Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis von McLean, W H Irwin, Palmer, Colin N A, Irvine, Alan D, Terron-Kwiatkowski, Ana, Zhao, Yiwei, Liao, Haihui, Lee, Simon P, Goudie, David R, Sandilands, Aileen, Campbell, Linda E, Smith, Frances J D, O'Regan, Gráinne M, Watson, Rosemarie M, Cecil, Jo E, Bale, Sherri J, Compton, John G, DiGiovanna, John J, Fleckman, Philip, Lewis-Jones, Sue, Arseculeratne, Gehan, Sergeant, Ann, Munro, Colin S, El Houate, Brahim, McElreavey, Ken, Halkjaer, Liselotte B, Bisgaard, Hans, Mukhopadhyay, Somnath

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Keratins and skin disorders von Lane, EB, McLean, WHI

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The molecular genetic analysis of the expanding pachyonychia congenita case collection von Wilson, N.J., O'Toole, E.A., Milstone, L.M., Hansen, C.D., Shepherd, A.A., Al-Asadi, E., Schwartz, M.E., McLean, W.H.I., Sprecher, E., Smith, F.J.D.

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Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis von McAleer, M.A., Jakasa, I., Hurault, G., Sarvari, P., McLean, W.H.I., Tanaka, R.J., Kezic, S., Irvine, A.D.

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A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis von Hulshof, L., Hack, D.P., Hasnoe, Q.C.J., Dontje, B., Jakasa, I., Riethmüller, C., McLean, W.H.I., Aalderen, W.M.C., van't Land, B., Kezic, S., Sprikkelman, A.B., Middelkamp‐Hup, M.A.

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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis von Paternoster, Lavinia, Standl, Marie, Waage, Johannes, Baurecht, Hansjörg, Hotze, Melanie, Strachan, David P, Curtin, John A, Bønnelykke, Klaus, Tian, Chao, Takahashi, Atsushi, Esparza-Gordillo, Jorge, Alves, Alexessander Couto, Thyssen, Jacob P, den Dekker, Herman T, Ferreira, Manuel A, Altmaier, Elisabeth, Sleiman, Patrick Ma, Xiao, Feng Li, Gonzalez, Juan R, Marenholz, Ingo, Kalb, Birgit, Yanes, Maria Pino, Xu, Cheng-Jian, Carstensen, Lisbeth, Groen-Blokhuis, Maria M, Venturini, Cristina, Pennell, Craig E, Barton, Sheila J, Levin, Albert M, Curjuric, Ivan, Bustamante, Mariona, Kreiner-Møller, Eskil, Lockett, Gabrielle A, Bacelis, Jonas, Bunyavanich, Supinda, Myers, Rachel A, Matanovic, Anja, Kumar, Ashish, Tung, Joyce Y, Hirota, Tomomitsu, Kubo, Michiaki, McArdle, Wendy L, Henderson, A J, Kemp, John P, Zheng, Jie, Smith, George Davey, Rüschendorf, Franz, Bauerfeind, Anja, Lee-Kirsch, Min Ae, Arnold, Andreas, Homuth, Georg, Schmidt, Carsten O, Mangold, Elisabeth, Cichon, Sven, Keil, Thomas, Rodríguez, Elke, Peters, Annette, Franke, Andre, Lieb, Wolfgang, Novak, Natalija, Fölster-Holst, Regina, Horikoshi, Momoko, Pekkanen, Juha, Sebert, Sylvain, Husemoen, Lise L, Grarup, Niels, de Jongste, Johan C, Rivadeneira, Fernando, Hofman, Albert, Jaddoe, Vincent Wv, Pasmans, Suzanne Gma, Elbert, Niels J, Uitterlinden, André G, Marks, Guy B, Thompson, Philip J, Matheson, Melanie C, Robertson, Colin F, Ried, Janina S, Li, Jin, Zuo, Xian Bo, Zheng, Xiao Dong, Yin, Xian Yong, Sun, Liang Dan, McAleer, Maeve A, O'Regan, Grainne M, Fahy, Caoimhe Mr, Campbell, Linda E, Macek, Milan, Kurek, Michael, Hu, Donglei, Eng, Celeste, Postma, Dirkje S, Feenstra, Bjarke, Geller, Frank, Hottenga, Jouke Jan, Middeldorp, Christel M, Hysi, Pirro, Bataille, Veronique, Spector, Tim, Tiesler, Carla Mt

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Early‐life regional and temporal variation in filaggrin‐derived natural moisturizing factor, filaggrin‐processing enzyme activity, corneocyte phenotypes and plasmin activity: impli... von McAleer, M.A., Jakasa, I., Raj, N., O'Donnell, C.P.F., Lane, M.E., Rawlings, A.V., Voegeli, R., McLean, W.H.I., Kezic, S., Irvine, A.D.

