MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer von Hernandez-Hoyos, Gabriela, Sewell, Toddy, Bader, Robert, Bannink, Jeannette, Chenault, Ruth A, Daugherty, Mollie, Dasovich, Maria, Fang, Hang, Gottschalk, Rebecca, Kumer, John, Miller, Robert E, Ravikumar, Padma, Wiens, Jennifer, Algate, Paul A, Bienvenue, David, McMahan, Catherine J, Natarajan, Sateesh K, Gross, Jane A, Blankenship, John W

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Preclinical characterization of MTX-101: a novel bispecific CD8 Treg modulator that restores CD8 Treg functions to suppress pathogenic T cells in autoimmune diseases von Gardell, Jennifer L, Maurer, Meghan E, Childs, Monica M, Pham, Minh N, Meengs, Brent, Julien, Susan H, Tan, Cong, Boster, Daniel R, Quach, Phoenicia, Therriault, Jon H, Hermansky, Gleda, Patton, Daniel T, Bowser, Justin, Chen, Alex, Morgan, Nadine N, Gilbertson, Emily A, Bogatzki, Lisa, Encarnacion, Kaelen, McMahan, Catherine J, Crane, Courtney A, Swiderek, Kristine M

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The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies von Nelson, Michelle H, Fritzell, Sara, Miller, Robert, Werchau, Doreen, Van Citters, Danielle, Nilsson, Anneli, Misher, Lynda, Ljung, Lill, Bader, Robert, Deronic, Adnan, Chunyk, Allison G, Schultz, Lena, Varas, Laura A, Rose, Nadia, Håkansson, Maria, Gross, Jane, Furebring, Christina, Pavlik, Peter, Sundstedt, Anette, Veitonmäki, Niina, Ramos, Hilario J, Säll, Anna, Dahlman, Anna, Bienvenue, David, von Schantz, Laura, McMahan, Catherine J, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Ellmark, Peter

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Prostatic acid phosphatase expression in human tissues von Graddis, Thomas J, McMahan, Catherine J, Tamman, Jennifer, Page, Keith J, Trager, James B

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795 APVO603: a dual 4-1BB and OX40 bispecific approach utilizing ADAPTIRTM technology designed to deliver a conditional T cell/NK response against solid tumors von Nelson, Michelle, Lucas, Ashly, Gottschalk, Rebecca, McMahan, Catherine, Gross, Jane, Ramos, Hilario

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Abstract 4995: anti-ROR1 x anti-CD3 ADAPTIR™ molecule, ES425, redirects T-cell cytotoxicity and inhibits tumor growth in preclinical models of triple-negative breast cancer von Blankenship, John W., Misher, Lynda, Mitchell, Danielle, Zhang, Nicole, Tan, Philip, Hoyos, Gabriela H., Ravikumar, Padma, Bader, Robert, McMahan, Catherine J., Miller, Robert E., Bannink, Jeannette, Fang, Hang, Parr, Lara, Dasovich, Maria, Bienvenue, David, Aguilar, Megan, Xu, Carina, Daugherty, Mollie, Woodruff, Brian, Gross, Jane A.

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796 ALG.APV-527: a 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors von Nelson, Michelle, Sundstedt, Anette, Coaña, Yago Pico de, Lucas, Ashly, Nilsson, Anneli, Ljung, Lill, Chunyk, Allison, Schultz, Lena, McMahan, Catherine, Gross, Jane, Frizell, Sara, Ramos, Hilario, Ellmark, Peter

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851 Potent tumor-directed T cell activation and in vivo tumor inhibition induced by a 4–1BB x 5T4 ADAPTIR™ bispecific antibody von Nelson, Michelle, Miller, Robert, Nilsson, Anneli, Ljung, Lill, Chunyk, Allison, McMahan, Catherine, Bienvenue, David, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Fritzell, Sara

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633 Dual-targeting of 4–1BB and OX40 with an ADAPTIR™ bispecific antibody enhances anti-tumor responses to solid tumor von Nelson, Michelle, Miller, Robert, Blahnik-Fagan, Gabriele, Loh, Lauren, Citters, Danielle Van, Misher, Lynda, Sprague, Megan, Dasovich, Maria, Barber, Irene, Maggiora, Kathy, Gruswitz, Franz, Woodruff, Brian, Huntington, Kelsey, Guinn, Aelish, Aguilar, Megan, Daugherty, Mollie, Haglin, Elizabeth, Gross, Jane, Pavlik, Peter, McMahan, Catherine, Bienvenue, David, Hernandez-Hoyos, Gabriela

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RAG Reexpression and DNA Recombination at T Cell Receptor Loci in Peripheral CD4 + T Cells von McMahan, Catherine J, Fink, Pamela J

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Modulation of TCRβ surface expression during TCR revision von Simmons, Kalynn B., Wubeshet, Maramawit, Ames, Kristina T., McMahan, Catherine J., Hale, J. Scott, Fink, Pamela J.

