Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs von Satoh, Takumi, McKercher, Scott R, Lipton, Stuart A

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Aberrant protein S -nitrosylation contributes to the pathophysiology of neurodegenerative diseases von Nakamura, Tomohiro, Prikhodko, Olga A, Pirie, Elaine, Nagar, Saumya, Akhtar, Mohd Waseem, Oh, Chang-Ki, McKercher, Scott R, Ambasudhan, Rajesh, Okamoto, Shu-ichi, Lipton, Stuart A

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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide von Qu, Jing, Nakamura, Tomohiro, Cao, Gang, Holland, Emily A, McKercher, Scott R, Lipton, Stuart A

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Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation von Akhtar, Mohd Waseem, Sanz-Blasco, Sara, Dolatabadi, Nima, Parker, James, Chon, Kevin, Lee, Michelle S., Soussou, Walid, McKercher, Scott R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Lipton, Stuart A.

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Wild-Type Microglia Extend Survival in PU.1 Knockout Mice with Familial Amyotrophic Lateral Sclerosis von Beers, David R., Henkel, Jenny S., Xiao, Qin, Zhao, Weihua, Wang, Jinghong, Yen, Albert A., Siklos, Laszlo, McKercher, Scott R., Appel, Stanley H.

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NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism von Tu, Shichun, Akhtar, Mohd Waseem, Escorihuela, Rosa Maria, Amador-Arjona, Alejandro, Swarup, Vivek, Parker, James, Zaremba, Jeffrey D., Holland, Timothy, Bansal, Neha, Holohan, Daniel R., Lopez, Kevin, Ryan, Scott D., Chan, Shing Fai, Yan, Li, Zhang, Xiaofei, Huang, Xiayu, Sultan, Abdullah, McKercher, Scott R., Ambasudhan, Rajesh, Xu, Huaxi, Wang, Yuqiang, Geschwind, Daniel H., Roberts, Amanda J., Terskikh, Alexey V., Rissman, Robert A., Masliah, Eliezer, Lipton, Stuart A., Nakanishi, Nobuki

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Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models von Lipton, Stuart A, Rezaie, Tayebeh, Nutter, Anthony, Lopez, Kevin M, Parker, James, Kosaka, Kunio, Satoh, Takumi, McKercher, Scott R, Masliah, Eliezer, Nakanishi, Nobuki

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Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells von Zhu, Saiyong, Ambasudhan, Rajesh, Sun, Woong, Kim, Hyun Jung, Talantova, Maria, Wang, Xiaojing, Zhang, Mingliang, Zhang, Yu, Laurent, Timothy, Parker, James, Kim, Han-Seop, Zaremba, Jeffrey D, Saleem, Sofiyan, Sanz-Blasco, Sara, Masliah, Eliezer, McKercher, Scott R, Cho, Yee Sook, Lipton, Stuart A, Kim, Janghwan, Ding, Sheng

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MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress von Nagar, Saumya, Noveral, Sarah M., Trudler, Dorit, Lopez, Kevin M., McKercher, Scott R., Han, Xuemei, Yates, John R., Piña-Crespo, Juan C., Nakanishi, Nobuki, Satoh, Takumi, Okamoto, Shu-ichi, Lipton, Stuart A.

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Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo von Li, Hao, Radford, Jonathan C, Ragusa, Michael J, Shea, Katherine L, McKercher, Scott R, Zaremba, Jeffrey D, Soussou, Walid, Nie, Zhiguo, Kang, Yeon-Joo, Nakanishi, Nobuki, Okamoto, Shu-ichi, Roberts, Amanda J, Schwarz, John J, Lipton, Stuart A

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S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death von Okamoto, Shu-ichi, Nakamura, Tomohiro, Cieplak, Piotr, Chan, Shing Fai, Kalashnikova, Evgenia, Liao, Lujian, Saleem, Sofiyan, Han, Xuemei, Clemente, Arjay, Nutter, Anthony, Sances, Sam, Brechtel, Christopher, Haus, Daniel, Haun, Florian, Sanz-Blasco, Sara, Huang, Xiayu, Li, Hao, Zaremba, Jeffrey D., Cui, Jiankun, Gu, Zezong, Nikzad, Rana, Harrop, Anne, McKercher, Scott R., Godzik, Adam, Yates, John R., Lipton, Stuart A.

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S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke von SHI, Zhong-Qing, SUNICO, Carmen R, MCKERCHER, Scott R, JIANKUN CUI, FENG, Gen-Sheng, NAKAMURA, Tomohiro, LIPTON, Stuart A

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Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration von Rezaie, Tayebeh, McKercher, Scott R, Kosaka, Kunio, Seki, Masaaki, Wheeler, Larry, Viswanath, Veena, Chun, Teresa, Joshi, Rabina, Valencia, Marcos, Sasaki, Shunsuke, Tozawa, Terumasa, Satoh, Takumi, Lipton, Stuart A

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NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model von Okamoto, Shu-ichi, Prikhodko, Olga, Pina-Crespo, Juan, Adame, Anthony, McKercher, Scott R., Brill, Laurence M., Nakanishi, Nobuki, Oh, Chang-ki, Nakamura, Tomohiro, Masliah, Eliezer, Lipton, Stuart A.

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Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease von Takahashi, Hiroto, Xia, Peng, Cui, Jiankun, Talantova, Maria, Bodhinathan, Karthik, Li, Wenjun, Saleem, Sofiyan, Holland, Emily A., Tong, Gary, Piña-Crespo, Juan, Zhang, Dongxian, Nakanishi, Nobuki, Larrick, James W., McKercher, Scott R., Nakamura, Tomohiro, Wang, Yuqiang, Lipton, Stuart A.

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Novel Therapeutic Approach for Excitatory Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases von Ghatak, Swagata, Talantova, Maria, McKercher, Scott R, Lipton, Stuart A

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MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model von Cho, Eun-Gyung, Zaremba, Jeffrey D, McKercher, Scott R, Talantova, Maria, Tu, Shichun, Masliah, Eliezer, Chan, Shing Fai, Nakanishi, Nobuki, Terskikh, Alexey, Lipton, Stuart A

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Dual neuroprotective pathways of a pro‐electrophilic compound via HSF‐1‐activated heat‐shock proteins and Nrf2‐activated phase 2 antioxidant response enzymes von Satoh, Takumi, Rezaie, Tayebeh, Seki, Masaaki, Sunico, Carmen R., Tabuchi, Takahito, Kitagawa, Tomomi, Yanagitai, Mika, Senzaki, Mutsumi, Kosegawa, Chihiro, Taira, Hideharu, McKercher, Scott R., Hoffman, Jennifer K., Roth, Gregory P., Lipton, Stuart A.

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Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs von Satoh, Takumi, McKercher, Scott R., Lipton, Stuart A.

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S-nitrosylation of Cdk5: Potential implications in amyloid-β-related neurotoxicity in Alzheimer disease von Qu, Jing, Nakamura, Tomohiro, Holland, Emily A., McKercher, Scott R., Lipton, Stuart A.

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