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A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 von Strange, Amy, Capon, Francesca, Spencer, Chris C A, Knight, Jo, Weale, Michael E, Allen, Michael H, Barton, Anne, Band, Gavin, Bellenguez, Céline, Bergboer, Judith G M, Blackwell, Jenefer M, Bramon, Elvira, Bumpstead, Suzannah J, Casas, Juan P, Cork, Michael J, Corvin, Aiden, Deloukas, Panos, Dilthey, Alexander, Duncanson, Audrey, Edkins, Sarah, Estivill, Xavier, Fitzgerald, Oliver, Freeman, Colin, Giardina, Emiliano, Gray, Emma, Hofer, Angelika, Hüffmeier, Ulrike, Hunt, Sarah E, Irvine, Alan D, Jankowski, Janusz, Kirby, Brian, Langford, Cordelia, Lascorz, Jesús, Leman, Joyce, Leslie, Stephen, Mallbris, Lotus, Markus, Hugh S, Mathew, Christopher G, McLean, W H Irwin, McManus, Ross, Mössner, Rotraut, Moutsianas, Loukas, Naluai, Asa T, Nestle, Frank O, Novelli, Giuseppe, Onoufriadis, Alexandros, Palmer, Colin N A, Perricone, Carlo, Pirinen, Matti, Plomin, Robert, Potter, Simon C, Pujol, Ramon M, Rautanen, Anna, Riveira-Munoz, Eva, Ryan, Anthony W, Salmhofer, Wolfgang, Samuelsson, Lena, Sawcer, Stephen J, Schalkwijk, Joost, Smith, Catherine H, Ståhle, Mona, Su, Zhan, Tazi-Ahnini, Rachid, Traupe, Heiko, Viswanathan, Ananth C, Warren, Richard B, Weger, Wolfgang, Wolk, Katarina, Wood, Nicholas, Worthington, Jane, Young, Helen S, Zeeuwen, Patrick L J M, Hayday, Adrian, Burden, A David, Griffiths, Christopher E M, Kere, Juha, Reis, André, McVean, Gilean, Evans, David M, Brown, Matthew A, Barker, Jonathan N, Peltonen, Leena, Donnelly, Peter, Trembath, Richard C

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A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis von Weidinger, Stephan, Willis-Owen, Saffron A G, Kamatani, Yoichiro, Baurecht, Hansjörg, Morar, Nilesh, Liang, Liming, Edser, Pauline, Street, Teresa, Rodriguez, Elke, O'Regan, Grainne M, Beattie, Paula, Fölster-Holst, Regina, Franke, Andre, Novak, Natalija, Fahy, Caoimhe M, Winge, Mårten C G, Kabesch, Michael, Illig, Thomas, Heath, Simon, Söderhäll, Cilla, Melén, Erik, Pershagen, Göran, Kere, Juha, Bradley, Maria, Lieden, Agne, Nordenskjold, Magnus, Harper, John I, McLean, W H Irwin, Brown, Sara J, Cookson, William O C, Lathrop, G Mark, Irvine, Alan D, Moffatt, Miriam F

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Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene–environment interaction von Jabbar‐Lopez, Z.K., Craven, J., Logan, K., Greenblatt, D., Marrs, T., Radulovic, S., McLean, W.H.I., Lack, G., Strachan, D.P., Perkin, M.R., Peacock, J.L., Flohr, C.

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The Phenotypic and Molecular Genetic Features of Pachyonychia Congenita von McLean, W.H. Irwin, Hansen, C. David, Eliason, Mark J., Smith, Frances J.D.

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Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis von Visser, M.J., Landeck, L., Campbell, L.E., McLean, W.H.I., Weidinger, S., Calkoen, F., John, S.M., Kezic, S.

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Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris von McLean, W H Irwin, Smith, Frances J D, Irvine, Alan D, Terron-Kwiatkowski, Ana, Sandilands, Aileen, Campbell, Linda E, Zhao, Yiwei, Liao, Haihui, Evans, Alan T, Goudie, David R, Lewis-Jones, Sue, Arseculeratne, Gehan, Munro, Colin S, Sergeant, Ann, O'Regan, Gráinne, Bale, Sherri J, Compton, John G, DiGiovanna, John J, Presland, Richard B, Fleckman, Philip

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The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases von Szeverenyi, Ildiko, Cassidy, Andrew J., Chung, Cheuk Wang, Lee, Bernett T.K., Common, John E.A., Ogg, Stephen C., Chen, Huijia, Sim, Shu Yin, Goh, Walter L.P., Ng, Kee Woei, Simpson, John A., Chee, Li Lian, Eng, Goi Hui, Li, Bin, Lunny, Declan P., Chuon, Danny, Venkatesh, Aparna, Khoo, Kian Hoe, McLean, W.H. Irwin, Lim, Yun Ping, Lane, E. Birgitte

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Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis von Winge, M.C.G., Bilcha, K.D., Liedén, A., Shibeshi, D., Sandilands, A., Wahlgren, C.-F., McLean, W.H.I., Nordenskjöld, M., Bradley, M.

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Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations von Chen, H., Common, J.E.A., Haines, R.L., Balakrishnan, A., Brown, S.J., Goh, C.S.M., Cordell, H.J., Sandilands, A., Campbell, L.E., Kroboth, K., Irvine, A.D., Goh, D.L.M., Tang, M.B.Y., van Bever, H.P., Giam, Y.C., McLean, W.H.I., Lane, E.B.

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Statins Downregulate K6a Promoter Activity: A Possible Therapeutic Avenue for Pachyonychia Congenita von Zhao, Yiwei, Gartner, Ulrike, Smith, Frances J.D., McLean, W.H. Irwin

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Stratum corneum and systemic biomarkers in infantile AD von McAleer, M.A., Jakasa, I., Hurault, G., Sarvari, P., McLean, W.H.I., Tanaka, R.J., Kezic, S., Irvine, A.D.

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Systemic and stratum corneum biomarkers of severity in infant AD include markers of innate and Th-related immunity and angiogenesis von McAleer, MA, Jakasa, I, Hurault, G, Sarvari, P, McLean, WHI, Tanaka, RJ, Kezic, S, Irvine, AD

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Mutations in POGLUT1 in Galli–Galli/Dowling–Degos disease von Wilson, N.J., Cole, C., Kroboth, K., Hunter, W.N., Mann, J.A., McLean, W.H.I., Kernland Lang, K., Beltraminelli, H., Sabroe, R.A., Tiffin, N., Sobey, G.J., Borradori, L., Simpson, E., Smith, F.J.D.

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