6000 Aspirin prevents cancer in Lynch syndrome von Burn, J, Gerdes, A.M, Mecklin, J.P, Macrae, F, Moeslein, G, Bisgaard, M.L, Ramesar, R, Eccles, D.T, Mathers, J.C, Bishop, D.T

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Clues to the Pathogenesis of Familial Colorectal Cancer von Aaltonen, Lauri A., Peltomäki, Päivi, Leach, Fredrick S., Sistonen, Pertti, Pylkkänen, Lea, Mecklin, Jukka-Pekka, Järvinen, Heikki, Powell, Steven M., Jen, Jin, Hamilton, Stanley R., Petersen, Gloria M., Kinzler, Kenneth W., Vogelstein, Bert, de la Chapelle, Albert

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Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer von Peltomäki, Päivi, Aaltonen, Lauri A., Sistonen, Pertti, Pylkkänen, Lea, Mecklin, Jukka-Pekka, Järvinen, Heikki, Green, Jane S., Jass, Jeremy R., Weber, James L., Leach, Fredrick S., Petersen, Gloria M., Hamilton, Stanley R., de la Chapelle, Albert, Vogelstein, Bert

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PO-350 MiRNAs and their relation to biological pathways in left- and right-sided colorectal cancer von Sundaramoorthy, S, Heikkinen, S, Hartikainen, JM, Kuopio, T, Mecklin, JP, Kosma, VM, Mannermaa, A

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The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer von Watson, Patrice, Vasen, Hans F.A., Mecklin, J.P., Järvinen, Heikki, Lynch, Henry T.

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The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution von Ballhausen, A., Przybilla, M.J., Jendrusch, M., Haupt, S., Pfaffendorf, E., Seidler, F., Witt, J., Hernandez Sanchez, A., Urban, K., Draxlbauer, M., Krausert, S., Ahadova, A., Kalteis, M.S., Pfuderer, P.L., Heid, D., Stichel, D., Gebert, J., Bonsack, M., Schott, S., Blaker, H., Seppala, T., Mecklin, J.P., Broeke, S. ten, Nielsen, M., Heuveline, V., Krzykalla, J., Benner, A., Riemer, A.B., Knebel Doeberitz, M. von, Kloor, M.

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The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance von Ahadova, A., Seppala, T.T., Engel, C., Gallon, R., Burn, J., Holinski-Feder, E., Steinke-Lange, V., Moslein, G., Nielsen, M., Broeke, S.W. ten, Laghi, L., Dominguez-Valentin, M., Capella, G., Macrae, F., Scott, R., Huneburg, R., Nattermann, J., Hoffmeister, M., Brenner, H., Blaker, H., Doeberitz, M.V., Sampson, J.R., Vasen, H., Mecklin, J.P., Moller, P., Kloor, M.

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No difference in penetrance between truncating and missense/aberrant splicing pathogenic variants in MLH1 and MSH2: a prospective Lynch syndrome database study von Dominguez-Valentin, M., Plazzer, J.P., Sampson, J.R., Engel, C., Aretz, S., Jenkins, M.A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Macrae, F., Winship, I.M., Thomas, H., Evans, D.G., Burn, J., Greenblatt, M., Cappel, W.H.D.T.N., Sijmons, R.H., Nielsen, M., Bertario, L., Bonanni, B., Tibiletti, M.G., Cavestro, G.M., Lindblom, A., Valle, A. della, Lopez-Kostner, F., Alvarez, K., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C.A., Nakken, S., Hovig, E., Green, K., Lalloo, F., Hill, J., Vasen, H.F.A., Perne, C., Buttner, R., Gorgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Huneburg, R., Doeberitz, M.V., Loeffler, M., Rahner, N., Weitz, J., Steinke-Lange, V., Schmiegel, W., Vangala, D., Crosbie, E.J., Pineda, M., Navarro, M., Brunet, J., Moreira, L., Sanchez, A., Serra-Burriel, M., Mints, M., Kariv, R., Rosner, G., Pinero, T.A., Pavicic, W.H., Kalfayan, P., Broeke, S.W. ten, Mecklin, J.P., Pylvanainen, K., Renkonen-Sinisalo, L., Lepisto, A., Peltomaki, P., Hopper, J.L., Win, A.K., Buchanan, D.D., Lindor, N.M., Gallinger, S., Marchand, L. le, Newcomb, P.A., Figueiredo, J.C., Thibodeau, S.N., Therkildsen, C., Hansen, T.V.O., Lindberg, L., Rodland, E.A., Neffa, F., Esperon, P., Tjandra, D., Moslein, G., Seppala, T.T., Moller, P.

