Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes von Kaur, Simranjeet, Tam, Nok Yin, McDonough, Michael A, Schofield, Christopher J, Aik, Wei Shen

Volltext

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates von Brem, Jürgen, Cain, Ricky, Cahill, Samuel, McDonough, Michael A., Clifton, Ian J., Jiménez-Castellanos, Juan-Carlos, Avison, Matthew B., Spencer, James, Fishwick, Colin W. G., Schofield, Christopher J.

Volltext

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases von Aik, WeiShen, McDonough, Michael A, Thalhammer, Armin, Chowdhury, Rasheduzzaman, Schofield, Christopher J

Volltext

Inhibition of 2-oxoglutarate dependent oxygenases von Rose, Nathan R, McDonough, Michael A, King, Oliver N F, Kawamura, Akane, Schofield, Christopher J

Volltext

Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy von Wu, Yue, Li, Zhihong, McDonough, Michael A, Schofield, Christopher J, Zhang, Xiaojin

Volltext

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases von Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane

Volltext

In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery von Li, Zhihong, Wu, Yue, Zhen, Shuai, Su, Kaijun, Zhang, Linjian, Yang, Fulai, McDonough, Michael A., Schofield, Christopher J., Zhang, Xiaojin

Volltext

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors von Brewitz, Lennart, Tumber, Anthony, Pfeffer, Inga, McDonough, Michael A., Schofield, Christopher J.

Volltext

Structural studies on human 2-oxoglutarate dependent oxygenases von McDonough, Michael A, Loenarz, Christoph, Chowdhury, Rasheduzzaman, Clifton, Ian J, Schofield, Christopher J

Volltext

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α von Pollard, Patrick J., Loenarz, Christoph, Mole, David R., McDonough, Michael A., Gleadle, Jonathan M., Schofield, Christopher J., Ratcliffe, Peter J.

Volltext

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6 von Islam, Md. Saiful, McDonough, Michael A., Chowdhury, Rasheduzzaman, Gault, Joseph, Khan, Amjad, Pires, Elisabete, Schofield, Christopher J.

Volltext

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO) von Aik, WeiShen, Demetriades, Marina, Hamdan, Muhammad K. K, Bagg, Eleanor. A. L, Yeoh, Kar Kheng, Lejeune, Clarisse, Zhang, Zhihong, McDonough, Michael A, Schofield, Christopher J

Volltext

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy von Loenarz, Christoph, Sekirnik, Rok, Thalhammer, Armin, Ge, Wei, Spivakovsky, Ekaterina, Mackeen, Mukram M., McDonough, Michael A., Cockman, Matthew E., Kessler, Benedikt M., Ratcliffe, Peter J., Wolf, Alexander, Schofield, Christopher J.

Volltext

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides von Baker, Ysobel R., Thorpe, Cameron, Chen, Jinfeng, Poller, Laura M., Cox, Lina, Kumar, Pawan, Lim, Wooi F., Lie, Lillian, McClorey, Graham, Epple, Sven, Singleton, Daniel, McDonough, Michael A., Hardwick, Jack S., Christensen, Kirsten E., Wood, Matthew J. A., Hall, James P., El-Sagheer, Afaf H., Brown, Tom

Volltext

The enzymes of β-lactam biosynthesis von Hamed, Refaat B, Gomez-Castellanos, J. Ruben, Henry, Luc, Ducho, Christian, McDonough, Michael A, Schofield, Christopher J

Volltext

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers von Brem, Jürgen, van Berkel, Sander S, Zollman, David, Lee, Sook Y, Gileadi, Opher, McHugh, Peter J, Walsh, Timothy R, McDonough, Michael A, Schofield, Christopher J

Volltext

Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active von Brasnett, Amelia, Pfeffer, Inga, Brewitz, Lennart, Chowdhury, Rasheduzzaman, Nakashima, Yu, Tumber, Anthony, McDonough, Michael A., Schofield, Christopher J.

Volltext

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity von White, Mark D., Carbonare, Laura Dalle, Puerta, Mikel Lavilla, Iacopino, Sergio, Edwards, Martin, Dunne, Kate, Pires, Elisabete, Levy, Colin, McDonough, Michael A., Licausi, Francesco, Flashman, Emily

Volltext

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern von Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.

Volltext

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2 von Figg, Jr, William D, Fiorini, Giorgia, Chowdhury, Rasheduzzaman, Nakashima, Yu, Tumber, Anthony, McDonough, Michael A, Schofield, Christopher J

Volltext