Eprenetapopt (APR-246) and Azacitidine in TP53 -Mutant Myelodysplastic Syndromes von Sallman, David A, DeZern, Amy E, Garcia-Manero, Guillermo, Steensma, David P, Roboz, Gail J, Sekeres, Mikkael A, Cluzeau, Thomas, Sweet, Kendra L, McLemore, Amy, McGraw, Kathy L, Puskas, John, Zhang, Ling, Yao, Jiqiang, Mo, Qianxing, Nardelli, Lisa, Al Ali, Najla H, Padron, Eric, Korbel, Greg, Attar, Eyal C, Kantarjian, Hagop M, Lancet, Jeffrey E, Fenaux, Pierre, List, Alan F, Komrokji, Rami S

Volltext

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype von Sallman, David A., McLemore, Amy F., Aldrich, Amy L., Komrokji, Rami S., McGraw, Kathy L., Dhawan, Abhishek, Geyer, Susan, Hou, Hsin-An, Eksioglu, Erika A., Sullivan, Amy, Warren, Sarah, MacBeth, Kyle J., Meggendorfer, Manja, Haferlach, Torsten, Boettcher, Steffen, Ebert, Benjamin L., Al Ali, Najla H., Lancet, Jeffrey E., Cleveland, John L., Padron, Eric, List, Alan F.

Volltext

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype von Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A.B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng, List, Alan F.

Volltext

Editorial: Understanding leukemia biology using genome editing techniques von Jimenez-Morales, Silvia, Banerjee, Kaushik, Saha, Nirmalya, Basu, Amrita, McGraw, Kathy L.

Volltext

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis von Jeong, Jong Jin, Gu, Xiaorong, Nie, Ji, Sundaravel, Sriram, Liu, Hui, Kuo, Wen-Liang, Bhagat, Tushar D, Pradhan, Kith, Cao, John, Nischal, Sangeeta, McGraw, Kathy L, Bhattacharyya, Sanchari, Bishop, Michael R, Artz, Andrew, Thirman, Michael J, Moliterno, Alison, Ji, Peng, Levine, Ross L, Godley, Lucy A, Steidl, Ulrich, Bieker, James J, List, Alan F, Saunthararajah, Yogen, He, Chuan, Verma, Amit, Wickrema, Amittha

Volltext

Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes von Cluzeau, Thomas, McGraw, Kathy L, Irvine, Brittany, Masala, Erico, Ades, Lionel, Basiorka, Ashley A, Maciejewski, Jaroslaw, Auberger, Patrick, Wei, Sheng, Fenaux, Pierre, Santini, Valeria, List, Alan

Volltext

TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia von Yun, Seongseok, Vincelette, Nicole D, Yu, Xiaoqing, Watson, Gregory W, Fernandez, Mario R, Yang, Chunying, Hitosugi, Taro, Cheng, Chia-Ho, Freischel, Audrey R, Zhang, Ling, Li, Weimin, Hou, Hsinan, Schaub, Franz X, Vedder, Alexis R, Cen, Ling, McGraw, Kathy L, Moon, Jungwon, Murphy, Daniel J, Ballabio, Andrea, Kaufmann, Scott H, Berglund, Anders E, Cleveland, John L

Volltext

Immunohistochemical pattern of p53 is a measure of TP53 mutation burden and adverse clinical outcome in myelodysplastic syndromes and secondary acute myeloid leukemia von McGraw, Kathy L, Nguyen, Johnny, Komrokji, Rami S, Sallman, David, Al Ali, Najla H, Padron, Eric, Lancet, Jeffrey E, Moscinski, Lynn C, List, Alan F, Zhang, Ling

Volltext

Dual pyroptotic biomarkers predict erythroid response in lower-risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin von Wang, Chen, McGraw, Kathy L, McLemore, Amy F, Komrokji, Rami, Basiorka, Ashley A, Al Ali, Najla, Lancet, Jeffrey E, Padron, Eric, Kosmider, Olivier, Fontenay, Michaela, Fenaux, Pierre, List, Alan F, Sallman, David A

Volltext

Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes von McLemore, Amy F., Hou, Hsin-An, Meyer, Benjamin S., Lam, Nghi B., Ward, Grace A., Aldrich, Amy L., Rodrigues, Matthew A., Vedder, Alexis, Zhang, Ling, Padron, Eric, Vincelette, Nicole D., Sallman, David A., Abdel-Wahab, Omar, List, Alan F., McGraw, Kathy L.