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Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database von Dominguez-Valentin, M., Seppala, T.T., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Hovig, E., Nielsen, M., Sijmons, R.H., Bertario, L., Bonanni, B., Tibiletti, M.G., Cavestro, G.M., Mints, M., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C.A., Green, K., Lalloo, F., Hill, J., Schmiegel, W., Vangala, D., Perne, C., Strauss, H.G., Tecklenburg, J., Holinski-Feder, E., Steinke-Lange, V., Mecklin, J.P., Plazzer, J.P., Pineda, M., Navarro, M., Vidal, J.B., Kariv, R., Rosner, G., Pinero, T.A., Gonzalez, M.L., Kalfayan, P., Sampson, J.R., Ryan, N.A.J., Evans, D.G., Moller, P., Crosbie, E.J.

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Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database von Dominguez-Valentin, M., Seppälä, T.T., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Hovig, E., Nielsen, M., Sijmons, R.H., Bertario, L., Bonanni, B., Tibiletti, M.G., Cavestro, G.M., Mints, M., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C.A., Green, K., Lalloo, F., Hill, J., Schmiegel, W., Vangala, D., Perne, C., Strauss, H.G., Tecklenburg, J., Holinski-Feder, E., Steinke-Lange, V., Mecklin, J.P., Plazzer, J.P., Pineda, M., Navarro, M., Vidal, J.B., Kariv, R., Rosner, G., Piñero, T.A., Gonzalez, M.L., Kalfayan, P., Sampson, J.R., Ryan, N.A.J., Evans, D.G., Moller, P., Crosbie, E.J.

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Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report von Seppala, T.T., Dominguez-Valentin, M., Crosbie, E.J., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Hovig, E., Nielsen, M., Sijmons, R.H., Bertario, L., Bonanni, B., Tibiletti, M.G., Cavestro, G.M., Mints, M., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C.A., Green, K., Lalloo, F., Hill, J., Schmiegel, W., Vangala, D., Perne, C., Strauss, H.G., Tecklenburg, J., Holinski-Feder, E., Steinke-Lange, V., Mecklin, J.P., Plazzer, J.P., Pineda, M., Navarro, M., Vida, J.B., Kariv, R., Rosner, G., Pinero, T.A., Pavicic, W., Kalfayan, P., Broeke, S.W. ten, Jenkins, M.A., Sunde, L., Bernstein, I., Burn, J., Greenblatt, M., Cappel, W.H.D.T.N., Valle, A. della, Lopez-Koestner, F., Alvarez, K., Buttner, R., Gorgens, H., Morak, M., Holzapfel, S., Huneburg, R., Doeberitz, M.V., Loeffler, M., Redler, S., Weitz, J., Pylvanainen, K., Renkonen-Sinisalo, L., Lepisto, A., Hopper, J.L., Win, A.K., Lindor, N.M., Gallinger, S., Marchand, L.L., Newcomb, P.A., Figueiredo, J.C., Thibodeau, S.N., Therkildsen, C., Wadt, K.A.W., Mourits, M.J.E., Ketabi, Z., Denton, O.G., Rodland, E.A., Vasen, H., Neffa, F., Esperon, P., Tjandra, D., Moslein, G., Rokkones, E., Sampson, J.R., Evans, D.G., Moller, P.

