Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified von Debackere, Koen, Marcelis, Lukas, Demeyer, Sofie, Vanden Bempt, Marlies, Mentens, Nicole, Gielen, Olga, Jacobs, Kris, Broux, Michael, Verhoef, Gregor, Michaux, Lucienne, Graux, Carlos, Wlodarska, Iwona, Gaulard, Philippe, de Leval, Laurence, Tousseyn, Thomas, Cools, Jan, Dierickx, Daan

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TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia von Thielemans, Naomi, Demeyer, Sofie, Mentens, Nicole, Gielen, Olga, Provost, Sarah, Cools, Jan

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Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia von Atak, Zeynep Kalender, Gianfelici, Valentina, Hulselmans, Gert, De Keersmaecker, Kim, Devasia, Arun George, Geerdens, Ellen, Mentens, Nicole, Chiaretti, Sabina, Durinck, Kaat, Uyttebroeck, Anne, Vandenberghe, Peter, Wlodarska, Iwona, Cloos, Jacqueline, Foà, Robin, Speleman, Frank, Cools, Jan, Aerts, Stein

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Efficacy of the Kinase Inhibitor SU11248 against Gastrointestinal Stromal Tumor Mutants Refractory to Imatinib Mesylate von PRENEN, Hans, COOLS, Jan, MENTENS, Nicole, FOLENS, Cedric, SCIOT, Raf, SCHÖFFSKI, Patrick, VAN OOSTEROM, Allan, MARYNEN, Peter, DEBIEC-RYCHTER, Maria

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Oncogenic Cooperation Between IL7R‐JAK‐STAT Pathway Mutations von Lodewijckx, Inge, Mentens, Nicole, Jacobs, Kris, Cools, Jan

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Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants von Debiec-Rychter, Maria, Cools, Jan, Dumez, Herlinde, Sciot, Raf, Stul, Michel, Mentens, Nicole, Vranckx, Hilde, Wasag, Bartosz, Prenen, Hans, Roesel, Johannes, Hagemeijer, Anne, Van Oosterom, Allan, Marynen, Peter

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Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK g... von van der Krogt, Jo-Anne, Bempt, Marlies Vanden, Ferreiro, Julio Finalet, Mentens, Nicole, Jacobs, Kris, Pluys, Ursula, Doms, Kathleen, Geerdens, Ellen, Uyttebroeck, Anne, Pierre, Pascal, Michaux, Lucienne, Devos, Timothy, Vandenberghe, Peter, Tousseyn, Thomas, Cools, Jan, Wlodarska, Iwona

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NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins von De Keersmaecker, Kim, Porcu, Michaël, Cox, Luk, Girardi, Tiziana, Vandepoel, Roel, de Beeck, Joyce Op, Gielen, Olga, Mentens, Nicole, Bennett, Keiryn L, Hantschel, Oliver

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The ability of sorafenib to inhibit oncogenic PDGFRβ and FLT3 mutants and overcome resistance to other small molecule inhibitors von LIERMAN, Els, LAHORTIGA, Idoya, VAN MIEGROET, Helen, MENTENS, Nicole, MARYNEN, Peter, COOLS, Jan

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Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent von Stover, Elizabeth H., Chen, Jing, Folens, Cedric, Lee, Benjamin H., Mentens, Nicole, Marynen, Peter, Williams, Ifor R., Gilliland, D. Gary, Cools, Jan

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In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia von DE KEERSMAECKER, Kim, LAHORTIGA, Idoya, MENTONS, Nicole, FOLENS, Cedric, VAN NESTE, Leander, BEKAERT, Sofie, VANDENBERGHE, Peter, ODERO, Maria D, MARYNEN, Peter, COOLS, Jan

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Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor von Cools, Jan, Wlodarska, Iwona, Somers, Riet, Mentens, Nicole, Pedeutour, Florence, Maes, Brigitte, De Wolf-Peeters, Christiane, Pauwels, Patrick, Hagemeijer, Anne, Marynen, Peter

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MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context von KLEPPE, Maria, MENTENS, Nicole, TOUSSEYN, Thomas, WLODARSKA, Iwona, COOLS, Jan

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Intestinal Neurofibromatosis Is a Subtype of Familial GIST and Results From a Dominant Activating Mutation in PDGFRA von de Raedt, Thomas, Cools, Jan, Debiec–Rychter, Maria, Brems, Hilde, Mentens, Nicole, Sciot, Raf, Himpens, Jacques, de Wever, Ivo, Schöffski, Patrick, Marynen, Peter, Legius, Eric

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EML1–ABL1 Is Activated by Coiled‐Coil‐Mediated Oligomerization and Induces T‐Cell Acute Lymphoblastic Leukemia or Myeloproliferative Disease in a Mouse Bone Marrow Transplant Model... von Vanden Bempt, Marlies, Mentens, Nicole, Vandenberghe, Peter, Cools, Jan, De Keersmaecker, Kim

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Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion von Lahortiga, Idoya, Akin, Cem, Cools, Jan, Wilson, Todd M, Mentens, Nicole, Arthur, Diane C, Maric, Irina, Noel, Pierre, Kocabas, Can, Marynen, Peter, Lessin, Lawrence S, Wlodarska, Iwona, Robyn, Jamie, Metcalfe, Dean D

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3023 – CHARACTERIZATION OF THE ONCOGENIC ACTIVITY OF TLX1 AND TLX3 TRANSCRIPTION COMPLEXES IN T-ALL von Veloso, Alexandra Bacquelaine, Lauwereins, Lukas, Demeyer, Sofie, Mentens, Nicole, Boogaerts, Lien, Jacobs, Kris, Cools, Jan

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TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia von Thielemans, Naomi, Demeyer, Sofie, Mentens, Nicole, Gielen, Olga, Provost, Sarah, Cools, Jan

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JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model von Degryse, Sandrine, de Bock, Charles E., Cox, Luk, Demeyer, Sofie, Gielen, Olga, Mentens, Nicole, Jacobs, Kris, Geerdens, Ellen, Gianfelici, Valentina, Hulselmans, Gert, Fiers, Mark, Aerts, Stein, Meijerink, Jules P., Tousseyn, Thomas, Cools, Jan

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Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia von De Keersmaecker, Kim, Atak, Zeynep Kalender, Li, Ning, Vicente, Carmen, Patchett, Stephanie, Girardi, Tiziana, Gianfelici, Valentina, Geerdens, Ellen, Clappier, Emmanuelle, Porcu, Michaël, Lahortiga, Idoya, Lucà, Rossella, Yan, Jiekun, Hulselmans, Gert, Vranckx, Hilde, Vandepoel, Roel, Sweron, Bram, Jacobs, Kris, Mentens, Nicole, Wlodarska, Iwona, Cauwelier, Barbara, Cloos, Jacqueline, Soulier, Jean, Uyttebroeck, Anne, Bagni, Claudia, Hassan, Bassem A, Vandenberghe, Peter, Johnson, Arlen W, Aerts, Stein, Cools, Jan

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