Madera, Santiago, Izzo, Franco, Chervo, María F., Dupont, Agustina, Chiauzzi, Violeta A., Bruni, Sofia, Petrillo, Ezequiel, Merin, Sharon S., De Martino, Mara, Montero, Diego, Levit, Claudio, Lebersztein, Gabriel, Anfuso, Fabiana, Roldán Deamicis, Agustina, Mercogliano, María F., Proietti, Cecilia J., Schillaci, Roxana, Elizalde, Patricia V., Cordo Russo, Rosalía I.

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Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy von De Martino, Mara, Tkach, Mercedes, Bruni, Sofía, Rocha, Darío, Mercogliano, María F., Cenciarini, Mauro E., Chervo, María F., Proietti, Cecilia J., Dingli, Florent, Loew, Damarys, Fernández, Elmer A., Elizalde, Patricia V., Piaggio, Eliane, Schillaci, Roxana

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Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer von Madera, Santiago, Izzo, Franco, Chervo, María F., Dupont, Agustina, Chiauzzi, Violeta A., Bruni, Sofia, Petrillo, Ezequiel, Merin, Sharon S., De Martino, Mara, Montero, Diego, Levit, Claudio, Lebersztein, Gabriel, Anfuso, Fabiana, Roldán Deamicis, Agustina, Mercogliano, María F., Proietti, Cecilia J., Schillaci, Roxana, Elizalde, Patricia V., Cordo Russo, Rosalía I.

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Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, f... von Wiebe, John P., Rivas, Martin A., Mercogliano, Maria F., Elizalde, Patricia V., Schillaci, Roxana

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Abstract 2273: Soluble TNFα blockade improves effectiveness of trastuzumab deruxtecan and boosts antitumor potential of macrophages in a HER2+ tumor model von Bruni, Sofia, Mauro, Florencia L., Naveiro, Sofia, Mercogliano, Maria F., Schillaci, Roxana

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Abstract 2047: MUC4 enables immune tumor evasion in HER2+ breast cancer von Bruni, Sofia, Mauro, Florencia L., Mercogliano, Maria F., Proietti, Cecilia J., Adami, Carla, Dupont, Agustina, Inurrigarro, Gloria, Russo, Rosalia Cordo, Elizalde, Patricia V., Schillaci, Roxana

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Abstract 344: Blockade of retrograde transport in triple negative breast cancer excludes ErbB-2 isoforms from the nucleus and abrogates tumor growth von Madera, Santiago, Izzo, Franco, Chervo, Maria F., Dupont, Agustina, Chiauzzi, Violeta A., Bruni, Sofia, Petrillo, Ezequiel, Montero, Diego, Merin, Sharon, Mercogliano, Maria F., Proietti, Cecilia J., Schillaci, Roxana, Russo, Rosalia I. Cordo, Elizalde, Patricia V.

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Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer grow... von Díaz Flaqué, María C, Galigniana, Natalia M, Béguelin, Wendy, Vicario, Rocío, Proietti, Cecilia J, Russo, Rosalía, Rivas, Martín A, Tkach, Mercedes, Guzmán, Pablo, Roa, Juan C, Maronna, Esteban, Pineda, Viviana, Muñoz, Sergio, Mercogliano, María, Charreau, Eduardo H, Yankilevich, Patricio, Schillaci, Roxana, Elizalde, Patricia V

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Abstract P5-13-32: Mucin 4 expression in high risk breast cancer: Predicting and overcoming resistance to immunotherapy von Schillaci, Roxana, Bruni, Sofia, Mauro, Florencia, Mercogliano, María F, Roldan-Deamicis, Agustina, Proietti, Cecilia J, Cordo-Russo, Rosalía, Inurrigarro, Gloria, Dupont, Agustina, Adami, Carla, Vecchia, Daniel Lopez Della, Barchuck, Sabrina, Figurelli, Silvina, Deza, Ernesto Gil, Ares, Sandra, Gercovich, Felipe G, Elizalde, Patricia V

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Abstract 3633: Exploring a novel crosstalk between hyluronan/CD44 and ErbB-2 pathways in resistance to ErbB-2-targeted therapies in breast cancer von Madera, Santiago, Bulian, Valentina C., Merin, Sharon S., Mercogliano, María F., Schillaci, Roxana, Russo, Rosalia I. Cordo

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Abstract 1195: TNFα induces multiresistance to HER2-targeted TNFα induces multiresistance to HER2-targeted therapies in HER2-positive breast cancer von Mercogliano, María F., Martino, Mara De, Bruni, Sofia, Venturutti, Leandro, Rivas, Martín, Amasino, Matías, Proietti, Cecilia J., Elizalde, Patricia V., Schillaci, Roxana

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Abstract B25: Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy von De Martino, Mara, Tkach, Mercedes, Mercogliano, María F., Cenciarini, Mauro E., Chervo, María F., Proietti, Cecilia J., Elizalde, Patricia V., Piaggio, Eliane, Schillaci, Roxana

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Abstract 1913: Soluble TNFα blockade overcomes lapatinib resistance and induces an innate immune response in HER2-positive breast cancer von Bruni, Sofia, Mauro, Florencia L., De Martino, Mara, Deamicis, Agustina Roldán, Mercogliano, María F., Elizalde, Patricia V., Schillaci, Roxana

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Abstract 712: TNFα-induced MUC4 elicits trastuzumab resistance in ErbB-2-positive breast cancer von Mercogliano, María F., De Martino, Mara, Venturutti, Leandro, Rivas, Martín A., Inurrigarro, Gloria, Frahm, Isabel, Proietti, Cecilia J., Izzo, Franco, Elizalde, Patricia V., Schillaci, Roxana

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Abstract 2265: Stat3 and ErbB-2 interaction in breast cancer metastasis von Venturutti, Leandro, Romero, Lucía V., Urtreger, Alejandro J., Chervo, María F., Mercogliano, María F., Cordo Russo, Rosalía I., Pereyra, Matías G., Inurrigarro, Gloria, Díaz Flaqué, María C., Sunblad, Victoria, Roa, Juan C., Guzmán, Pablo, Bal de Kier-Joffe, Elisa, Charreau, Eduardo H., Schillaci, Roxana, Elizalde, Patricia V.

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