Exciting new tools for studying TREM2 in dementia von Menzies, Georgina E., Torvell, Megan

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Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence von Menzies, Georgina E., Prior, Ian A., Brancale, Andrea, Reed, Simon H., Lewis, Paul D.

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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522 von Maguire, Emily, Menzies, Georgina E, Phillips, Thomas, Sasner, Michael, Williams, Harriet M, Czubala, Magdalena A, Evans, Neil, Cope, Emma L, Sims, Rebecca, Howell, Gareth R, Lloyd‐Evans, Emyr, Williams, Julie, Allen, Nicholas D, Taylor, Philip R

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Glycosylation increases active site rigidity leading to improved enzyme stability and turnover von Ramakrishnan, Krithika, Johnson, Rachel L., Winter, Samuel D., Worthy, Harley L., Thomas, Christopher, Humer, Diana C., Spadiut, Oliver, Hindson, Sarah H., Wells, Stephen, Barratt, Andrew H., Menzies, Georgina E., Pudney, Christopher R., Jones, D. Dafydd

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Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5 von Zelek, Wioleta M., Menzies, Georgina E., Brancale, Andrea, Stockinger, Brigitta, Morgan, Bryan Paul

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Utilizing biological experimental data and molecular dynamics for the classification of mutational hotspots through machine learning von Davies, James G, Menzies, Georgina E

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Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability von Menzies, Georgina E, Reed, Simon H, Brancale, Andrea, Lewis, Paul D

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Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides von Powell, Lydia C., Pritchard, Manon F., Ferguson, Elaine L., Powell, Kate A., Patel, Shree U., Rye, Phil D., Sakellakou, Stavroula-Melina, Buurma, Niklaas J., Brilliant, Charles D., Copping, Jack M., Menzies, Georgina E., Lewis, Paul D., Hill, Katja E., Thomas, David W.

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A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease von Pritchard, Manon F, Powell, Lydia C, Menzies, Georgina E, Lewis, Paul D, Hawkins, Karl, Wright, Chris, Doull, Iolo, Walsh, Timothy R, Onsøyen, Edvar, Dessen, Arne, Myrvold, Rolf, Rye, Philip D, Myrset, Astrid H, Stevens, Howard N. E, Hodges, Lee A, MacGregor, Gordon, Neilly, James B, Hill, Katja E, Thomas, David W

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Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort von Grama, Steluta, Willcocks, Isabella, Hubert, John J., Pardiñas, Antonio F., Legge, Sophie E., Bracher-Smith, Matthew, Menzies, Georgina E., Hall, Lynsey S., Pocklington, Andrew J., Anney, Richard J. L., Bray, Nicholas J., Escott-Price, Valentina, Caseras, Xavier

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Benefits and Challenges of Rare Genetic Variation in Alzheimer’s Disease von Grozeva, Detelina, Saad, Salha, Menzies, Georgina E., Sims, Rebecca

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Fourier transform infrared for noninvasive optical diagnosis of oral, oropharyngeal, and laryngeal cancer von Menzies, Georgina E, Fox, Hannah R, Marnane, Conor, Pope, Laysan, Prabhu, Vinod, Winter, Stuart, Derrick, Anna V, Lewis, Paul D

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MutAIT: an online genetic toxicology data portal and analysis tools von Avancini, Daniele, Menzies, Georgina E, Morgan, Claire, Wills, John, Johnson, George E, White, Paul A, Lewis, Paul D

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MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER’S DISEASE von Menzies, Georgina E., Sims, Rebecca, Williams, Julie

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P1‐245: MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER'S DISEASE von Menzies, Georgina E., Sims, Rebecca, Williams, Julie

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MOLECULAR DYNAMIC MODELLING OF A NOVEL PLCG2 VARIANT REVEALS KEY PROTEIN STRUCTURAL DIFFERENCES von Menzies, Georgina E., Sims, Rebecca, Williams, Julie

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The Alzheimer’s disease protective R522 variant of PLCg2, consistently enhances PLCγ2 activation, depleting PI(4,5)P 2 levels and altering cell function in in vitro and in vivo ass... von Philips, Thomas Ernest James, Maguire, Emily, Menzies, Georgina E, Sasner, Michael, Williams, Harriet M, Czubala, Magdalena, Evans, Neil, Cope, Emma L, Sims, Rebecca, Howell, Gareth, Lloyd‐Evans, Emyr, Williams, Julie, Allen, Nicholas D, Taylor, Philip

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The Alzheimer’s disease protective R522 variant of PLCg2, consistently enhances PLCγ2 activation, depleting PI(4,5)P2 levels and altering cell function in in vitro and in vivo assa... von Philips, Thomas Ernest James, Maguire, Emily, Menzies, Georgina E, Sasner, Michael, Williams, Harriet M, Czubala, Magdalena, Evans, Neil, Cope, Emma L, Sims, Rebecca, Howell, Gareth, Lloyd‐Evans, Emyr, Williams, Julie, Allen, Nicholas D, Taylor, Philip

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O5‐10‐01: ENHANCED FUNCTION OF PLCG2 VARIANT P522R IN MACROPHAGES AND MICROGLIA IS ASSOCIATED WITH PROTECTION FROM ALZHEIMER'S DISEASE von Maguire, Emily, Menzies, Georgina E., James Philips, Thomas Ernest, Cope, Emma L., Czubala, Magdalena, Evans, Neil, Howell, Gareth, Williams, Harriet M., Sasner, Michael, Lloyd-Evans, Emyr, Sims, Rebecca, Williams, Julie, Allen, Nicholas D., Taylor, Philip

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NEXT GENERATION EXOME SEQUENCING IN A LARGE SAMPLE OF ALZHEIMER’S PATIENTS von Grozeva, Detelina, Frizzati, Aura, Sims, Rebecca, Morgan, Taniesha, Raybould, Rachel, Rees, Elliott, Majounie, Elisa, Denning, Nicola, Meggy, Alun, Marshall, Rachel, Beaumont, Bartholomew, Nash, William, Davies, Chloe, Morgan, Joanne, Leonenko, Ganna, Menzies, Georgina E., Badarinarayan, Nandini, Escott-Price, Valentina, Williams, Julie

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