5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint von Donati, Giulio, Peddigari, Suresh, Mercer, Carol A., Thomas, George

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Growth control and ribosomopathies von Teng, Teng, Thomas, George, Mercer, Carol A

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A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy von Mercer, Carol A., Kaliappan, Alagammai, Dennis, Patrick B.

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Mitochondrial Complex I Activity Is Required for Maximal Autophagy von Thomas, Hala Elnakat, Zhang, Yu, Stefely, Jonathan A., Veiga, Sonia R., Thomas, George, Kozma, Sara C., Mercer, Carol A.

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Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity von Teng, Teng, Mercer, Carol A., Hexley, Philip, Thomas, George, Fumagalli, Stefano

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Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology von Zhang, Cai, Seo, Joonbae, Murakami, Kazutoshi, Salem, Esam S. B., Bernhard, Elise, Borra, Vishnupriya J., Choi, Kwangmin, Yuan, Celvie L., Chan, Calvin C., Chen, Xiaoting, Huang, Taosheng, Weirauch, Matthew T., Divanovic, Senad, Qi, Nathan R., Thomas, Hala Einakat, Mercer, Carol A., Siomi, Haruhiko, Nakamura, Takahisa

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Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy von Stefely, Jonathan A., Zhang, Yu, Freiberger, Elyse C., Kwiecien, Nicholas W., Thomas, Hala Elnakat, Davis, Alexander M., Lowry, Nathaniel D., Vincent, Catherine E., Shishkova, Evgenia, Clark, Nicholas A., Medvedovic, Mario, Coon, Joshua J., Pagliarini, David J., Mercer, Carol A.

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Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death von Domostegui, Ana, Peddigari, Suresh, Mercer, Carol A., Iannizzotto, Flavia, Rodriguez, Marta L., Garcia-Cajide, Marta, Amador, Virginia, Diepstraten, Sarah T., Kelly, Gemma L., Salazar, Ramón, Kozma, Sara C., Kusnadi, Eric P., Kang, Jian, Gentilella, Antonio, Pearson, Richard B., Thomas, George, Pelletier, Joffrey

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Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor von McFarland-Mancini, Molly M, Funk, Holly M, Paluch, Andrew M, Zhou, Mingfu, Giridhar, Premkumar Vummidi, Mercer, Carol A, Kozma, Sara C, Drew, Angela F

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Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice von ROBINSON-SMITH, Toni M, ISAACSOHN, Idit, MERCER, Carol A, MINGFU ZHOU, VAN ROOIJEN, Nico, HUSSEINZADEH, Nader, MCFARLAND-MANCINI, Molly M, DREW, Angela F

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A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies von Wise-Draper, Trisha M., Moorthy, Ganesh, Salkeni, Mohamad A., Karim, Nagla Abdel, Thomas, Hala Elnakat, Mercer, Carol A., Beg, M. Shalaan, O’Gara, Sue, Olowokure, Olugbenga, Fathallah, Hassana, Kozma, Sara C., Thomas, George, Rixe, Olivier, Desai, Pankaj, Morris, John C.

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Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR von Veiga, Sónia R, Ge, Xuemei, Mercer, Carol A, Hernández-Álvarez, María I, Thomas, Hala Elnakat, Hernandez-Losa, Javier, Ramón Y Cajal, Santiago, Zorzano, Antonio, Thomas, George, Kozma, Sara C

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mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma von Thomas, Hala Elnakat, Mercer, Carol A, Carnevalli, Larissa S, Park, Jongsun, Andersen, Jesper B, Conner, Elizabeth A, Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J, Manway, Liu, Maira, S. Michel, Thorgeirsson, Snorri S, Mischel, Paul S, Thomas, George, Kozma, Sara C

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mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment von Orr-Asman, Melissa A, Chu, Zhengtao, Jiang, Min, Worley, Mariah, LaSance, Kathleen, Koch, Sheryl E, Carreira, Vinicius S, Dahche, Hanan M, Plas, David R, Komurov, Kakajan, Qi, Xiaoyang, Mercer, Carol A, Anthony, Lowell B, Rubinstein, Jack, Thomas, Hala E

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A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report von Fouladi, Maryam, Perentesis, John P, Wagner, Lars M, Vinks, Alexander A, Reid, Joel M, Ahern, Charlotte, Thomas, George, Mercer, Carol A, Krueger, Darcy A, Houghton, Peter J, Doyle, L Austin, Chen, Helen, Weigel, Brenda, Blaney, Susan M

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Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization von Mercer, Carol A., Kaliappan, Alagammai, Dennis, Patrick B.

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p63 Overexpression Induces the Expression of Sonic Hedgehog von Caserta, Tina M, Kommagani, Ramakrishna, Yuan, Ziqiang, Robbins, David J, Mercer, Carol A, Kadakia, Madhavi P

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Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells von Giridhar, Premkumar Vummidi, Funk, Holly M., Gallo, Catherine A., Porollo, Aleksey, Mercer, Carol A., Plas, David R., Drew, Angela F.

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Abstract 2024: c-Myc driven B cell lymphomas: role of the RPL5/RPL11/5S rRNA-MDM2 inhibitory complex (L5/L11/5S-MIC) von Peddigari, Suresh, Mercer, Carol, Kozma, Sara, Thomas, George

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mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors von Lewis, C. S., Elnakat Thomas, H., Orr‐Asman, M. A., Green, L. C., Boody, R. E., Matiash, K., Karve, A., Hisada, Y. M., Davis, H. W., Qi, X., Mercer, C. A., Lucas, F. V., Aronow, B. J., Mackman, N., Versteeg, H. H., Bogdanov, V. Y.

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