RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits von Lara Ordónez, Antonio Jesús, Fernández, Belén, Fdez, Elena, Romo-Lozano, María, Madero-Pérez, Jesús, Lobbestael, Evy, Baekelandt, Veerle, Aiastui, Ana, López de Munaín, Adolfo, Melrose, Heather L, Civiero, Laura, Hilfiker, Sabine

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Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons von Schapansky, Jason, Khasnavis, Saurabh, DeAndrade, Mark P., Nardozzi, Jonathan D., Falkson, Samuel R., Boyd, Justin D., Sanderson, John B., Bartels, Tim, Melrose, Heather L., LaVoie, Matthew J.

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LRRK2 and ubiquitination: implications for kinase inhibitor therapy von Melrose, Heather L

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Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain von Liu, Chia-Chen, Hu, Jin, Tsai, Chih-Wei, Yue, Mei, Melrose, Heather L, Kanekiyo, Takahisa, Bu, Guojun

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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors von Hinkle, Kelly M, Yue, Mei, Behrouz, Bahareh, Dächsel, Justus C, Lincoln, Sarah J, Bowles, Erin E, Beevers, Joel E, Dugger, Brittany, Winner, Beate, Prots, Iryna, Kent, Caroline B, Nishioka, Kenya, Lin, Wen-Lang, Dickson, Dennis W, Janus, Christopher J, Farrer, Matthew J, Melrose, Heather L

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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice von Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Nixon-Abell, Jonathon, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heather L, Cookson, Mark R, Harvey, Kirsten

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Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies von Davies, Paul, Hinkle, Kelly M, Sukar, Nour N, Sepulveda, Bryan, Mesias, Roxana, Serrano, Geidy, Alessi, Dario R, Beach, Thomas G, Benson, Deanna L, White, Charles L, Cowell, Rita M, Das, Sonal S, West, Andrew B, Melrose, Heather L

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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents von West, Andrew B., Cowell, Rita M., Daher, João P.L., Moehle, Mark S., Hinkle, Kelly M., Melrose, Heather L., Standaert, David G., Volpicelli-Daley, Laura A.

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VPS35 Mutations in Parkinson Disease von Vilariño-Güell, Carles, Wider, Christian, Ross, Owen A., Dachsel, Justus C., Kachergus, Jennifer M., Lincoln, Sarah J., Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., Wilhoite, Greggory J., Bacon, Justin A., Behrouz, Bahareh, Melrose, Heather L., Hentati, Emna, Puschmann, Andreas, Evans, Daniel M., Conibear, Elizabeth, Wasserman, Wyeth W., Aasly, Jan O., Burkhard, Pierre R., Djaldetti, Ruth, Ghika, Joseph, Hentati, Faycal, Krygowska-Wajs, Anna, Lynch, Tim, Melamed, Eldad, Rajput, Alex, Rajput, Ali H., Solida, Alessandra, Wu, Ruey-Meei, Uitti, Ryan J., Wszolek, Zbigniew K., Vingerhoets, François, Farrer, Matthew J.

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Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson’s Disease von Massaquoi, Michelle S., Liguore, William A., Churchill, Madeline J., Moore, Cindy, Melrose, Heather L., Meshul, Charles K.

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Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia von Maekawa, Tatsunori, Sasaoka, Toshikuni, Azuma, Sadahiro, Ichikawa, Takafumi, Melrose, Heather L, Farrer, Matthew J, Obata, Fumiya

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ER stress response plays an important role in aggregation of α-synuclein von Jiang, Peizhou, Gan, Ming, Ebrahim, Abdul Shukkur, Lin, Wen-Lang, Melrose, Heather L, Yen, Shu-Hui C

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LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory von Beccano-Kelly, Dayne A, Volta, Mattia, Munsie, Lise N, Paschall, Sarah A, Tatarnikov, Igor, Co, Kimberley, Chou, Patrick, Cao, Li-Ping, Bergeron, Sabrina, Mitchell, Emma, Han, Heather, Melrose, Heather L, Tapia, Lucia, Raymond, Lynn A, Farrer, Matthew J, Milnerwood, Austen J

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Mechanisms of Adiponectin-Associated Perivascular Function in Vascular Disease von Withers, Sarah B, Bussey, Charlotte E, Saxton, Sophie N, Melrose, Heather M, Watkins, Amy E, Heagerty, Anthony M

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Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology von Hou, Xu, Watzlawik, Jens O., Cook, Casey, Liu, Chia‐Chen, Kang, Silvia S., Lin, Wen‐Lang, DeTure, Michael, Heckman, Michael G., Diehl, Nancy N., Al‐Shaikh, Fadi S. Hanna, Walton, Ronald L., Ross, Owen A., Melrose, Heather L., Ertekin‐Taner, Nilüfer, Bu, Guojun, Petrucelli, Leonard, Fryer, John D., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter

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LRRK2 phosphorylates novel tau epitopes and promotes tauopathy von Bailey, Rachel M., Covy, Jason P., Melrose, Heather L., Rousseau, Linda, Watkinson, Ruth, Knight, Joshua, Miles, Sarah, Farrer, Matthew J., Dickson, Dennis W., Giasson, Benoit I., Lewis, Jada

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Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice von Volta, Mattia, Beccano-Kelly, Dayne A, Paschall, Sarah A, Cataldi, Stefano, MacIsaac, Sarah E, Kuhlmann, Naila, Kadgien, Chelsie A, Tatarnikov, Igor, Fox, Jesse, Khinda, Jaskaran, Mitchell, Emma, Bergeron, Sabrina, Melrose, Heather, Farrer, Matthew J, Milnerwood, Austen J

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Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice von Adeosun, Samuel O., Hou, Xu, Zheng, Baoying, Melrose, Heather L., Mosley, Thomas, Wang, Jun Ming

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Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses von Kubo, Makoto, Nagashima, Ryuichi, Ohta, Etsuro, Maekawa, Tatsunori, Isobe, Yumiko, Kurihara, Mitsue, Eshima, Koji, Iwabuchi, Kazuya, Sasaoka, Toshikuni, Azuma, Sadahiro, Melrose, Heather L, Farrer, Matthew J, Obata, Fumiya

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Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity von Kluss, Jillian H., Conti, Melissa M., Kaganovich, Alice, Beilina, Aleksandra, Melrose, Heather L., Cookson, Mark R., Mamais, Adamantios

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