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Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report von Dominguez-Valentin, M., Crosbie, E.J., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Nakken, S., Hovig, E., Nielsen, M., Sijmons, R.H., Bertario, L., Bonanni, B., Tibiletti, M.G., Cavestro, G.M., Mints, M., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C.A., Green, K., Lalloo, F., Hill, J., Schmiegel, W., Vangala, D., Perne, C., Strauss, H.G., Tecklenburg, J., Holinski-Feder, E., Steinke-Lange, V., Mecklin, J.P., Plazzer, J.P., Pineda, M., Navarro, M., Vidal, J.B., Kariv, R., Rosner, G., Pinero, T.A., Gonzalez, M.L., Kalfayan, P., Ryan, N., Broeke, S.W. ten, Jenkins, M.A., Sunde, L., Bernstein, I., Burn, J., Greenblatt, M., Cappel, W.H.D.T.N., Valle, A. della, Lopez-Koestner, F., Alvarez, K., Buttner, R., Gorgens, H., Morak, M., Holzapfel, S., Huneburg, R., Doeberitz, M.V., Loeffler, M., Rahner, N., Weitz, J., Pylvanainen, K., Renkonen-Sinisalo, L., Lepisto, A., Auranen, A., Hopper, J.L., Win, A.K., Haile, R.W., Lindor, N.M., Gallinger, S., Marchand, L. le, Newcomb, P.A., Figueiredo, J.C., Thibodeau, S.N., Therkildsen, C., Okkels, H., Ketabi, Z., Denton, O.G., Rodland, E.A., Vasen, H., Neffa, F., Esperon, P., Tjandra, D., Moslein, G., Sampson, J.R., Evans, D.G., Seppala, T.T., Moller, P.

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Associations of pathogenic variants in MLH1, MSH2, and MSH6 with risk of colorectal adenomas and tumors and with somatic mutations in patients with Lynch syndrome von Engel, C., Ahadova, A., Seppala, T.T., Aretz, S., Bigirwamungu-Bargeman, M., Blaker, H., Bucksch, K., Buttner, R., Cappel, W.T.D.T., Endris, V., Holinski-Feder, E., Holzapfel, S., Huneburg, R., Jacobs, M.A.J.M., Koornstra, J.J., Langers, A.M., Lepisto, A., Morak, M., Moslein, G., Peltomaki, P., Pylvanainen, K., Rahner, N., Renkonen-Sinisalo, L., Schulmann, K., Steinke-Lange, V., Stenzinger, A., Strassburg, C.P., Meeberg, P.C. van de, Kouwen, M. van, Leerdam, M. van, Vangala, D.B., Vecht, J., Verhulst, M.L., Doeberitz, M.V., Weitz, J., Zachariae, S., Loeffler, M., Mecklin, J.P., Kloor, M., Vasen, H.F.

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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report von Dominguez-Valentin, M., Seppälä, T.T., Sampson, J.R., Macrae, F., Winship, I., Evans, D.G., Scott, R.J., Burn, J., Möslein, G., Bernstein, I., Pylvänäinen, K., Renkonen-Sinisalo, L., Lepistö, A., Lindblom, A., Plazzer, J.P., Tjandra, D., Thomas, H., Green, K., Lalloo, F., Crosbie, E.J., Hill, J., Capella, G., Pineda, M., Navarro, M., Vidal, J.B., Ronlund, K., Nielsen, R.T., Yilmaz, M., Elvang, L.L., Katz, L., Nielsen, M., Broeke, S.W. ten, Nakken, S., Hovig, E., Sunde, L., Kloor, M., Doeberitz, M.V., Ahadova, A., Lindor, N., Steinke-Lange, V., Holinski-Feder, E., Mecklin, J.P., Moller, P.

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Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database von Moller, P., Seppala, T.T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D.G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R.H., Jeffries, J., Vasen, H.F.A., Burn, J., Nakken, S., Hovig, E., Rodland, E.A., Tharmaratnam, K., Cappel, W.H.D.T.N., Hill, J., Wijnen, J.T., Jenkins, M.A., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Renkonen-Sinisalo, L., Valentin, M.D., Frayling, I.M., Plazzer, J.P., Pylvanainen, K., Genuardi, M., Mecklin, J.P., Moeslein, G., Sampson, J.R., Capella, G.

