A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Huma... von Gillard, Geoff O, Proctor, Jennifer L, Brooks, Melissa L., Lamothe, Tahirih L, Hyzy, Sharon L., Mikse, Oliver, McDonough, Sean, Palchaudhuri, Rahul, Bhat, Anjali, Sarma, Ganapathy N., Bhattarai, Prashant, Sawant, Pranoti, Pearse, Bradley R, Mcdonough, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates von Tisdale, John F., Donahue, Robert E., Uchida, Naoya, Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Krouse, Allen, Linde, Nathaniel S., Bonifacino, Aylin C., Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma von Pourmaleki, Maryam, Jones, Caitlin J, Ariyan, Charlotte E, Zeng, Zheng, Pirun, Mono, Navarrete, Daniel A, Li, Yanyun, Zhang, Mianlei, Nandakumar, Subhiksha, Campos, Carl, Nadeem, Saad, Klimstra, David S, Temple-Oberle, Claire F, Brenn, Thomas, Lipson, Evan J, Schenk, Kara M, Stein, Julie E, Taube, Janis M, White, Michael G, Traweek, Raymond, Wargo, Jennifer A, Kirkwood, John M, Gasmi, Billel, Goff, Stephanie L, Corwin, Alex D, McDonough, Elizabeth, Ginty, Fiona, Callahan, Margaret K, Schietinger, Andrea, Socci, Nicholas D, Mellinghoff, Ingo K, Hollmann, Travis J

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Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning von Palchaudhuri, Rahul, Pearse, Bradley R, Proctor, Jennifer L, Hyzy, Sharon L., Aslanian, Sharon, McDonough, Sean M, Sarma, Ganapathy, Brooks, Melissa L., Bhat, Anjali, Ladwig, Danielle, McShea, Molly A, Kallen, Nathan M, Li, Qing, Panwar, Rajiv, Dushime, Junia, Sawant, Pranoti, Adams, Hillary L, Falahee, Patrick C., Lamothe, Tahirih L, Gabros, Andrew D, Kien, Lena, Gillard, Geoff, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L, Hyzy, Sharon L., Adams, Hillary L, Brooks, Melissa L., Gabros, Andrew D, McDonough, Sean M, Kien, Lena, Aslanian, Sharon, Pearse, Bradley R, Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sarma, Ganapathy, McShea, Molly A, Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Tran... von Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Panwar, Rajiv, Sarma, Ganapathy, McShea, Molly A, Kien, Lena, Dushime, Junia, Adams, Hillary L, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Tumor MHC Class I Expression Associates with Intralesional Interleukin-2 Response in Melanoma von Pourmaleki, Maryam, Jones, Caitlin J., Ariyan, Charlotte E., Zeng, Zheng, Pirun, Mono, Navarrete, Daniel A., Li, Yanyun, Zhang, Mianlei, Nandakumar, Subhiksha, Campos, Carl, Nadeem, Saad, Klimstra, David S., Temple-Oberle, Claire F., Brenn, Thomas, Lipson, Evan J., Schenk, Kara M., Stein, Julie E., Taube, Janis M., White, Michael G., Traweek, Raymond, Wargo, Jennifer A., Kirkwood, John M., Gasmi, Billel, Goff, Stephanie L., Corwin, Alex D., McDonough, Elizabeth, Ginty, Fiona, Callahan, Margaret K., Schietinger, Andrea, Socci, Nicholas D., Mellinghoff, Ingo K., Hollmann, Travis J.

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Loci influencing blood pressure identified using a cardiovascular gene-centric array von Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y.-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Franceschini, N., Gaunt, T. R., Gho, J. M. I. H., Gieger, C., Gong, Y., Isaacs, A., Kleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Padmanabhan, S., Price, T. S., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., Van Iperen, E. P. A., Van Setten, J., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H.

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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning... von Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates von Uchida, Naoya, Tisdale, John F., Donahue, Robert E., Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Krouse, Allen E, Linde, Nathaniel, Bonifacino, Aylin, Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Mod... von Gillard, Geoffrey O., Proctor, Jennifer L., Brooks, Melissa L., Lamothe, Tahirih L., Hyzy, Sharon L., McDonough, Sean M., Clark, Nicholas, Palchaudhuri, Rahul, Bhat, Anjali, Sarma, Ganapathy N., Bhattarai, Prashant Raj, Sawant, Pranoti, Pearse, Bradley R., McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window a... von Pearse, Bradley R., Proctor, Jennifer L., McDonough, Sean M., Panwar, Rajiv, Sarma, Ganapathy N., Neale, Jason, Kien, Lena, Dushime, Junia, Latimer, Kellie, Lamothe, Tahirih L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Jain, Nidhi, Knihtila, Ryan, McDonagh, Charlotte F., Boitano, Anthony E., Davis, John C., Cooke, Michael P.

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A Single Dose of a Novel Anti-Human Short Half-Life Engineered CD45-Targeted Antibody-Drug Conjugate (ADC) Is Cytoreductive on Patient-Derived Tumors and Extends Survival Beyond St... von Proctor, Jennifer L., Gillard, Geoffrey O., Mikse, Oliver, Lanieri, Leanne, Lamothe, Tahirih L., Brooks, Melissa L., Kien, Lena, McDonough, Sean M., Bhat, Anjali, Palchaudhuri, Rahul, Bhattarai, Prashant raj, Sarma, Ganapathy N., Jain, Nidhi, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L., Hyzy, Sharon L., Adams, Hillary L., Brooks, Melissa, Gabros, Andrew D., McDonough, Sean M., Kien, Lena, Aslanian, Sharon, Pearse, Bradley R., Palchaudhuri, Rahul, Li, Qing, Sarma, Ganapathy N., Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L., Hyzy, Sharon L., Adams, Hillary L., Brooks, Melissa, Gabros, Andrew D., McDonough, Sean M., Kien, Lena, Aslanian, Sharon, Pearse, Bradley R., Palchaudhuri, Rahul, Li, Qing, Sarma, Ganapathy N., Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells von Palchaudhuri, Rahul, Pearse, Brad R., Proctor, Jennifer L., Hyzy, Sharon L., Aslanian, Sharon, Bhat, Anjali, Gillard, Geoff O, McDonough, Sean M., Sarma, Ganapathy N, Ladwig, Danielle, Li, Qing, Jain, Nidhi, Panwar, Rajiv, Sawant, Pranoti, Dushime, Junia, Falahee, Patrick C., Kien, Lena, Lamothe, Tahirih L, Gabros, Andrew D, Adams, Hillary L., McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Tumor MHC Class I Expression Associates with Interleukin-2 Response in Melanoma von Pourmaleki, Maryam, Jones, Caitlin J., Ariyan, Charlotte E., Zeng, Zheng, Mono Pirun, Navarrete, Daniel A., Yanyun Li, Mianlei Zhang, Subhiksha Nandakumar, Campos, Carl, Nadeem, Saad, Klimstra, David S., Temple-Oberle, Claire F., Brenn, Thomas, Lipson, Evan J., Schenk, Kara M., Stein, Julie E., Taube, Janis M., White, Michael G., Traweek, Raymond, Wargo, Jennifer A., Kirkwood, John M., Billel Gasmi, Goff, Stephanie L., Corwin, Alex, McDonough, Elizabeth, Ginty, Fiona, Callahan, Margaret K., Schietinger, Andrea, Socci, Nicholas D., Mellinghoff, Ingo K., Hollmann, Travis J.

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