The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time von Ertl, Peter, Altmann, Eva, McKenna, Jeffrey M

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Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications von Henning, Nathaniel J, Manford, Andrew G, Spradlin, Jessica N, Brittain, Scott M, Zhang, Erika, McKenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Rape, Michael, Nomura, Daniel K

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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation von Spradlin, Jessica N., Hu, Xirui, Ward, Carl C., Brittain, Scott M., Jones, Michael D., Ou, Lisha, To, Milton, Proudfoot, Andrew, Ornelas, Elizabeth, Woldegiorgis, Mikias, Olzmann, James A., Bussiere, Dirksen E., Thomas, Jason R., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications von Ward, Carl C, Kleinman, Jordan I, Brittain, Scott M, Lee, Patrick S, Chung, Clive Yik Sham, Kim, Kenneth, Petri, Yana, Thomas, Jason R, Tallarico, John A, McKenna, Jeffrey M, Schirle, Markus, Nomura, Daniel K

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Bardoxolone conjugation enables targeted protein degradation of BRD4 von Tong, Bingqi, Luo, Mai, Xie, Yi, Spradlin, Jessica N., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC von Boike, Lydia, Cioffi, Alexander G., Majewski, Felix C., Co, Jennifer, Henning, Nathaniel J., Jones, Michael D., Liu, Gang, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB von King, Elizabeth A., Cho, Yoojin, Hsu, Nathan S., Dovala, Dustin, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Deubiquitinase-targeting chimeras for targeted protein stabilization von Henning, Nathaniel J., Boike, Lydia, Spradlin, Jessica N., Ward, Carl C., Liu, Gang, Zhang, Erika, Belcher, Bridget P., Brittain, Scott M., Hesse, Matthew J., Dovala, Dustin, McGregor, Lynn M., Valdez Misiolek, Rachel, Plasschaert, Lindsey W., Rowlands, David J., Wang, Feng, Frank, Andreas O., Fuller, Daniel, Estes, Abigail R., Randal, Katelyn L., Panidapu, Anoohya, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Chiral Diaryliodonium Phosphate Enables Light Driven Diastereoselective α‑C(sp3)–H Acetalization von Ye, Baihua, Zhao, Jie, Zhao, Ke, McKenna, Jeffrey M, Toste, F. Dean

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Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes von Talbot, Eric P. A, Fernandes, Talita de A, McKenna, Jeffrey M, Toste, F. Dean

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Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function von Luo, Mai, Spradlin, Jessica N., Boike, Lydia, Tong, Bingqi, Brittain, Scott M., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Manumycin polyketides act as molecular glues between UBR7 and P53 von Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn M., Brittain, Scott M., Jones, Michael D., Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Development, Synthesis, and in silico Investigations of Novel Acyclic Allyl Fluoride Derivatives von Chauhan, Nishita, Singh, Harjinder, Singh, Kamal Nain, McKenna, Jeffrey M., Saini, Vaneet

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The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes von Thornbury, Richard T, Saini, Vaneet, Fernandes, Talita de A, Santiago, Celine B, Talbot, Eric P A, Sigman, Matthew S, McKenna, Jeffrey M, Toste, F Dean

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A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL von Tong, Bingqi, Spradlin, Jessica N, Novaes, Luiz F. T, Zhang, Erika, Hu, Xirui, Moeller, Malte, Brittain, Scott M, McGregor, Lynn M, McKenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Maimone, Thomas J, Nomura, Daniel K

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Targeted Protein Degradation through E2 Recruitment von Forte, Nafsika, Dovala, Dustin, Hesse, Matthew J., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Gold-Catalyzed Redox Synthesis of Imidazo[1,2-a]pyridines using Pyridine N-Oxide and Alkynes von Talbot, Eric P. A., Richardson, Melodie, McKenna, Jeffrey M., Toste, F. Dean

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Oxidative cyclization reagents reveal tryptophan cation–π interactions von Xie, Xiao, Moon, Patrick J., Crossley, Steven W. M., Bischoff, Amanda J., He, Dan, Li, Gen, Dao, Nam, Gonzalez-Valero, Angel, Reeves, Audrey G., McKenna, Jeffrey M., Elledge, Susanna K., Wells, James A., Toste, F. Dean, Chang, Christopher J.

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An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Ki... von Gonzalez-Valero, Angel, Reeves, Audrey G., Page, Annika C. S., Moon, Patrick J., Miller, Edward, Coulonval, Katia, Crossley, Steven W. M., Xie, Xiao, He, Dan, Musacchio, Patricia Z., Christian, Alec H., McKenna, Jeffrey M., Lewis, Richard A., Fang, Eric, Dovala, Dustin, Lu, Yipin, McGregor, Lynn M., Schirle, Markus, Tallarico, John A., Roger, Pierre P., Toste, F. Dean, Chang, Christopher J.

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Amine Protection/α-Activation with the tert-Butoxythiocarbonyl Group: Application to Azetidine Lithiation–Electrophilic Substitution von Hodgson, David M, Mortimer, Claire L, McKenna, Jeffrey M

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