Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'Receptor knock-down' tool von VAN MUIJLWIJK-KOEZEN, Jacqueline E, TIMMERMAN, Henk, VAN DER SLUIS, Richard P, VAN DE STOLPE, Andrea C, MENGE, Wiro M. P. B, BEUKERS, Margot W, VAN DER GRAAF, Piet H, DE GROOTE, Miriam, IJZERMAN, Adriaan P

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New high affinity H3 receptor agonists without a basic side chain von KITBUNNADAJ, Ruengwit, HOFFMANN, Marcel, LEURS, Rob, FRATANTONI, Silvina A, BONGERS, Gerold, BAKKER, Remko A, WIELAND, Kerstin, EL JILALI, Ahmed, DE ESCH, Iwan J. P, MENGE, Wiro M. P. B, TIMMERMAN, Henk

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New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity von van Acker, Frédérique A.A, Hulshof, Janneke W, Haenen, Guido R.M.M, Menge, Wiro M.P.B, van der Vijgh, Wim J.F, Bast, Aalt

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A role for spinal, but not supraspinal, α2 adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic von SVOKOS, Konstantina, NALWALK, Julia W, LEURS, Rob, MENGE, Wiro M. P. B, TIMMERMAN, Henk, HOUGH, Lindsay B

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Synthesis and histamine H3 receptor activity of 4-(n-alkyl)-1H-imidazoles and 4-(ω-phenylalkyl)-1H-imidazoles von DE ESCH, I. J. P, GAFFAR, A, MENGE, W. M. P. B, TIMMERMAN, H

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Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study von Onderwater, Rob C.A, Commandeur, Jan N.M, Groot, Ed J, Sitters, Astrid, Menge, Wiro M.P.B, Vermeulen, Nico P.E

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Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats von Bannoura, Michelle D, Nalwalk, Julia W, Tang, Yuming, Carlile, MaryEllen, Leurs, Rob, Menge, Wiro M.P.B, Timmerman, Henk, Hough, Lindsay B

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Identification of 4-(1H-Imidazol-4(5)-ylmethyl)pyridine (Immethridine) as a Novel, Potent, and Highly Selective Histamine H3 Receptor Agonist von Kitbunnadaj, Ruengwit, Zuiderveld, Obbe P, Christophe, Bernard, Hulscher, Saskia, Menge, Wiro M. P. B, Gelens, Edith, Snip, Erwin, Bakker, Remko A, Celanire, Sylvain, Gillard, Michel, Talaga, Patrice, Timmerman, Henk, Leurs, Rob

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Isoquinoline and Quinazoline Urea Analogues as Antagonists for the Human Adenosine A3 Receptor von van Muijlwijk-Koezen, Jacqueline E, Timmerman, Henk, van der Goot, Henk, Menge, Wiro M. P. B, Frijtag von Drabbe Künzel, Jacobien, de Groote, Miriam, IJzerman, Adriaan P

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N-Substituted Piperidinyl Alkyl Imidazoles:  Discovery of Methimepip as a Potent and Selective Histamine H3 Receptor Agonist von Kitbunnadaj, Ruengwit, Hashimoto, Takeshi, Poli, Enzo, Zuiderveld, Obbe P, Menozzi, Alessandro, Hidaka, Ryoko, de Esch, Iwan J. P, Bakker, Remko A, Menge, Wiro M. P. B, Yamatodani, Atsushi, Coruzzi, Gabriella, Timmerman, Henk, Leurs, Rob

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Synthesis and Structure−Activity Relationship of the First Nonpeptidergic Inverse Agonists for the Human Cytomegalovirus Encoded Chemokine Receptor US28 von Hulshof, Janneke W, Casarosa, Paola, Menge, Wiro M. P. B, Kuusisto, Leena M. S, van der Goot, Henk, Smit, Martine J, de Esch, Iwan J. P, Leurs, Rob

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Synthesis and Structure−Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists von Kitbunnadaj, Ruengwit, Zuiderveld, Obbe P, De Esch, Iwan J. P, Vollinga, Roeland C, Bakker, Remko, Lutz, Martin, Spek, Anthony L, Cavoy, Emile, Deltent, Marie-France, Menge, Wiro M. P. B, Timmerman, Henk, Leurs, Rob

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A Chemical Switch for the Modulation of the Functional Activity of Higher Homologues of Histamine on the Human Histamine H3 Receptor:  Effect of Various Substitutions at the Primar... von Govoni, Marinella, Lim, Herman D., El-Atmioui, Dris, Menge, Wiro M. P. B., Timmerman, Henk, Bakker, Remko A., Leurs, Rob, De Esch, Iwan J. P.

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Synthesis of Novel Se-Substituted Selenocysteine Derivatives as Potential Kidney Selective Prodrugs of Biologically Active Selenol Compounds:  Evaluation of Kinetics of β-Eliminati... von Andreadou, Ioanna, Menge, Wiro M. P. B, Commandeur, Jan N. M, Worthington, Eduard A, Vermeulen, Nico P. E

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New high affinity H 3 receptor agonists without a basic side chain von Kitbunnadaj, Ruengwit, Hoffmann, Marcel, Fratantoni, Silvina A., Bongers, Gerold, Bakker, Remko A., Wieland, Kerstin, Jilali, Ahmed el, De Esch, Iwan J.P., Menge, Wiro M.P.B., Timmerman, Henk, Leurs, Rob

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A New Potent and Selective Histamine H3 Receptor Agonist, 4-(1H-imidazol-4-ylmethyl)piperidine von Vollinga, Roeland C, de Koning, Johannes P, Jansen, Frank P, Leurs, Rob, Menge, Wiro M. P. B, Timmerman, Hendrik

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Evaluation of [ 18 F]VUF 5000 as a potential PET ligand for brain imaging of the histamine H 3 receptor von Windhorst, Albert D., Timmerman, Henk, Klok, Rob P., Menge, Wiro M.P.B., Leurs, Rob, Herscheid, Jacobus D.M.

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Activation of Microsomal Glutathione S-Transferase and Inhibition of Cytochrome P450 1A1 Activity as a Model System for Detecting Protein Alkylation by Thiourea-Containing Compound... von Onderwater, Rob C. A, Commandeur, Jan N. M, Menge, Wiro M. P. B, Vermeulen, Nico P. E

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A Third Life for Burimamide: Discovery and Characterization of a Novel Class of Non-Opioid Analgesics Derived from Histamine Antagonists von HOUGH, LINDSAY B., NALWALK, JULIA W., BARNES, WILLIAM G., LEURS, ROB, MENGE, WIRO M. P. B., TIMMERMAN, HENK, WENTLAND, MARK

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Characterization of the Binding Site of the Histamine H3 Receptor. 2. Synthesis, in Vitro Pharmacology, and QSAR of a Series of Monosubstituted Benzyl Analogues of Thioperamide von Windhorst, Albert D, Timmerman, Henk, Worthington, Edward A, Bijloo, Greetje J, Nederkoorn, Paul H. J, Menge, Wiro M. P. B, Leurs, Rob, Herscheid, Jacobus D. M

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