TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease von Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Vilar-Pereira, Glaucia, Degrave, Wim, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, da Cruz Moreira, Otacílio, da Silva Gomes, Natália Lins, Mello de Souza, Elen, Ramos, Isalira P, Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C, Waghabi, Mariana Caldas

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CRISPR/Cas-9 vector system: targets UL-39 and inhibits Simplexvirus humanalpha1 (HSV-1) replication in vitro von Jéssica Vasques Raposo, Luciana Rodrigues Carvalho Barros, Lauana Ribas Torres, Rafaela Barbosa da Silva Pinto, Amanda de Oliveira Lopes, Elen Mello de Souza, Martin Hernan Bonamino, Vanessa Salete de Paula

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Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology... von XIAOHUA ZHU, QIANG LIU, STEPHENS, Chad E, BANERJEE, Moloy, FARAHAT, Abdelbasset A, MUNDE, Manoj, DAVID WILSON, W, BOYKIN, David W, ZHUO WANG, Michael, WERBOVETZ, Karl A, SIHYUNG YANG, PARMAN, Toufan, GREEN, Carol E, MIRSALIS, Jon C, DE NAZARE CORREIA SOEIRO, Maria, DE SOUZA, Elen Mello, DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise

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Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection von Nisimura, Lindice Mitie, Ferreira, Roberto Rodrigues, Coelho, Laura Lacerda, Souza, Elen Mello de, Gonzaga, Beatriz Matheus, Ferrão, Patrícia Mello, Waghabi, Mariana Caldas, Mesquita, Liliane Batista de, Pereira, Mirian Claudia de Souza, Moreira, Otacilio da Cruz, Lannes-Vieira, Joseli, Garzoni, Luciana Ribeiro

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Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages von Teixeira, Gabrielly Sbano, Andrade, Audrien Alves, Torres, Lauana Ribas, Couto‐Lima, Dinair, Moreira, Otacilio C., Abreu, Rayane, Waghabi, Mariana Caldas, de Souza, Elen Mello

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P- 1 DEVELOPMENT OF LENTIVIRAL VECTORS FOR INHIBITION OF HEPATITIS B VIRUS, VIA SMALL INTERFERING RNA von Paula, Giovana Angelice, Roque, Pedro Henrique da Conceição, Pereira, Rafaela de Sousa Moraes, de Paula, Vanessa Salete, Lima, Fábio Luís Monteiro, Correia, Lendel da Costa, Tanuri, Amilcar, Mello, Elen de Souza, Melo, Livia Villar, Lampe, Elisabeth, do Amaral, Francisco Mello Campello, Vieira, Bárbara do Lago

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Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease von Waghabi, Mariana Caldas, Ferreira, Roberto Rodrigues, Abreu, Rayane da Silva, Degrave, Wim, de Souza, Elen Mello, Bailly, Sabine, Feige, Jean-Jacques, de Araújo-Jorge, Tania C

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In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi von DE NAZARE CORREIA SOEIRO, Maria, DE SOUZA, Elen Mello, BRITTO, Constança, KWANGHO KIM, SULIKOWSKI, Gary, HARGROVE, Tatiana Y, WATERMAN, Michael R, LEPESHEVA, Galina I, DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise, BATISTA, Marcos Meuser, PAVAO, Beatriz Philot, ARAUJO, Julianna Siciliano, AIUB, Claudia Alessandra Fortes, DA SILVA, Patricia Bernardino, LIONEL, Jessica

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Structural investigation of C6/36 and Vero cell cultures infected with a Brazilian Zika virus von Barreto-Vieira, Debora Ferreira, Jácome, Fernanda Cunha, da Silva, Marcos Alexandre Nunes, Caldas, Gabriela Cardoso, de Filippis, Ana Maria Bispo, de Sequeira, Patrícia Carvalho, de Souza, Elen Mello, Andrade, Audrien Alves, Manso, Pedro Paulo de Abreu, Trindade, Gisela Freitas, Lima, Sheila Maria Barbosa, Barth, Ortrud Monika

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In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance von Ferreira, Roberto Rodrigues, de Souza, Elen Mello, Vilar-Pereira, Glaucia, Degrave, Wim M S, Abreu, Rayane da Silva, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, Ledbeter, Steve, Barker, Robert H, Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C, Waghabi, Mariana Caldas

