Tracing the origins of relapse in acute myeloid leukaemia to stem cells von Shlush, Liran I., Mitchell, Amanda, Heisler, Lawrence, Abelson, Sagi, Ng, Stanley W. K., Trotman-Grant, Aaron, Medeiros, Jessie J. F., Rao-Bhatia, Abilasha, Jaciw-Zurakowsky, Ivana, Marke, Rene, McLeod, Jessica L., Doedens, Monica, Bader, Gary, Voisin, Veronique, Xu, ChangJiang, McPherson, John D., Hudson, Thomas J., Wang, Jean C. Y., Minden, Mark D., Dick, John E.

Volltext

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny von Notta, Faiyaz, Zandi, Sasan, Takayama, Naoya, Dobson, Stephanie, Gan, Olga I., Wilson, Gavin, Kaufmann, Kerstin B., McLeod, Jessica, Laurenti, Elisa, Dunant, Cyrille F., McPherson, John D., Stein, Lincoln D., Dror, Yigal, Dick, John E.

Volltext

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia von Shlush, Liran I., Zandi, Sasan, Mitchell, Amanda, Chen, Weihsu Claire, Brandwein, Joseph M., Gupta, Vikas, Kennedy, James A., Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., McLeod, Jessica L., Doedens, Monica, Medeiros, Jessie J. F., Marke, Rene, Kim, Hyeoung Joon, Lee, Kwon, McPherson, John D., Hudson, Thomas J., Pan-Leukemia Gene Panel Consortium, The HALT, Brown, Andrew M. K., Yousif, Fouad, Trinh, Quang M., Stein, Lincoln D., Minden, Mark D., Wang, Jean C. Y., Dick, John E.

Volltext

Sympatric speciation driving evolution of Late Ordovician brachiopod Zygospira in eastern North America von Sproat, Colin D., McLeod, Jessica S.A.

Volltext

Mapping the cellular origin and early evolution of leukemia in Down syndrome von Wagenblast, Elvin, Araujo, Joana, Gan, Olga, Cutting, Sarah K., Murison, Alex, Krivdova, Gabriela, Azkanaz, Maria, McLeod, Jessica L., Smith, Sabrina A., Gratton, Blaise A., Marhon, Sajid A., Gabra, Martino, Medeiros, Jessie J. F., Manteghi, Sanaz, Chen, Jian, Chan-Seng-Yue, Michelle, Garcia-Prat, Laura, Salmena, Leonardo, De Carvalho, Daniel D., Abelson, Sagi, Abdelhaleem, Mohamed, Chong, Karen, Roifman, Maian, Shannon, Patrick, Wang, Jean C. Y., Hitzler, Johann K., Chitayat, David, Dick, John E., Lechman, Eric R.

Volltext

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate von García-Prat, Laura, Kaufmann, Kerstin B., Schneiter, Florin, Voisin, Veronique, Murison, Alex, Chen, Jocelyn, Chan-Seng-Yue, Michelle, Gan, Olga I., McLeod, Jessica L., Smith, Sabrina A., Shoong, Michelle C., Parris, Darrien, Pan, Kristele, Zeng, Andy G.X., Krivdova, Gabriela, Gupta, Kinam, Takayanagi, Shin-Ichiro, Wagenblast, Elvin, Wang, Weijia, Lupien, Mathieu, Schroeder, Timm, Xie, Stephanie Z., Dick, John E.

Volltext

Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells von Wagenblast, Elvin, Azkanaz, Maria, Smith, Sabrina A., Shakib, Lorien, McLeod, Jessica L., Krivdova, Gabriela, Araújo, Joana, Shultz, Leonard D., Gan, Olga I., Dick, John E., Lechman, Eric R.

Volltext

Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML von Krivdova, Gabriela, Voisin, Veronique, Schoof, Erwin M., Marhon, Sajid A., Murison, Alex, McLeod, Jessica L., Gabra, Martino M., Zeng, Andy G.X., Aigner, Stefan, Yee, Brian A., Shishkin, Alexander A., Van Nostrand, Eric L., Hermans, Karin G., Trotman-Grant, Aaron C., Mbong, Nathan, Kennedy, James A., Gan, Olga I., Wagenblast, Elvin, De Carvalho, Daniel D., Salmena, Leonardo, Minden, Mark D., Bader, Gary D., Yeo, Gene W., Dick, John E., Lechman, Eric R.

Volltext

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation von Xie, Stephanie Z, Kaufmann, Kerstin B, Wang, Weijia, Chan-Seng-Yue, Michelle, Gan, Olga I, Laurenti, Elisa, Garcia-Prat, Laura, Takayanagi, Shin-Ichiro, Ng, Stanley W K, Xu, ChangJiang, Zeng, Andy G X, Jin, Liqing, McLeod, Jessica, Wagenblast, Elvin, Mitchell, Amanda, Kennedy, James A, Liu, Qiang, Boutzen, Héléna, Kleinau, Melissa, Jargstorf, Joseph, Holmes, Gareth, Zhang, Yang, Voisin, Veronique, Bader, Gary D, Wang, Jean C Y, Hannun, Yusuf A, Luberto, Chiara, Schroeder, Timm, Minden, Mark D, Dick, John E

Volltext

SIRP alpha Fc treatment targets human acute myeloid leukemia stem cells von Galkin, Oleksandr, McLeod, Jessica, Kennedy, James A., Jin, Liqing, Mbong, Nathan, Wong, Mark, Uger, Robert A., Minden, Mark D., Danska, Jayne S., Wang, Jean C. Y.

