The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease von McManus, Meagan J, Murphy, Michael P, Franklin, James L

Volltext

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress von Picard, Martin, McManus, Meagan J., Gray, Jason D., Nasca, Carla, Moffat, Cynthia, Kopinski, Piotr K., Seifert, Erin L., McEwen, Bruce S., Wallace, Douglas C.

Volltext

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange von Hoshino, Atsushi, Wang, Wei-jia, Wada, Shogo, McDermott-Roe, Chris, Evans, Chantell S., Gosis, Bridget, Morley, Michael P., Rathi, Komal S., Li, Jian, Li, Kristina, Yang, Steven, McManus, Meagan J., Bowman, Caitlyn, Potluri, Prasanth, Levin, Michael, Damrauer, Scott, Wallace, Douglas C., Holzbaur, Erika L. F., Arany, Zoltan

Volltext

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity von Morrow, Ryan M., Picard, Martin, Derbeneva, Olga, Leipzig, Jeremy, McManus, Meagan J., Gouspillou, Gilles, Barbat-Artigas, Sébastien, Dos Santos, Carlos, Hepple, Russell T., Murdock, Deborah G., Wallace, Douglas C.

Volltext

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle von Picard, Martin, Gentil, Benoit J, McManus, Meagan J, White, Kathryn, St Louis, Kyle, Gartside, Sarah E, Wallace, Douglas C, Turnbull, Douglass M

Volltext

Mouse mtDNA mutant model of Leber hereditary optic neuropathy von Lin, Chun Shi, Sharpley, Mark S, Fan, Weiwei, Waymire, Katrina G, Sadun, Alfredo A, Carelli, Valerio, Ross-Cisneros, Fred N, Baciu, Peter, Sung, Eric, McManus, Meagan J, Pan, Billy X, Gil, Daniel W, MacGregor, Grant R, Wallace, Douglas C

Volltext

Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders von Lin-Hendel, Erika G., McManus, Meagan J., Wallace, Douglas C., Anderson, Stewart A., Golden, Jeffrey A.

Volltext

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy von McManus, Meagan J., Picard, Martin, Chen, Hsiao-Wen, De Haas, Hans J., Potluri, Prasanth, Leipzig, Jeremy, Towheed, Atif, Angelin, Alessia, Sengupta, Partho, Morrow, Ryan M., Kauffman, Brett A., Vermulst, Marc, Narula, Jagat, Wallace, Douglas C.

Volltext

OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases von Sturm, Gabriel, Karan, Kalpita R., Monzel, Anna S., Santhanam, Balaji, Taivassalo, Tanja, Bris, Céline, Ware, Sarah A., Cross, Marissa, Towheed, Atif, Higgins-Chen, Albert, McManus, Meagan J., Cardenas, Andres, Lin, Jue, Epel, Elissa S., Rahman, Shamima, Vissing, John, Grassi, Bruno, Levine, Morgan, Horvath, Steve, Haller, Ronald G., Lenaers, Guy, Wallace, Douglas C., St-Onge, Marie-Pierre, Tavazoie, Saeed, Procaccio, Vincent, Kaufman, Brett A., Seifert, Erin L., Hirano, Michio, Picard, Martin

Volltext

An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes von Yardeni, Tal, Cristancho, Ana G., McCoy, Almedia J., Schaefer, Patrick M., McManus, Meagan J., Marsh, Eric D., Wallace, Douglas C.

Volltext

Trans-mitochondrial coordination of cristae at regulated membrane junctions von Picard, Martin, McManus, Meagan J., Csordás, György, Várnai, Péter, Dorn II, Gerald W., Williams, Dewight, Hajnóczky, György, Wallace, Douglas C.

Volltext

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition von Sharpley, Mark S, Marciniak, Christine, Eckel-Mahan, Kristin, McManus, Meagan, Crimi, Marco, Waymire, Katrina, Lin, Chun Shi, Masubuchi, Satoru, Friend, Nicole, Koike, Maya, Chalkia, Dimitra, MacGregor, Grant, Sassone-Corsi, Paolo, Wallace, Douglas C

Volltext

Positron Emission Tomography with [ 18 F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy von Gallagher, Evan, Hou, Catherine, Zhu, Yi, Hsieh, Chia-Ju, Lee, Hsiaoju, Li, Shihong, Xu, Kuiying, Henderson, Patrick, Chroneos, Rea, Sheldon, Malkah, Riley, Shaipreeah, Luk, Kelvin C, Mach, Robert H, McManus, Meagan J

Volltext

Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths von McManus, Meagan J., Murphy, Michael P., Franklin, James L.

Volltext

Mitochondrial antioxidants abate SARS-COV-2 pathology in mice von Guarnieri, Joseph W, Lie, Timothy, Albrecht, Yentli E Soto, Hewin, Peter, Jurado, Kellie A, Widjaja, Gabrielle A, Zhu, Yi, McManus, Meagan J, Kilbaugh, Todd J, Keith, Kelsey, Potluri, Prasanth, Taylor, Deanne, Angelin, Alessia, Murdock, Deborah G, Wallace, Douglas C

Volltext

Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest von Piel, Sarah, McManus, Meagan J., Heye, Kristina N., Beaulieu, Forrest, Fazelinia, Hossein, Janowska, Joanna I., MacTurk, Bryce, Starr, Jonathan, Gaudio, Hunter, Patel, Nisha, Hefti, Marco M., Smalley, Martin E., Hook, Jordan N., Kohli, Neha V., Bruton, James, Hallowell, Thomas, Delso, Nile, Roberts, Anna, Lin, Yuxi, Ehinger, Johannes K., Karlsson, Michael, Berg, Robert A., Morgan, Ryan W., Kilbaugh, Todd J.

Volltext

Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning von Piel, Sarah, Janowska, Joanna I., Ward, J. Laurenson, McManus, Meagan J., Jose, Joshua S., Starr, Jonathan, Sheldon, Malkah, Clayman, Carly L., Elmér, Eskil, Hansson, Magnus J., Jang, David H., Karlsson, Michael, Ehinger, Johannes K., Kilbaugh, Todd J.

Volltext

Dissociation of JNK Activation from Elevated Levels of Reactive Oxygen Species, Cytochrome c Release, and Cell Death in NGF-Deprived Sympathetic Neurons von McManus, Meagan J., Franklin, James L.

Volltext

Oxygen Exposure During Cardiopulmonary Resuscitation Is Associated With Cerebral Oxidative Injury in a Randomized, Blinded, Controlled, Preclinical Trial von Marquez, Alexandra M., Morgan, Ryan W., Ko, Tiffany, Landis, William P., Hefti, Marco M., Mavroudis, Constantine D., McManus, Meagan J., Karlsson, Michael, Starr, Jonathan, Roberts, Anna L., Lin, Yuxi, Nadkarni, Vinay, Licht, Daniel J., Berg, Robert A., Sutton, Robert M., Kilbaugh, Todd J.

Volltext

[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice von Hsieh, Chia-Ju, Hou, Catherine, Zhu, Yi, Lee, Ji Youn, Kohli, Neha, Gallagher, Evan, Xu, Kuiying, Lee, Hsiaoju, Li, Shihong, McManus, Meagan J., Mach, Robert H.

Volltext