Therapy-related myeloid neoplasms: when genetics and environment collide von McNerney, Megan E., Godley, Lucy A., Le Beau, Michelle M.

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Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms von Stoddart, Angela, Qian, Zhijian, Fernald, Anthony A, Bergerson, Rachel J, Wang, Jianghong, Karrison, Theodore, Anastasi, John, Bartom, Elizabeth T, Sarver, Aaron L, McNerney, Megan E, Largaespada, David A, Le Beau, Michelle M

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Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells von An, Ningfei, Khan, Saira, Imgruet, Molly K., Jueng, Lia, Gurbuxani, Sandeep, McNerney, Megan E.

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Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS von An, Ningfei, Khan, Saira, Imgruet, Molly K., Gurbuxani, Sandeep K., Konecki, Stephanie N., Burgess, Michael R., McNerney, Megan E.

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CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia von McNerney, Megan E., Brown, Christopher D., Wang, Xiaoyue, Bartom, Elizabeth T., Karmakar, Subhradip, Bandlamudi, Chaitanya, Yu, Shan, Ko, Jinkyung, Sandall, Barry P., Stricker, Thomas, Anastasi, John, Grossman, Robert L., Cunningham, John M., Le Beau, Michelle M., White, Kevin P.

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A new self: MHC-class-I-independent Natural-killer-cell self-tolerance von Kumar, Vinay, McNerney, Megan E

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CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex von Liu, Weihan, Kurkewich, Jeffrey L., Stoddart, Angela, Khan, Saira, Anandan, Dhivyaa, Gaubil, Alexandre N., Wolfgeher, Donald J., Jueng, Lia, Kron, Stephen J., McNerney, Megan E.

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Genomic studies controvert the existence of the CUX1 p75 isoform von Krishnan, Manisha, Senagolage, Madhavi D., Baeten, Jeremy T., Wolfgeher, Donald J., Khan, Saira, Kron, Stephen J., McNerney, Megan E.

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Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells von Ludwig, Lindsey M., Hawley, Katrina M., Banks, David B., Thomas-Toth, Anika T., Blazar, Bruce R., McNerney, Megan E., Leverson, Joel D., LaBelle, James L.

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Widespread genetic epistasis among cancer genes von Wang, Xiaoyue, Fu, Audrey Q., McNerney, Megan E., White, Kevin P.

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Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation von Xu, Jin, Haigis, Kevin M, Firestone, Ari J, McNerney, Megan E, Li, Qing, Davis, Elizabeth, Chen, Shann-Ching, Nakitandwe, Joy, Downing, James, Jacks, Tyler, Le Beau, Michelle M, Shannon, Kevin

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Real world predictors of response and 24-month survival in high-grade TP53-mutated myeloid neoplasms von Kaur, Amandeep, Rojek, Alexandra E., Symes, Emily, Nawas, Mariam T., Patel, Anand A., Patel, Jay L., Sojitra, Payal, Aqil, Barina, Sukhanova, Madina, McNerney, Megan E., Wu, Leo P., Akmatbekov, Aibek, Segal, Jeremy, Tjota, Melissa Y., Gurbuxani, Sandeep, Cheng, Jason X., Yeon, Su-Yeon, Ravisankar, Harini V., Fitzpatrick, Carrie, Lager, Angela, Drazer, Michael W., Saygin, Caner, Wanjari, Pankhuri, Katsonis, Panagiotis, Lichtarge, Olivier, Churpek, Jane E., Ghosh, Sharmila B., Patel, Ami B., Menon, Madhu P., Arber, Daniel A., Wang, Peng, Venkataraman, Girish

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Haploinsufficient Transcription Factors in Myeloid Neoplasms von Martinez, Tanner C, McNerney, Megan E

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The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters von Arthur, Robert K, An, Ningfei, Khan, Saira, McNerney, Megan E

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CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions von Baeten, Jeremy T., Liu, Weihan, Preddy, Isabelle C., Zhou, Ningxuan, McNerney, Megan E.

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EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy von Stoddart, Angela, Fernald, Anthony A., Davis, Elizabeth M., McNerney, Megan E., Le Beau, Michelle M.

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The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells von McNerney, Megan E., Le Beau, Michelle M.

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Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays von Kadri, Sabah, Long, Bradley C, Mujacic, Ibro, Zhen, Chao J, Wurst, Michelle N, Sharma, Shruti, McDonald, Nadia, Niu, Nifang, Benhamed, Sonia, Tuteja, Jigyasa, Seiwert, Tanguy, White, Kevin, McNerney, Megan E, Fitzpatrick, Carrie, Wang, Y. Lynn, Furtado, Larissa V, Segal, Jeremy P

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Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets von Heath, Allison P, Greenway, Matthew, Powell, Raymond, Spring, Jonathan, Suarez, Rafael, Hanley, David, Bandlamudi, Chai, McNerney, Megan E, White, Kevin P, Grossman, Robert L

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Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms von Imgruet, Molly K., Lutze, Julian, An, Ningfei, Hu, Bonnie, Khan, Saira, Kurkewich, Jeffrey, Martinez, Tanner C., Wolfgeher, Donald, Gurbuxani, Sandeep K., Kron, Stephen J., McNerney, Megan E.

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