Volltext

CD200 expression marks leukemia stem cells in human AML von Ho, Jenny M., Dobson, Stephanie M., Voisin, Veronique, McLeod, Jessica, Kennedy, James A., Mitchell, Amanda, Jin, Liqing, Eppert, Kolja, Bader, Gary, Minden, Mark D., Dick, John E., Wang, Jean C.Y.

Volltext

P421: TARGETED DISRUPTION OF HUMAN FLT3 ERADICATES LEUKEMIC STEM CELLS WITHOUT HARMING HEALTHY HEMATOPOIETIC STEM CELLS von Araújo, Joana, Wagenblast, Elvin, Voisin, Veronique, Mcleod, Jessica, Gan, Olga, Jin, Liqing, Mitchell, Amanda, Gratton, Blaise, Cutting, Sarah, Arruda, Andrea, Doedens, Monica, Capo‐Chichi, Jose‐Mario, Minden, Mark, Sobrinho‐Simões, Manuel, Pinto‐Do‐Ó, Perpétua, Lechman, Eric, Dick, John

Volltext

A 17-gene stemness score for rapid determination of risk in acute leukaemia von Ng, Stanley W. K., Mitchell, Amanda, Kennedy, James A., Chen, Weihsu C., McLeod, Jessica, Ibrahimova, Narmin, Arruda, Andrea, Popescu, Andreea, Gupta, Vikas, Schimmer, Aaron D., Schuh, Andre C., Yee, Karen W., Bullinger, Lars, Herold, Tobias, Görlich, Dennis, Büchner, Thomas, Hiddemann, Wolfgang, Berdel, Wolfgang E., Wörmann, Bernhard, Cheok, Meyling, Preudhomme, Claude, Dombret, Hervé, Metzeler, Klaus, Buske, Christian, Löwenberg, Bob, Valk, Peter J. M., Zandstra, Peter W., Minden, Mark D., Dick, John E., Wang, Jean C. Y.

Volltext

3229 – MODELING CLONAL HEMATOPOIESIS AND THE PRE-LEUKEMIC STATE WITH CHR13Q DELETION IN HUMAN HEMATOPOIETIC STEM CELLS von Wong, Gordon, Skead, Kimberly, Mitchell, Amanda, McLeod, Jessica, Awadalla, Philip, Lechman, Eric, Dick, John

Volltext

3228 – FUNCTIONAL INVESTIGATION OF THE ARGONAUTE PROTEINS IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS von Wong, Gordon, Krivdova, Gabriela, Kim, Hyerin, Gan, Olga, Mcleod, Jessica, Lechman, Eric, Dick, John

Volltext

Rehabilitation Considerations for the Older Adult with Heart Failure: A Review of the Literature von McLeod, Jessica L., Van Dam, Ashley A., Heiss, Ashley K., Shoemaker, Michael J.

Volltext

Discovery of a New Human Hematopoietic Stem Cell Involved with Aging That Retains Memory of Immune Activation von Zeng, Andy G.X., Nagree, Murtaza S, Murison, Alexander, Lim, Isabel, Shah, Sayyam, Aguilar-Navarro, Alicia, Araújo, Joana, Parris, Darrien, McLeod, Jessica L, Jin, Liqing, Wagenblast, Elvin, Flores-Figueroa, Eugenia, Dick, John E., Xie, Stephanie Z

Volltext

Uncovering Distinct Metabolic Properties of Relapse and Relapse-Fated Clones in B-Cell Acute Lymphoblastic Leukemia von Smith, Sabrina A, Garcia Prat, Laura, Hosseini, Mohsen, Jin, Liqing, Mbong, Nathan, Doedens, Monica, McLeod, Jessica, Reisz, Julie A., Wilkerson, Rebecca, D'Alessandro, Angelo, Chan, Steven M., Jones, Courtney L, Dick, John E.

Volltext

Identification of Global miRNA Targetomes within Human Hematopoietic Progenitors and Acute Myeloid Leukemia Uncovers Unique Molecular Networks Centered on Mitochondria Function in... von Krivdova, Gabriela, Yee, Brian, Aigner, Stefan, Gabra, Martino, Shishkin, Alexander, Nguyen, Long, McLeod, Jessica L, Carley, Leah, Salmena, Leonardo, Shakib, Lorien, Minden, Mark D., Van Nostrand, Eric L, Yeo, Gene W., Lechman, Eric R., Dick, John E.

Volltext

Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs von Dobson, Stephanie M., Garcia-Prat, Laura, Vanner, Robert J., Wintersinger, Jeffrey, Waanders, Esme, Gu, Zhaohui, McLeod, Jessica, Gan, Olga I., Grandal, Ildiko, Payne-Turner, Debbie, Edmonson, Michael N., Ma, Xiaotu, Fan, Yiping, Voisin, Veronique, Chan-Seng-Yue, Michelle, Xie, Stephanie Z., Hosseini, Mohsen, Abelson, Sagi, Gupta, Pankaj, Rusch, Michael, Shao, Ying, Olsen, Scott R., Neale, Geoffrey, Chan, Steven M., Bader, Gary, Easton, John, Guidos, Cynthia J., Danska, Jayne S., Zhang, Jinghui, Minden, Mark D., Morris, Quaid, Mullighan, Charles G., Dick, John E.

Volltext