Exploring the relationships between protein sequence, structure and solubility von Trainor, Kyle, Broom, Aron, Meiering, Elizabeth M

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Computational Modeling of Protein Stability: Quantitative Analysis Reveals Solutions to Pervasive Problems von Broom, Aron, Trainor, Kyle, Jacobi, Zachary, Meiering, Elizabeth M.

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Effects of maturation on the conformational free-energy landscape of SOD1 von Culik, Robert M., Sekhar, Ashok, Nagesh, Jayashree, Deol, Harmeen, Rumfeldt, Jessica A. O., Meiering, Elizabeth M., Kay, Lewis E.

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Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy von Sekhar, Ashok, Rumfeldt, Jessica A. O., Broom, Helen R., Doyle, Colleen M., Sobering, Ryan E., Meiering, Elizabeth M., Kay, Lewis E.

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Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways von Sekhar, Ashok, Rumfeldt, Jessica A O, Broom, Helen R, Doyle, Colleen M, Bouvignies, Guillaume, Meiering, Elizabeth M, Kay, Lewis E

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Designed protein reveals structural determinants of extreme kinetic stability von Broom, Aron, Ma, S. Martha, Xia, Ke, Rafalia, Hitesh, Trainor, Kyle, Colón, Wilfredo, Gosavi, Shachi, Meiering, Elizabeth M.

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Computational tools help improve protein stability but with a solubility tradeoff von Broom, Aron, Jacobi, Zachary, Trainor, Kyle, Meiering, Elizabeth M.

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Destabilization of the dimer interface is a common consequence of diverse ALS‐associated mutations in metal free SOD1 von Broom, Helen R., Rumfeldt, Jessica A. O., Vassall, Kenrick A., Meiering, Elizabeth M.

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Modular Evolution and the Origins of Symmetry: Reconstruction of a Three-Fold Symmetric Globular Protein von Broom, Aron, Doxey, Andrew C., Lobsanov, Yuri D., Berthin, Lisa G., Rose, David R., Howell, P. Lynne, McConkey, Brendan J., Meiering, Elizabeth M.

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Concurrent Increases and Decreases in Local Stability and Conformational Heterogeneity in Cu, Zn Superoxide Dismutase Variants Revealed by Temperature-Dependence of Amide Chemical... von Doyle, Colleen M, Rumfeldt, Jessica A, Broom, Helen R, Sekhar, Ashok, Kay, Lewis E, Meiering, Elizabeth M

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Decreased stability and increased formation of soluble aggregates by immature superoxide dismutase do not account for disease severity in ALS von Vassall, Kenrick A., Stubbs, Helen R., Primmer, Heather A., Tong, Ming Sze, Sullivan, Sarah M., Sobering, Ryan, Srinivasan, Saipraveen, Briere, Lee-Ann K., Dunn, Stanley D., Colón, Wilfredo, Meiering, Elizabeth M., Fersht, Alan R.

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Engineering the kinetic stability of a β-trefoil protein by tuning its topological complexity von Anderson, Delaney M, Jayanthi, Lakshmi P, Gosavi, Shachi, Meiering, Elizabeth M

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Cu/Zn Superoxide Dismutase Mutants Associated with Amyotrophic Lateral Sclerosis Show Enhanced Formation of Aggregates in vitro von Stathopulos, P. B., Rumfeldt, J. A. O., Scholz, G. A., Irani, R. A., Frey, H. E., Hallewell, R. A., Lepock, J. R., Meiering, E. M.

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Conformational stability and folding mechanisms of dimeric proteins von Rumfeldt, Jessica A.O., Galvagnion, Céline, Vassall, Kenrick A., Meiering, Elizabeth M.

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Combined Isothermal Titration and Differential Scanning Calorimetry Define Three-State Thermodynamics of fALS-Associated Mutant Apo SOD1 Dimers and an Increased Population of Folde... von Broom, Helen R, Vassall, Kenrick A, Rumfeldt, Jessica A. O, Doyle, Colleen M, Tong, Ming Sze, Bonner, Julia M, Meiering, Elizabeth M

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Sonication of proteins causes formation of aggregates that resemble amyloid von Stathopulos, Peter B., Scholz, Guenter A., Hwang, Young‐Mi, Rumfeldt, Jessica A.O., Lepock, James R., Meiering, Elizabeth M.

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The threat of instability: neurodegeneration predicted by protein destabilization and aggregation propensity von Meiering, Elizabeth M

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Mechanism and Thermodynamics of Guanidinium Chloride-induced Denaturation of ALS-associated Mutant Cu,Zn Superoxide Dismutases von Rumfeldt, Jessica A.O., Stathopulos, Peter B., Chakrabarrty, Avijit, Lepock, James R., Meiering, Elizabeth M.

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Methodological advances and strategies for high resolution structure determination of cellular protein aggregates von Schaefer, Anna, Naser, Dalia, Siebeneichler, Bruna, Tarasca, Michael V., Meiering, Elizabeth M.

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Insight into the Autosomal-Dominant Inheritance Pattern of SOD1-Associated ALS from Native Mass Spectrometry von Cveticanin, Jelena, Mondal, Tridib, Meiering, Elizabeth M., Sharon, Michal, Horovitz, Amnon

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