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Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells von de Souza, Audrien Alves Andrade, Torres, Lauana Ribas, Capobianco, Lyana Rodrigues Pinto Lima, de Paula, Vanessa Salete, Cascabulho, Cynthia Machado, Salomao, Kelly, Bonecini-Almeida, Maria da Gloria, Ferreira, Maria de Lourdes Garcia, Boechat, Nubia, Pinheiro, Luiz Carlos da Silva, de Souza, Elen Mello

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Activities of Psilostachyin A and Cynaropicrin against Trypanosoma cruzi In Vitro and In Vivo von DA SILVA, Cristiane França, DA GAMA JAEN BATISTA, Denise, ZIMMERMANN, Stefanie, HAMBURGER, Matthias, BRUN, Reto, SCHÜHLY, Wolfgang, DE NAZARE CORREIA SOEIRO, Maria, DE ARAUJO, Julianna Siciliano, BATISTA, Marcos Meuser, LIONEL, Jessica, DE SOUZA, Elen Mello, HAMMER, Erica Ripoll, DA SILVA, Patricia Bernardino, DE MIERI, Maria, ADAMS, Michael

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Acute Chagas disease induces cerebral microvasculopathy in mice von Nisimura, Lindice Mitie, Estato, Vanessa, de Souza, Elen Mello, Reis, Patricia A, Lessa, Marcos Adriano, Castro-Faria-Neto, Hugo Caire, Pereira, Mirian Claudia de Souza, Tibiriçá, Eduardo, Garzoni, Luciana Ribeiro

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Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro von Pacheco, Michele Gabriele de Oliveira, Silva, Cristiane França da, Souza, Elen Mello de, Batista, Marcos Meuser, Silva, Patrícia Bernardino da, Kumar, Arvind, Stephens, Chad E., Boykin, David W., Soeiro, Maria de Nazaré C.

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In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection von da Silva, Cristiane França, Batista, Denise da Gama Jaen, Oliveira, Gabriel Melo, de Souza, Elen Mello, Hammer, Erica Ripoll, da Silva, Patricia Bernardino, Daliry, Anissa, Araujo, Julianna Siciliano, Britto, Constança, Rodrigues, Ana Carolina Mondaine, Liu, Zongying, Farahat, Abdelbasset A, Kumar, Arvind, Boykin, David W, Soeiro, Maria de Nazaré Correia

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In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi von DA SILVA, Cristiane Franca, BATISTA, Marcos Meuser, JAEN BATISTA, Denise Da Gama, DE SOUZA, Elen Mello, DA SILVA, Patricia Bernardino, DE OLIVEIRA, Gabriel Melo, MEUSER, Andrea Souza, SHAREEF, Abdur-Rafay, BOYKIN, David W, SOEIRO, Maria De Nazare C

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In Vitro Measurement of Enzymatic Markers as a Tool to Detect Mouse Cardiomyocytes Injury von Souza, Elen Mello de, Henriques-Pons, Andrea, Bailly, Christian, Lansiaux, Amelie, Araújo-Jorge, Tânia Cremonine, Soeiro, Maria de Nazaré Correia

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Activity of “reversed” diamidines against Trypanosoma cruzi “ in vitro” von Silva, C.F., Batista, Marcos Meuser, Mota, Renata Alves, de Souza, Elen Mello, Stephens, Chad E., Som, Phanneth, Boykin, David Wilson, Soeiro, Maria de Nazaré C.

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ZIKV replication is differential in explants and cells of human placental which is suppressed by HSV-2 coinfection von Torres, Lauana Ribas, Capobianco, Lyana Rodrigues Pinto Lima, de Souza, Audrien Alves Andrade, de Almeida Ribeiro, Camilla Rodrigues, Cascabulho, Cynthia, Garzoni, Luciana Ribeiro, Portari, Elyzabeth Avvad, Gardel, Marcelo Aranha, Meuser-Batista, Marcelo, de Paula, Vanessa Salete, de Souza, Elen Mello

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Proteins involved on TGF-β pathway are up-regulated during the acute phase of experimental Chagas disease von Ferreira, Roberto Rodrigues, de Souza, Elen Mello, de Oliveira, Fabiane Loiola, Ferrão, Patrícia Mello, Gomes, Leonardo Henrique Ferreira, Mendonça-Lima, Leila, Meuser-Batista, Marcelo, Bailly, Sabine, Feige, Jean Jacques, de Araujo-Jorge, Tania Cremonini, Waghabi, Mariana Caldas

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