Myelodysplasia is in the niche: novel concepts and emerging therapies von Bulycheva, E, Rauner, M, Medyouf, H, Theurl, I, Bornhäuser, M, Hofbauer, L C, Platzbecker, U

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Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial von Kubasch, A. S., Peterlin, P., Cluzeau, T., Götze, K. S., Sockel, K., Teipel, R., Jentzsch, M., Attalah, H., Sebert, M., Chermat, F., Gloaguen, S., Puttrich, M., Cross, M., Schneider, M., Kayser, S., Schipp, D., Giagounidis, A., Tirado-Gonzalez, I., Descot, A., van de Loosdrecht, A., Weigert, A., Metzeler, K. H., Fenaux, P., Medyouf, H., Platzbecker, U., Ades, L.

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Correction: CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC von Tirado-Gonzalez, I., Czlonka, E., Nevmerzhitskaya, A., Soetopo, D., Bergonzani, E., Mahmoud, A., Contreras, A., Jeremias, I., Platzbecker, U., Bourquin, J. P., Kloz, U., Van der Hoeven, F., Medyouf, H.

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The identification of the AXL/Gas6 signalling axis as a key player of myelodysplastic syndrome (MDS) and the potential of the oral selective AXL inhibitor bemcentinib in the treatm... von Medyouf, H., Tirado-Gonzalez, I., Mies, A., Nevmerzhitskaya, A., Kubasch, A.-S., Platzbecker, U.

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CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC von Tirado-Gonzalez, I, Czlonka, E, Nevmerzhitskaya, A, Soetopo, D, Bergonzani, E, Mahmoud, A, Contreras, A, Jeremias, I, Platzbecker, U, Bourquin, J P, Kloz, U, Van der Hoeven, F, Medyouf, H

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84: Mesenchymal and MDS stem cells shape an interactive disease unit in the bone marrow von Trumpp, A, Medyouf, H, Hofmann, W.K, Nowak, D

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Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis von JOLIOT, V, CORMIER, F, MEDYOUF, H, ALCALDE, H, GHYSDAEL, J

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156 A NOVEL PCR-BASED ASSAY FOR TARGETED QUANTIFICATION OF DEL(5Q) IN MYELODYSPLASTIC SYNDROMES von Jann, J.C, Nowak, D, Nolte, F, Fey, S, Nowak, V, Obländer, J, Pressler, J, Fabarius, A, Haferlach, C, Medyouf, H, Hofmann, W.K, Mossner, M

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65 MYELODYSPLASTIC SYNDROMES ARE CHARACTERIZED BY RECURRENT PATTERNS IN PATIENT-INDIVIDUAL MUTATIONAL HIERARCHIES THAT ARE SUBJECT TO HIGHLY DYNAMIC SUBCLONAL EVOLUTION DURING THER... von Mossner, M, Jann, J.C, Wittig, J, Nolte, F, Fey, S, Nowak, V, Obländer, J, Pressler, J, Müdder, K, Klein, C, Zens, B, Platzbecker, U, Schönefeldt, C, Fabarius, A, Blum, H, Schulze, T.J, Haferlach, C, Trumpp, A, Hofmann, W.K, Medyouf, H, Nowak, D

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Optimized gene transfer into human primary leukemic T cell with NOD-SCID leukemia-initiating cell activity von Gerby, B, Armstrong, F, de la Grange, P B, Medyouf, H, Calvo, J, Verhoeyen, E, Cosset, F L, Bernstein, I, Amselem, S, Boissel, N, Dombret, H, Leblanc, T, Baruchel, A, Landman-Parker, J, Ballerini, P, Pflumio, F

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O-013 Mesenchymal stromal cells support significant engraftment of low-risk myelodysplastic syndromes (MDS) in a murine xenograft model von Medyouf, H, Mossner, M, Nolte, F, Jann, J.C, Nowak, V, Zens, B, Müdder, K, Oblaender, J, Fey, S, Fabarius, A, Riedl, E, Marx, A, Roehl, H, Mueller, N, Metzgeroth, G, Hütter, G, Hofmann, W.K, Trumpp, A, Nowak, D

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1009PDThe identification of the AXL/Gas6 signalling axis as a key player of myelodysplastic syndrome (MDS) and the potential of the oral selective AXL inhibitor bemcentinib in the... von Medyouf, H, Tirado-Gonzalez, I, Mies, A, Nevmerzhitskaya, A, Kubasch, A-S, Platzbecker, U

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CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC (vol 32, pg 1048, 2018) von Tirado-Gonzalez, I., Czlonka, E., Nevmerzhitskaya, A., Soetopo, D., Bergonzani, E., Mahmoud, A., Contreras, A., Jeremias, I., Platzbecker, U., Bourquin, J. P., Kloz, U., Van der Hoeven, F., Medyouf, H.

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Generation of prostate basal stem cell lines from transgenic mice - proof of principle of inducible ex vivo gene deletion von Höfner, T., Klein, C., Medyouf, H., Sprick, M., Haferkamp, A.

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56 - Generation of prostate basal stem cell lines from transgenic mice - proof of principle of inducible ex vivo gene deletion von Höfner, T., Klein, C., Medyouf, H., Sprick, M., Haferkamp, A.

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Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids von Michels, Birgitta E., Mosa, Mohammed H., Streibl, Barbara I., Zhan, Tianzuo, Menche, Constantin, Abou-El-Ardat, Khalil, Darvishi, Tahmineh, Członka, Ewelina, Wagner, Sebastian, Winter, Jan, Medyouf, Hind, Boutros, Michael, Farin, Henner F.

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Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure von Mossner, Maximilian, Jann, Johann-Christoph, Wittig, Janina, Nolte, Florian, Fey, Stephanie, Nowak, Verena, Obländer, Julia, Pressler, Jovita, Palme, Iris, Xanthopoulos, Christina, Boch, Tobias, Metzgeroth, Georgia, Röhl, Henning, Witt, Stephanie H., Dukal, Helene, Klein, Corinna, Schmitt, Steffen, Gelß, Patrick, Platzbecker, Uwe, Balaian, Ekaterina, Fabarius, Alice, Blum, Helmut, Schulze, Torsten J., Meggendorfer, Manja, Haferlach, Claudia, Trumpp, Andreas, Hofmann, Wolf-Karsten, Medyouf, Hind, Nowak, Daniel

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Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche von Winter, Susann, Götze, Katharina S., Hecker, Judith S., Metzeler, Klaus H., Guezguez, Borhane, Woods, Kevin, Medyouf, Hind, Schäffer, Alexander, Schmitz, Marc, Wehner, Rebekka, Glauche, Ingmar, Roeder, Ingo, Rauner, Martina, Hofbauer, Lorenz C., Platzbecker, Uwe

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Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDS von Schaeffer, Alexander, Czlonka, Ewelina, Tirado-González, Irene, Böse, Thomas, Beauvarlet, Jennifer, Kur, Ivan, Bözec, Aline, Bönig, Halvard, Brandts, Christian H., Platzbecker, Uwe, Götze, Katharina S., Medyouf, Hind

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PB1715: UNLEASHING NATURAL KILLER (NK) CELLS TO PROMOTE ANTI‐LEUKEMIC IMMUNITY von Tsoukala, Ioanna, Schäffer, Alexander, Tirado‐Gonzalez, Irene, Röder, Jasmin, Serrahima, Jordi Pfeifer, Mosa, Mohammed H., Seotopo, Devona, Descot, Arnaud, Wels, Winfried S., Medyouf, Hind

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