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97-OR: Preclinical Characterization of MTX-101, a Novel KIRxCD8 Targeting Bispecific CD8 Treg Modulator von Patton, Daniel, Pham, Minh, Gardell, Jennifer L, Boster, Daniel, Julien, Susan, Mcmahan, Catherine, Crane, Courtney, Swiderek, Kristine M

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RAG1 Mediates Signal Sequence Recognition and Recruitment of RAG2 in V(D)J Recombination von Difilippantonio, Michael J, McMahan, Catherine J, Eastman, Quinn M, Spanopoulou, Eugenia, Schatz, David G

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T Cell Receptor Revision Does Not Solely Target Recent Thymic Emigrants von Cooper, Cristine J, Orr, Mark T, McMahan, Catherine J, Fink, Pamela J

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Pre-clinical Pharmacology and Tolerability Characterization of a Novel KIRxICOS Targeting Bispecific CD8 Treg Modulator von Pham, Thi Minh Nguyet, Bogatzki, Lisa, Boster, Dan, Bowser, Justin, Childs, Monica, Crane, Courtney, Gardell, Jennifer, Hermansky, Gleda, Julien, Susan, Meengs, Brent, Quach, Phoenicia, Tan, Cathy, Therriault, Jon, McMahan, Catherine J, Swiderek, Kristine M

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cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily von Sims, John E., March, Carl J., Cosman, David, Widmer, Michael B., MacDonald, H. Robson, McMahan, Catherine J., Grubin, Catherine E., Wignall, Janis M., Jackson, Jana L., Call, Susan M., Friend, Della, Alpert, Alan R., Gillis, Steven, Urdal, David L., Dower, Steven K.

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Su1210 A NOVEL BISPECIFIC CD8 TREG MODULATOR TARGETING CYTOLYTIC CD8 REGULATORY T CELLS REDUCES PATHOGENIC CD4 T CELLS AND INFLAMMATION IN TRANSLATIONAL MODELS OF INTESTINAL AUTOIM... von Gardell, Jennifer L., Boster, Daniel, Bowser, Justin, Crane, Courtney, Fasnacht, Rachael, Fitzpatrick, Kristin, Hermansky, Gleda, Julien, Susan, Maurer, Meghan, McMahan, Catherine J., Meengs, Brent, Patton, Daniel, Pham, Minh, Therriault, Jon, Swiderek, Kristine M.

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A KIR x CD8 targeting bispecific modulator enhances regulatory CD8 T cell functions, and reduces inflammation in models of autoimmune disease von Gardell, Jennifer L, Boster, Daniel, Bowser, Justin, Fasnacht, Rachael, Fitzpatrick, Kristin, Hermansky, Gleda, Julien, Susan, Maurer, Meghan, McMahan, Catherine, Meengs, Brent, Patton, Daniel, Pham, Minh, Therriault, Jon, Swiderek, Kristine M, Crane, Courtney

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Abstract LB172: APVO442: A bispecific T cell-engaging candidate utilizing the ADAPTIR-FLEXTMplatform technology with unique properties designed for optimal tumor distribution and c... von Gottschalk, Rebecca, Miller, Robert E., Misher, Lynda, Nelson, Michelle H., Chunyk, Allison, Woodruff, Brian, Haglin, Elizabeth, Hernandez-Hoyos, Gabriela, Pavlik, Peter, McMahan, Catherine, Ramos, Hilario J., Bienvenue, David

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Abstract LB173: APVO603: A dual 4-1BB and OX40 bispecific approach utilizing ADAPTIRTMtechnology designed to deliver a conditional T cell/NK response against solid tumors von Nelson, Michelle H., Miller, Robert E., Franke-Welch, Secil, Chenault, Ruth, Fang, Hang, Chunyk, Allison, Hernandez-Hoyos, Gabriela, Ramos, Hilario J., Bienvenue, David, McMahan, Catherine

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