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Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database von Dominguez-Valentin, M., Sampson, J.R., Seppala, T.T., Broeke, S.W. ten, Plazzer, J.P., Nakken, S., Engel, C., Aretz, S., Jenkins, M.A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D.G., Burn, J., Greenblatt, M., Hovig, E., Cappel, W.H.D.T.N.C., Sijmons, R.H., Bertario, L., Tibiletti, M.G., Cavestro, G.M., Lindblom, A., Valle, A. della, Lopez-Kostner, F., Gluck, N., Katz, L.H., Heinimann, K., Vaccaro, C.A., Buttner, R., Gorgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Huneburg, R., Doeberitz, M.V., Loeffler, M., Rahner, N., Schackert, H.K., Steinke-Lange, V., Schmiegel, W., Vangala, D., Pylvanainen, K., Renkonen-Sinisalo, L., Hopper, J.L., Win, A.K., Haile, R.W., Lindor, N.M., Gallinger, S., Marchand, L. le, Newcomb, P.A., Figueiredo, J.C., Thibodeau, S.N., Wadt, K., Therkildsen, C., Okkels, H., Ketabi, Z., Moreira, L., Sanchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Blanco, I., Green, K., Lalloo, F., Crosbie, E.J., Hill, J., Denton, O.G., Frayling, I.M., Rodland, E.A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T.A., Gonzalez, M.L., Kalfayan, P., Tjandra, D., Winship, I.M., Macrae, F., Moslein, G., Mecklin, J.P., Nielsen, M., Moller, P.

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No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies von Engel, C., Vasen, H.F., Seppala, T., Aretz, S., Bigirwamungu-Bargeman, M., Boer, S.Y. de, Bucksch, K., Buttner, R., Holinski-Feder, E., Holzapfel, S., Huneburg, R., Jacobs, M.A.J.M., Jarvinen, H., Kloor, M., Doeberitz, M.V., Koornstra, J.J., Kouwen, M. van, Langers, A.M., Meeberg, P.C. van de, Morak, M., Moslein, G., Nagengast, F.M., Pylvanainen, K., Rahner, N., Renkonen-Sinisalo, L., Sanduleanu, S., Schackert, H.K., Schmiegel, W., Schulmann, K., Steinke-Lange, V., Strassburg, C.P., Vecht, J., Verhulst, M.L., Cappel, W.D.T.N., Zachariae, S., Mecklin, J.P., Loeffler, M.

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Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report von Seppala, T.T., Ahadova, A., Dominguez-Valentin, M., Macrae, F., Evans, D.G., Therkildsen, C., Sampson, J., Scott, R., Burn, J., Moslein, G., Bernstein, I., Holinski-Feder, E., Pylvanainen, K., Renkonen-Sinisalo, L., Lepisto, A., Lautrup, C.K., Lindblom, A., Plazzer, J.P., Winship, I., Tjandra, D., Katz, L.H., Aretz, S., Huneburg, R., Holzapfel, S., Heinimann, K., Valle, A. della, Neffa, F., Gluck, N., Cappel, W.H.D.T.N., Vasen, H., Morak, M., Steinke-Lange, V., Engel, C., Rahner, N., Schmiegel, W., Vangala, D., Thomas, H., Green, K., Lalloo, F., Crosbie, E.J., Hill, J., Capella, G., Pineda, M., Navarro, M., Blanco, I., Broeke, S. ten, Nielsen, M., Ljungmann, K., Nakken, S., Lindor, N., Frayling, I., Hovig, E., Sunde, L., Kloor, M., Mecklin, J.P., Kalager, M., Moller, P.

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Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report von Seppala, T., Pylvanainen, K., Evans, D.G., Jarvinen, H., Renkonen-Sinisalo, L., Bernstein, I., Holinski-Feder, E., Sala, P., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R., Jeffries, J., Vasen, H., Burn, J., Nakken, S., Hovig, E., Rodland, E.A., Tharmaratnam, K., Cappel, W.H.D.T.N., Hill, J., Wijnen, J., Jenkins, M., Genuardi, M., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Frayling, I.M., Plazzer, J.P., Sampson, J.R., Capella, G., Moslein, G., Mecklin, J.P., Moller, P.

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Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database von Moller, P., Seppala, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D.G., Lindblom, A., Macrae, F., Blanco, I., Jeffries, J., Vasen, H., Burn, J., Nakken, S., Hovig, E., Rodland, E.A., Tharmaratnam, K., Cappel, W.H.D.T.N., Hill, J., Wijnen, J., Jenkins, M., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Renkonen-Sinisalo, L., Frayling, I.M., Plazzer, J.P., Pylvanainen, K., Genuardi, M., Mecklin, J.P., Moslein, G., Sampson, J.R., Capella, G.

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