Discovering High-Affinity Ligands for Proteins: SAR by NMR von Shuker, Suzanne B., Hajduk, Philip J., Meadows, Robert P., Fesik, Stephen W.

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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR von Hajduk, P. J, Sheppard, G, Nettesheim, D. G, Olejniczak, E. T, Shuker, S. B, Meadows, R. P, Steinman, D. H, Carrera, G. M, Marcotte, P. A, Severin, J, Walter, K, Smith, H, Gubbins, E, Simmer, R, Holzman, T. F, Morgan, D. W, Davidsen, S. K, Summers, J. B, Fesik, S. W

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP von Fesik, Stephen W, Sun, Chaohong, Cai, Mengli, Gunasekera, Angelo H, Meadows, Robert P, Wang, Hong, Chen, Jun, Zhang, Haichao, Wu, Wei, Xu, Nan, Ng, Shi-Chung

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NMR structure and mutagenesis of the FADD (Mort1) death-effector domain von Fesik, Stephen W, Eberstadt, Matthias, Huang, Baohua, Chen, Zehan, Meadows, Robert P, Ng, Shi-Chung, Zheng, Lixin, Lenardo, Michael J

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc von Zhou, Ming-Ming, Ravichandran, Kodimangalam S, Olejniczak, Edward T, Petros, Andrew M, Meadows, Robert P, Sattler, Michael, Harlan, John E, Wade, Warren S, Burakoff, Steven J, Fesik, Stephen W

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain von Fesik, Stephen W, Liu, Zhihong, Sun, Chaohong, Olejniczak, Edward T, Meadows, Robert P, Betz, Stephen F, Oost, Thorsten, Herrmann, Julia, Wu, Joe C

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death von MUCHMORE, S. W, SATTLER, M, NG, S.-C, FESIK, S. W, LIANG, H, MEADOWS, R. P, HARLAN, J. E, YOON, H. S, NETTESHEIM, D, CHANG, B. S, THOMPSON, C. B, WONG, S.-L

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Solution structure of a pleckstrin-homology domain von Yoon, Ho Sup, Hajduk, Philip J, Petros, Andrew M, Olejniczak, Edward T, Meadows, Robert P, Fesik, Stephen W

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An approach for high-throughput structure determination of proteins by NMR spectroscopy von Medek, A, Olejniczak, E T, Meadows, R P, Fesik, S W

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Discovering High-Affinity Ligands for Proteins von Hajduk, Philip J., Meadows, Robert P., Fesik, Stephen W.

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Stromelysin Inhibitors Designed from Weakly Bound Fragments:  Effects of Linking and Cooperativity von Olejniczak, E. T, Hajduk, P. J, Marcotte, P. A, Nettesheim, D. G, Meadows, R. P, Edalji, R, Holzman, T. F, Fesik, Stephen W

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NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP von Sun, Chaohong, Cai, Mengli, Meadows, Robert P., Xu, Nan, Gunasekera, Angelo H., Herrmann, Julia, Wu, Joe C., Fesik, Stephen W.

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Solution Structure of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator von Hansen, Andrew P, Petros, Andrew M, Meadows, Robert P, Nettesheim, David G, Mazar, Andrew P, Olejniczak, Edward T, Xu, Robert X, Pederson, Terry M, Henkin, Jack, Fesik, Stephen W

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NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain von Huang, Baohua, Eberstadt, Matthias, Olejniczak, Edward T, Meadows, Robert P, Fesik, Stephen W

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NMR-based screening in drug discovery von Hajduk, Philip J., Meadows, Robert P., Fesik, Stephen W.

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Solution Structure of the Shc SH2 Domain Complexed with a Tyrosine-Phosphorylated Peptide from the T-Cell Receptor von Zhou, Ming-Ming, Meadows, Robert P., Logan, Timothy M., Yoon, Ho Sup, Wade, Warren S., Ravichandran, Kodimangalam S., Burakoff, Steven J., Fesik, Stephen W.

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NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio von Liu, Xiaohong, Wang, Hong, Eberstadt, Matthias, Schnuchel, Arndt, Olejniczak, Edward T, Meadows, Robert P, Schkeryantz, Jeff M, Janowick, David A, Harlan, John E, Harris, Edith A.S, Staunton, Donald E, Fesik, Stephen W

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer von Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W

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NMR structural refinement of an extrahelical adenosine tridecamer d(CGCAGAATTCGCG)2 via a hybrid relaxation matrix procedure von Nikonowicz, Edward P, Meadows, Robert P, Gorenstein, David G

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Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex von Xu, Robert X, Meadows, Robert P, Fesik, Stephen W

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