Volltext

Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors von McGraw, Kathy L, Basiorka, Ashley A, Johnson, Joseph O, Clark, Justine, Caceres, Gisela, Padron, Eric, Heaton, Ruth, Ozawa, Yukiyasu, Wei, Sheng, Sokol, Lubomir, List, Alan F

Volltext

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes von Sundaravel, Sriram, Duggan, Ryan, Bhagat, Tushar, Ebenezer, David L, Liu, Hui, Yu, Yiting, Bartenstein, Matthias, Unnikrishnan, Madhu, Karmakar, Subhradip, Liu, Ting-Chun, Torregroza, Ingrid, Quenon, Thomas, Anastasi, John, McGraw, Kathy L, Pellagatti, Andrea, Boultwood, Jacqueline, Yajnik, Vijay, Artz, Andrew, Le Beau, Michelle M, Steidl, Ulrich, List, Alan F, Evans, Todd, Verma, Amit, Wickrema, Amittha

Volltext

Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes von Ward, Grace A., McGraw, Kathy L., Abbas-Aghababazadeh, Farnoosh, Meyer, Benjamin S., McLemore, Amy F., Vincelette, Nicole D., Lam, Nghi B., Aldrich, Amy L., Al Ali, Najla H., Padron, Eric, Pinilla-Ibarz, Javier, Masala, Erico, Santini, Valeria, Kosmider, Olivier, Fontenay, Michaela, Fenaux, Pierre, Johnson, Joseph, Fridley, Brooke L., List, Alan F.

Volltext

Implications for metabolic disturbances in myelodysplastic syndromes von McGraw, Kathy L., Larson, Daniel R.

Volltext

Erythropoietin receptor signaling is membrane raft dependent von McGraw, Kathy L, Fuhler, Gwenny M, Johnson, Joseph O, Clark, Justine A, Caceres, Gisela C, Sokol, Lubomir, List, Alan F

Volltext

A Call to Arms: Overcoming challenges in Myelodysplastic Syndromes therapy advances von McGraw, Kathy L., Aplan, Peter D., Pavletic, Steven Z.

Volltext

Predicted leukocyte telomere length and risk of myeloid neoplasms von Sullivan, Shannon M, Cole, Ben, Lane, John, Meredith, John J, Langer, Erica, Hooten, Anthony J, Roesler, Michelle, McGraw, Kathy L, Pankratz, Nathan, Poynter, Jenny N

Volltext

Non-del(5q) myelodysplastic syndromes–associated loci detected by SNP-array genome-wide association meta-analysis von McGraw, Kathy L., Cheng, Chia-Ho, Chen, Y. Ann, Hou, Hsin-An, Nilsson, Björn, Genovese, Giulio, Cluzeau, Thomas, Pellagatti, Andrea, Przychodzen, Bartlomiej P., Mallo, Mar, Arenillas, Leonor, Mohamedali, Azim, Adès, Lionel, Sallman, David A., Padron, Eric, Sokol, Lubomir, Moreilhon, Chimene, Raynaud, Sophie, Tien, Hwei-Fang, Boultwood, Jacqueline, Ebert, Benjamin L., Sole, Francesc, Fenaux, Pierre, Mufti, Ghulam J., Maciejewski, Jaroslaw P., Kanetsky, Peter A., List, Alan F.

Volltext

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A von Gonzalez-Menendez, Pedro, Phadke, Ira, Olive, Meagan E., Joly, Axel, Papoin, Julien, Yan, Hongxia, Galtier, Jérémy, Platon, Jessica, Kang, Sun Woo Sophie, McGraw, Kathy L., Daumur, Marie, Pouzolles, Marie, Kondo, Taisuke, Boireau, Stéphanie, Paul, Franciane, Young, David J., Lamure, Sylvain, Mirmira, Raghavendra G., Narla, Anupama, Cartron, Guillaume, Dunbar, Cynthia E., Boyer-Clavel, Myriam, Porat-Shliom, Natalie, Dardalhon, Valérie, Zimmermann, Valérie S., Sitbon, Marc, Dever, Thomas E., Mohandas, Narla, Da Costa, Lydie, Udeshi, Namrata D., Blanc, Lionel, Kinet, Sandrina, Taylor, Naomi

Volltext

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions von Shin, Tae-Hoon, Zhou, Yifan, Chen, Shirley, Cordes, Stefan, Grice, Max Z., Fan, Xing, Lee, Byung-Chul, Aljanahi, Aisha A., Hong, So Gun, Vaughan, Kelli L., Mattison, Julie A., Kohama, Steven G., Fabre, Margarete A., Uchida, Naoya, Demirci, Selami, Corat, Marcus A. F., Métais, Jean-Yves, Calvo, Katherine R., Buscarlet, Manuel, Natanson, Hannah, McGraw, Kathy L., List, Alan F., Busque, Lambert, Tisdale, John F., Vassiliou, George S., Yu, Kyung-Rok, Dunbar, Cynthia E.

Volltext